75 results match your criteria: "St Johns Medical College and Hospital[Affiliation]"

Article Synopsis
  • Cancer is predicted to rise significantly, with 35 million new cases expected by 2050, mainly impacting low- and middle-income countries, particularly in the SAARC region.
  • There is a research investment and output gap in SAARC countries compared to high-income nations, leaving a lack of local studies and clinical trials in crucial areas like targeted therapy and immunotherapy.
  • Addressing the challenges of healthcare access, cultural and economic barriers, and limited funding in SAARC countries requires collaboration, improved research infrastructure, and local studies to develop practical and affordable cancer treatments.
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  • - The South Asian region faces a critical shortage of oncology professionals due to inadequate education and training programs, impacting the quality of cancer care.
  • - Challenges for oncology workers include lack of trained personnel, poor healthcare infrastructure, and limited educational resources.
  • - The paper suggests both short-term strategies to enhance training and long-term goals to create self-sufficient cancer care systems through regional collaboration and innovative education.
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Article Synopsis
  • Cancer care in SAARC countries faces major challenges like poor infrastructure, lack of skilled professionals, and economic issues, leading to delayed diagnoses and worse health outcomes.
  • There are significant disparities in healthcare systems across the region, with some countries providing free public services while others rely heavily on out-of-pocket payments, creating financial inequities for cancer patients.
  • To improve cancer care, coordinated efforts are needed, including better infrastructure, expanded health insurance, and national cancer control programs, along with regional collaboration to ensure equitable access and advance health goals.
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Article Synopsis
  • * In 2022, cancer accounted for about 9.3% of global cases and 12% of deaths in this region, with major cancers including lung, head and neck, gastrointestinal, cervical, and breast cancers.
  • * The text emphasizes the need for regional collaboration to create an effective cancer control plan, stressing the importance of strong political commitment to tackle the growing cancer crisis and align with Sustainable Development Goals for 2030.
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Background: Cyberbullying can be a traumatic experience for adolescents. It can affect their psychosocial functioning, development, and mental well-being in the long term. Though mental health support is needed to help adolescents, parents, and schools, they do not seek appropriate support.

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Unusual Airway Foreign Bodies in Children: Demographics and Management.

J Indian Assoc Pediatr Surg

August 2024

Department of Pediatric Surgery, St. Johns Medical College and Hospital, Bengaluru, Karnataka, India.

Article Synopsis
  • The study aimed to analyze the demographics and management of unusual airway foreign bodies (UAFBs) in children over a 20-year period.
  • Out of 531 children who underwent bronchoscopic removal, 74 had UAFBs like pen caps, whistles, and glass bangles, with most cases involving children under 5 and presenting symptoms like cough and respiratory distress.
  • The findings indicated that UAFBs in children are relatively common, primarily affecting boys, with the left bronchus being the most frequent site of impaction and bronchoscopic retrieval showing a favorable outcome despite some challenges.
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Background: The 3-year training in the critical care medicine (CCM) specialty is a relatively new recognized program in India. This program has been run at a few premier institutes across India over the past few years.

Objective: The present study aimed to get a critical appraisal of the 3-year training program in CCM from the initial 50 trained Indian intensivists, regarding their research, publications, and self-perceived clinical training adequacy in the various areas of the CCM.

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Pancreatic cancer is an aggressive malignancy. Recurrences are very high despite high-quality surgery necessitating adjuvant therapy. The evolution of adjuvant therapy took several decades and gradually evolved from single-agent chemotherapy to multi-agent chemotherapy.

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Objective: To evaluate the effectiveness of methylene blue dye in detecting sentinel lymph nodes (SLNs) in women with early-stage operable (defined as FIGO I-IIA) cervical cancer. It also aims to evaluate procedural challenges and accuracy.

Method: This prospective study, which focused on 20 women with early-stage cervical cancer, was carried out between June 2016 and December 2017.

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Background: Arthroscopic knee procedures are one amongst the common surgical interventions for problems in the knee. It is technically more demanding than an open procedure and is associated with several potential complications. During arthroscopy procedures, several technical challenges may arise, and even experienced surgeons may encounter new issues.

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Article Synopsis
  • - A study was conducted in India to investigate the impact of SARS-CoV-2 infection on patients with autoimmune rheumatic diseases (AIRD) who are taking immunosuppressive medications, comparing them to healthy controls living in the same households.
  • - The research included 889 participants, with 379 having AIRD and 510 without, finding that 36% of patients with AIRD tested positive for anti-SARS-CoV-2 antibodies compared to 38% of controls, with slight variations among different cities.
  • - Notably, in Kolkata, patients with AIRD had significantly lower levels of antibodies compared to controls, particularly among those with connective tissue diseases compared to those with inflammatory arthritis, indicating that certain groups may be more
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We present updated, evidence-based clinical practice guidelines from the Indian Society of Pediatric Nephrology (ISPN) for the management of urinary tract infection (UTI) and primary vesicoureteric reflux (VUR) in children. These guidelines conform to international standards; Institute of Medicine and AGREE checklists were used to ensure transparency, rigor, and thoroughness in the guideline development. In view of the robust methodology, these guidelines are applicable globally for the management of UTI and VUR.

