111 results match your criteria: "Sri Siddhartha Medical College[Affiliation]"

Non-ossifying fibroma (NOF) is a benign expansive lytic lesion more frequently found in children and adolescents at the metaphysis of long bones in and around the knee joint, typically resolving spontaneously or by ossification. This report presents a rare case of an 11-year-old child with a pathological subtrochanteric femur fracture attributed to an underlying NOF. We describe the diagnosis and surgical management of curettage and internal fixation using a proximal humerus locking plate, resulting in complete resorption of the lytic zone and an excellent clinical outcome.

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Actinomycosis is an uncommon infection of the middle ear.Actinomycosis of ear can mimic other common diagnosis of middle ear. The treatment of actinomycosis of the middle ear differs from that of otitis media caused by aerobic bacteria, therefore an accurate diagnosis is necessary.

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Background: Breast cancer is the most common cancer among females, worldwide. Cancer screening in developing countries is mainly opportunistic type, characterized by low coverage and over-screening of women with increased access to health care services. This study was thus designed to understand the various factors preventing the participation and utilization of breast cancer screening, thereby study the different approaches for encouraging their participation and also the effectiveness of different ways of communication to Anganwadi Workers (AWW) and Anganwadi Helpers (AWH) in increasing breast cancer screening uptake at cancer screening camps.

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Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease.

Scand J Immunol

December 2024

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, Washington, USA.

Article Synopsis
  • Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is rising in incidence, especially in countries like India, where it has become the second highest in the world.* -
  • The disease is linked to an inappropriate immune response involving various helper T cell subsets and their cytokines, which contribute to gut inflammation and severity.* -
  • The review discusses how different T cell types, including CD8, NKT, and γδT cells, affect IBD outcomes and also explores potential therapeutic options for managing the disease.*
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HEART Score: Prospective Evaluation of Its Accuracy and Applicability.

Indian J Crit Care Med

August 2024

Department of Emergency Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

Background: The History, Electrocardiogram, Age, Risk factors, and Troponin I (HEART) score is a simple method to risk stratify patients with chest pain according to the risk for incidence of major adverse cardiac events (MACEs).

Materials And Methods: A 202-patient prospective, single center study at Sri Siddhartha Medical College, Tumkur. Patients included were those who were presented to the emergency department (ED) due to non-traumatic chest pain, irrespective of age or any previous medical treatments, and were later referred to the cardiac care unit (CCU), cardiology department (CD).

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Background Schoolbags or backpacks have been an essential part of the education system for a long time. However, a hefty backpack causes the child to arch the back excessively or bend their head and trunk forward to withstand the weight of the schoolbag. If the student carries the backpack on one shoulder, he/she bends to the opposite side to compensate for the extra weight, which may damage the shoulders and spine.

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Article Synopsis
  • - This study evaluates how effective intravenous diltiazem and metoprolol are for controlling heart rates in atrial fibrillation patients with fast ventricular rates, while also examining potential side effects like low blood pressure and slow heart rate.
  • - Following a thorough review of 19 relevant studies, the analysis found that diltiazem was 39% more effective than metoprolol at achieving a heart rate of less than 110 beats per minute.
  • - Despite the differences in rate control effectiveness, both medications showed no significant variations in the incidence of bradycardia (slow heart rate) or hypotension (low blood pressure), suggesting similar safety profiles.
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Background: Contraceptive information and services are fundamental to the health and human rights of all individuals. Low contraceptive use is a major challenge faced in India. To determine whether a lack of awareness of contraceptive methods was a factor, we assessed the perception of women on contraceptive methods, their safety and efficacy and further determined whether their demographic background played any role in their perception.

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Advances in cardiology have led to improved survival among patients with congenital heart disease (CHD). Racial disparities in cardiovascular and maternal outcomes are well known and are likely to be more profound among pregnant women with CHD. Using the 2001 to 2018 National Inpatient Sample, we identified all hospitalizations for delivery among women ≥ 18 years of age with CHD.

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Background: Inflammatory bowel disease (IBD) and dependent cannabis use or cannabis use disorder (CUD+) are independent risk factors for cardiovascular diseases. Usage of cannabis for pain increased in IBD patients. However, associated cardiovascular safety remains unclear.

