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Effect of solid lipid nanoparticles loaded with valproate and metformin on pentylenetetrazole-induced epilepsy in rats.
Naunyn Schmiedebergs Arch Pharmacol
March 2025
Department of Pharmacology, Sri Shanmugha College of Pharmacy (Affiliated to the Tamil Nadu Dr.M.G.R. Medical University), Salem, 637304, Tamil Nadu, India.
Valproate is a first-line therapy for epilepsy. It enhances GABA-mediated inhibition by increasing GABA synthetase enzyme activity. However, it causes hepatotoxicity.
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