3-Hydroxybenzoic acid inhibits the virulence attributes and disrupts biofilm production in clinical isolates of Acinetobacter baumannii.

Purpose: Acinetobacter baumannii (A. baumannii) is an emerging global public health threat owing to its ability to form biofilms. Here, we evaluated 3-hydroxybenzoic acid (3-HBA), a promising organic compound, for its ability to disrupt biofilm formation and virulence attributes in clinical isolates of A.

Biofilm-Associated Agr and Sar Quorum Sensing Systems of Are Inhibited by 3-Hydroxybenzoic Acid Derived from .

Biofilm-producing () is less sensitive to conventional antibiotics than free-living planktonic cells. Here, we evaluated the antibiofilm activity of () and one of its constituent compounds 3-hydroxybenzoic acid (3-HBA) against multi-drug-resistant . We performed gas chromatography-mass spectroscopy (GC-MS) to identify the major constituents in the methanolic extract of .

Molecular Docking Analysis of Siddha Formulation Parangipattai Chooranam Against Vaginal Candidiasis.

Vulvovaginal candidiasis called by its name Vellai Noi as per Siddha terminology is considerably the second most common cause of vaginal inflammation in the women of middle-aged group. Candida albicans are prioritised top among other pathogens in mediating vaginal inflammation and its related symptoms. Candida albicans exerts its virulence by secreting the enzyme known as secreted aspartyl proteinases (SAP) which allows hassle-free adherence and growth of the opportunistic pathogen.

A nickel hydroxide platform prepared on a hydroxyl-enriched screen-printed carbon electrode for oxidative electrocatalysis.

We report here the preparation of an activation-free Ni electrode (, eventually the formation of NiOOH) through enrichment of hydroxyl functional groups a base-catalyzed hydrolysis reaction on a "preanodized" screen printed carbon electrode. The as-prepared Ni electrode exhibits good electroanalytic performance for the flow injection analysis of glucose.

Acute and sub acute toxicity study on Sangu parpam.

Peptic ulcer is described in the siddha system of medicinal classification of 4448 diseases. Information on the use of Sangu Parpam in treating peptic ulcer is known. Therefore, it is of interest to document the acute and sub acute toxicity analysis on Sangu parpam in this regard.

Immune stimulatory and anti-HIV-1 potential of extracts derived from marine brown algae Padina tetrastromatica.

Background Marine brown algae are biologically diverse and their medicinal value has been explored limited. We assessed whether Padina tetrastromatica Hauck will possess the immune stimulatory and human immunodeficiency virus (HIV-1) inhibitory activity. Materials and Methods Aqueous and methanolic extracts were tested for the Th1/Th2 cytokines using PBMC.