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Background: The treatment of Kummell disease remains controversial, with a wide variety of options proposed in the literature. This study aims to introduce a unique and minimally invasive approach for the treatment of Kummell disease and present the clinical results of this technique.

Methods: Twenty patients underwent surgery using the minimally invasive surgery transpedicular intrabody cage (MISTIC) technique from 2014 to 2016.

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The global pandemic period from 2020 to 2022 caused important alterations in oncology care. This study aimed to describe the trends and variations in patient characteristics, comorbidities, and treatment approaches during this time in Romania. We conducted a retrospective database search to identify patients with rectal cancer who underwent surgical intervention between 2020 and 2022 and the year 2019, which served as a pre-pandemic period control.

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Anal fistulas often cause significant impairment to patients' health-related quality of life (HRQOL). This cross-sectional study aimed to compare the HRQOL between patients with anal fistulas with inflammatory bowel disease (IBD) and those without, hypothesizing significant differences in HRQOL scores between these groups. The secondary objectives were to identify specific aspects of life quality most affected and explore potential variables influencing HRQOL.

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Background: Postoperative analgesia is of utmost importance in the treatment of patients undergoing surgery. Good postoperative pain management reduces hospital stay and improves early ambulation. This study compared the efficacy of epidural bupivacaine with buprenorphine to butorphanol in lower limb orthopedic surgery.

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Introduction: Continued tobacco use in cancer patients leads to decreased treatment efficacy and safety, decreased survival, decreased quality of life, and an increased risk of cancer recurrence and primary tumours at other sites.

Objective: To determine the prevalence of continued tobacco usage during the first 6 months of diagnosis among tobacco-related head and neck cancer patients seeking care from a tertiary care centre and the factors associated with it.

Methods: A facility-based cohort study was conducted at a tertiary care centre in Puducherry, India.

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The shortage of organs for transplantation is a global crisis, with an increasing demand and an inadequate supply of organ donors. The convergence of biology and engineering has led to the emergence of 3D bioprinting, which enables the precise and customizable construction of biological structures. Various 3D bioprinting techniques include inkjet printing, extrusion printing, and laser-assisted bioprinting (LAB).

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Article Synopsis
  • * Patients with fungal infections exhibited higher rates of obesity, significant comorbidities, and increased use of ventilators and ICU admissions, along with markedly higher mortality rates compared to those without fungal infections.
  • * The second, fourth, and fifth waves of the pandemic were linked to greater mortality risks, particularly related to certain drug-resistant fungal species, highlighting the complex interplay between COVID-19 severity and secondary fungal infections.
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Preeclampsia is a leading cause of maternal and fetal morbidity and mortality worldwide. The role of vitamin D supplementation during early pregnancy in the prevention of preeclampsia remains unclear. Our objective was to synthesize and critically appraise the available evidence from observational and interventional studies to determine the effects of early pregnancy vitamin D supplementation on the risk of preeclampsia.

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Importance: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs).

Objective: To study the efficacy of topical esmolol for healing of uninfected DFUs.

Design, Setting, And Participants: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India.

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We report a case of Histoplasma-associated hemophagocytic syndrome in a diabetes mellitus patient. The patient presented with a fever, cough, and an ulcer on the tongue. The biopsy confirmed the diagnosis of histoplasmosis from the tongue ulcer.

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Trichoderma-Mediated ZnO Nanoparticles and Their Antibiofilm and Antibacterial Activities.

J Fungi (Basel)

January 2023

Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.

Article Synopsis
  • * A study isolated a specific microorganism from soil to synthesize zinc oxide nanoparticles (ZnO NPs), which were tested against human pathogens.
  • * The results showed that ZnO NPs effectively inhibited bacterial growth and prevented biofilm formation, suggesting their potential use in treating drug-resistant infections.
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Background: Aspiration pneumonitis remains a dreaded complication that may lead to almost 9% of anaesthesia-related deaths. The presence of gastric contents has always been a contributing factor to an increased risk of aspiration. Preoperative gastric ultrasound has been suggested as a modality for determining residual volume in special populations and conditions.

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Background Musculoskeletal disorders (MSDs) are one of the most common occupational diseases. MSDs cause an economic burden as they lead to disability, absenteeism, and reduced productivity. Although many risk factors have been associated with the incidence of MSDs, little is known about the predictive factors for the length of MSD-related absenteeism.

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