2 results match your criteria: "St Elizabeth Oncological Institute[Affiliation]"
Photodynamic effect of hypericin after topical application in the ex ovo quail chorioallantoic membrane model.
Planta Med
January 2014
Dept. of Biophysics, Faculty of Sciences, P. J. Šafárik University, Košice, Slovakia.
Photosensitizing properties of hypericin are well known, and the chicken chorioallantoic membrane has previously been used to test photodynamic effects of hypericin and other substances. In our study the photodynamic effect of hypericin in the ex ovo quail chorioallantoic membrane model was evaluated. Steady-state and time-resolved fluorescence spectroscopy of hypericin solution in PEG-400 and its mixture in PBS was performed to assess and characterize the process of aggregation and disaggregation of hypericin during the drug formulation preparation.
View Article and Find Full Text PDFLymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2.
Blood
April 2006
Department of Internal Medicine, St Elizabeth Oncological Institute, Bratislava, Slovakia.
Article Synopsis
- There is increasing interest in immunotherapy for lymphoma and how certain proteins, like PI-9 and bcl-2, might affect treatment responses.
- In this study, researchers analyzed how the expression of PI-9, which inactivates granzyme B, and bcl-2, which inhibits cell death, influenced lymphoma's sensitivity to T cells and NK cells.
- Results showed that while both PI-9 and bcl-2 were present in many lymphoma samples, these factors didn't affect the lymphoma cells' susceptibility to cytotoxic T and NK cells, suggesting that traditional immune escape mechanisms may not hinder the effectiveness of immunotherapy.