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Objectives: To evaluate the effectiveness of the chimeric Free Anterolateral Thigh (FALT) and vastus lateralis muscle (VLM) flap for reconstructing extensive defects in advanced oral squamous cell carcinoma (OSCC), particularly those involving the infratemporal fossa (ITF) and masticator space.

Methods: A retrospective study was conducted at Sri Shankara Cancer Hospital, Bangalore, from January 2023 to June 2024. It included 22 patients with T4a and T4b OSCC who underwent curative ablative surgery, ITF clearance, and reconstruction using the chimeric FALT-VLM flap.

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