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Background: Stroke related to cerebral venous thrombosis (CVT) is uncommon, with untoward lethal outcomes. Systemic anticoagulation is the treatment of choice. However, some patients can be resistant to this treatment.

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Objectives: To study in children with septic shock: 1) variation in peripheral perfusion index (PI), which is a derived variable from pulse oximetry; 2) correlation between PI and lactate concentration; and 3) exploratory diagnostic evaluation between mortality and PI.

Design: Prospective observational study (from October 2018 to March 2020).

Setting: Pediatric emergency department and PICU of a tertiary hospital in India.

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Tuberculosis (TB) is a deadly infection that can lead to disseminated disease in children <15years of age exhibiting risk factors such as low host immunity, concurrent infection(s), and/or malnutrition. A case involving a 14-year-old boy diagnosed with disseminated tuberculosis is reported. On investigation, the patient was positive for coronavirus disease 2019 (COVID-19) antibodies, GeneXpert (Cepheid, Sunnyvale, CA) positive for TB with multisystem involvement, lymphopenia, and highly elevated inflammatory markers, indicating multisystem inflammatory syndrome in children (MIS-C) and disseminated TB.

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Clinical features and outcomes of patients with diacylglycerol kinase epsilon nephropathy: a nationwide experience.

Pediatr Nephrol

September 2023

Department of Pediatrics, Division of Nephrology, ICMR Center for Advanced Research in Nephrology, All India Institute of Medical Sciences, New Delhi, 110029, India.

Background: Thrombotic microangiopathy (TMA) is usually caused due to dysregulation of the alternative complement pathway. Rarely, thrombotic microangiopathy is caused by non-complement mediated mutations in diacylglycerol kinase epsilon (DGKE); information about therapy and outcome of these patients is limited.

Methods: Medical records of patients, younger than 18 years, diagnosed with TMA and variants in DGKE were reviewed to include 12 patients from seven centers.

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With proliferation in research on high-risk psychosis spectrum diseases, it is crucial to distinguish a prodrome or psychosis-like episode in children and adolescents from true psychosis. The limited role of psychopharmacology in such circumstances is well-documented, underlining the difficulties in diagnosing treatment resistance. To add to the confusion is emerging data on the head-to-head comparison trials for treatment-resistant and treatment-refractory schizophrenia.

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Objectives: To evaluate use of sustained low efficiency dialysis (SLED) in critically ill children with acute kidney injury in a resource-limited setting.

Design: Observational database cohort study (December 2016 to January 2020).

Setting: PICU of a tertiary hospital in India.

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Background: Work-related musculoskeletal disorder (WMSD) is a collective and descriptive term used for the symptoms caused or aggravated by work. Significant WMSDs can affect the productivity and Quality of Life (QOL) of nurses. This study was undertaken to estimate the prevalence of WMSDs, identify their risk factors, and find the association, if any.

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Importance: High blood pressure (BP) in children and adolescents is becoming one of the most common health conditions worldwide and is much more widely prevalent than previously thought.

Objective: To estimate the prevalence of high BP in adolescents in India and identify associated factors.

Design, Setting, And Participants: This cross-sectional study is a secondary analysis of data from the Comprehensive National Nutrition Survey (CNNS, 2016-2018), which used a multistage, stratified, probability proportion to size cluster sampling design to enroll a nationally representative sample of households and individuals aged 10 to 19 years across all states and union territories of India.

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Subclinical Kwashiorkor in Adults: A New Age Paradigm.

Indian J Endocrinol Metab

August 2022

Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.

Childhood protein-energy undernutrition (PEU) is a well-recognized problem and therefore a lot of work has been done to identify and manage paediatric PEU. Though there have been several reports of low protein consumption in adults from developing countries, PEU and its subtle forms (subclinical PEU) are not yet recognized as adult disorders. Physicians and public perception do not favour easy recognition and action.

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Background And Aims: Painful diabetic peripheral neuropathy (PDPN) is a common complication of type 2 diabetes. The unrelenting pain associated with PDPN adversely affects a patient's quality of life. Recognizing the crucial role that sleep plays in the metabolic control of diabetes, this study aims to estimate the prevalence of sleep impairment in painful diabetic peripheral neuropathy (PDPN) and identify the factors associated with it.

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Fetal heart rate (FHR) is an important parameter for assessing fetal well-being and is usually measured by doppler ultrasound. Fetal phonocardiography can provide non-invasive, easy-to-use and passive alternative for fetal monitoring method if reliable FHR measurements can be made even in noisy clinical environments. Therefore, this work presents an automatic algorithm to determine FHR from the fetal heart sound recordings in a noisy clinical environment.

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Intraosseous mucoepidermoid carcinoma (MEC) is a rare neoplasm, generally presenting in the posterior mandible and occurring in the 3rd-5th decade. This condition may mimic ameloblastoma both clinically and radiologically, with challenges in diagnosis. We present the case of a 51-year-old female who presented with a history of swelling over her jaw for one month.

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