5 results match your criteria: "St Andrew's Center for Burns and Plastic Surgery[Affiliation]"
Episomal Induced Pluripotent Stem Cells: Functional and Potential Therapeutic Applications.
Cell Transplant
December 2019
St Andrew's Center for Burns and Plastic Surgery, Chelmsford, United Kingdom.
The term episomal induced pluripotent stem cells (EiPSCs) refers to somatic cells that are reprogrammed into induced pluripotent stem cells (iPSCs) using non-integrative episomal vector methods. This reprogramming process has a better safety profile compared with integrative methods using viruses. There is a current trend toward using episomal plasmid reprogramming to generate iPSCs because of the improved safety profile.
View Article and Find Full Text PDFTopical Application of Human Wharton's Jelly Mesenchymal Stem Cells Accelerates Mouse Sciatic Nerve Recovery and is Associated with Upregulated Neurotrophic Factor Expression.
Cell Transplant
December 2019
Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Peripheral nerve regeneration following injury is often slow and impaired, which results in weakened and denervated muscle with subsequent atrophy. Human Wharton's jelly mesenchymal stem cells (hWJ-MSC) have potential regenerative properties which, however, remain unknown in mouse nerve recovery. This study investigated the effect of the topical application of hWJ-MSC onto repairing transected sciatic nerves in a mouse model.
View Article and Find Full Text PDFA New Face Subunit Transplant Model in Mice, Containing Skin, Mandible, and Oral Mucosa for Future Face Vascularized Composite Allotransplantation Studies.
Plast Reconstr Surg
July 2019
From the Department of Plastic and Reconstructive Surgery, the Center for Vascularized Composite Allotransplantation, the Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University and Medical College; St Andrew's Center for Burns and Plastic Surgery; and the Department of Plastic Surgery, IPS Universitaria/León XIII Hospital, University of Antioquia.
Background: In immunologic research, mice have advantages over other animals, such as low costs, easy handling, suitable life cycle, and adequate laboratory resources. However, vascularized composite allotransplantation surgery using mice is not popular, partly because of technical difficulties and high mortality rates. The authors' goal was to demonstrate a face transplantation model in mice that includes skin, mandible, and oral mucosa.
View Article and Find Full Text PDFCharacterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice.
Data Brief
August 2018
Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Article Synopsis
- The article introduces new characterization data on naive C57BL/6 transgenic mice that overexpress a protein called Blimp-1 specifically in T cells using the pLCK promoter.
- It focuses on various aspects like the phenotype of these mice, the levels of Blimp-1 overexpression, and how this affects T cell development and proliferation.
- For more insights on the role of Blimp-1 in T cell responses related to skin allotransplantation, readers are directed to a related study by Wang et al. (2018).
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1.
Mol Immunol
July 2018
Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Plastic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Background: B lymphocyte-induced maturation protein 1 (Blimp-1) transcription factor is expressed in multiple cell lineages and in particular, T cells. However, the role of Blimp-1 in T cell-mediated allograft tolerance is still unknown.
Methods: This study is the first to investigate transplanted skin allograft survival using transgenic (Tg) mice with T cell overexpression of Blimp-1.