6 results match your criteria: "St Josef Hospital of the Ruhr-University Bochum[Affiliation]"
Risk factors for non-benefit of implantable cardioverter defibrillator therapy.
Sci Rep
January 2025
Department of Cardiology and Rhythmology, St. Josef-Hospital of the Ruhr University Bochum, Gudrunstraße 56, 44791, Bochum, Germany.
Studies have demonstrated overall prognostic benefits of ICD implantation in patients at increased risk of sudden cardiac death. However, results are inconsistent in certain subgroups. This study aims to evaluate the prognostic implications of comorbidities on ICD outcomes and compare trends in patient selection and outcomes over a decade-long inclusion period.
View Article and Find Full Text PDFElevated Troponins after COVID-19 Hospitalization and Long-Term COVID-19 Symptoms: Incidence, Prognosis, and Clinical Outcomes-Results from a Multi-Center International Prospective Registry (HOPE-2).
J Clin Med
April 2024
Cardiology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Article Synopsis
- * Researchers analyzed data from the HOPE-2 registry, examining 2382 patients discharged alive and tracking their mortality and long-term COVID-19 symptoms.
- * Findings reveal that patients with elevated troponin levels face higher mortality rates and are more likely to experience lasting cardiovascular issues, such as fatigue and dyspnea, after discharge.
Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2.
Curr Opin Microbiol
April 2024
Institute of Physiology, Department of Cellular and Translational Physiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital of the Ruhr University Bochum, Bochum, Germany; HCEMM-SU Cardiovascular Comorbidities Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Hungary; Department of Physiology, Cardiovascular Research Institute Maastricht University Maastricht, Maastricht, the Netherlands. Electronic address:
Until now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention.
View Article and Find Full Text PDFAdvancements in targeted therapies for generalized acetylcholine receptor antibody positive myasthenia gravis: Beginnings of a paradigm shift.
Eur J Neurol
December 2023
Department of Neurology, St Josef Hospital of the Ruhr-University Bochum, Bochum, Germany.
Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.
Front Endocrinol (Lausanne)
January 2019
Larry L. Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, United States.
Previously, we identified chromograninA positive hormone-negative (CPHN) cells in high frequency in human fetal and neonatal pancreas, likely representing nascent endocrine precursor cells. Here, we characterize the putative endocrine fate and replicative status of these newly formed cells. To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.
View Article and Find Full Text PDFβ-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation.
J Clin Endocrinol Metab
February 2016
Larry L. Hillblom Islet Research Center (A.E.B., S.D., J.H., M.C., K.Z., P.C.B.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-7073; Institute of Pathology (H.F.), Division of Clinical and Functional Anatomy, Medical University of Innsbruck, A-6020 Innsbruck, Austria; St Josef Hospital of the Ruhr-University Bochum (J.J.M.), 44791 Bochum, Germany; and Division of Endocrinology, Diabetes, Metabolism, and Nutrition (R.A.R.), Mayo Clinic College of Medicine, Rochester, Minnesota 55905.
Context: Type 2 diabetes is characterized by a β-cell deficit and a progressive defect in β-cell function. It has been proposed that the deficit in β-cells may be due to β-cell degranulation and transdifferentiation to other endocrine cell types.
Objective: The objective of the study was to establish the potential impact of β-cell dedifferentiation and transdifferentiation on β-cell deficit in type 2 diabetes and to consider the alternative that cells with an incomplete identity may be newly forming rather than dedifferentiated.