Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics.

Pancreatic cancer is a highly fatal malignancy due to poor early detection rate and resistance to conventional therapies. This review examines the potential for liquid biopsy as a transformative technology to identify diagnostic and therapeutic targets in pancreatic cancer. Specifically, we explore emerging biomarkers such as exosomal non-coding RNAs (ncRNAs), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs).

Speech Perception and Language Abilities Among Children Using Cochlear Implants: Findings From a Primary School Age Cohort in South India.

Objectives: This study aimed to profile the speech perception and language abilities of a cohort of pediatric cochlear implant (CI) users in primary school years. It also aimed to understand the intercorrelations among audiological, child, and environmental characteristics, speech perception, and language skills and to explore the predictors of speech perception and language skills.

Design: A cross-sectional design was used for the study.

Potentials of cytokinesis blocked micronucleus assay in radiation triage and biological dosimetry.

The measurement of micronucleus (MN) in the cytokinesis-block arrested binucleated cells has been extensively used as a biomarker in many radiation biology applications in specific biodosimetry. Following radiation casualties, medical management of exposed individuals begins with triage and biological dosimetry. The cytokinesis blocked micronucleus (CBMN) assay is the alternate for the gold standard dicentric chromosome assay in radiation dose assessment.

Qualitative study on the influence of mealtime screen exposure on children's feeding practices: perspectives from paediatricians and speech-language pathologists in Chennai, Tamil Nadu.

Objective: This qualitative research study investigates perspectives on the influence of mealtime screen exposure (MTSE) on feeding practices in children through semi-structured interviews with paediatricians and speech-language pathologists (SLPs).

Design: This study used a constructivist paradigm and a qualitative research approach, employing thematic analysis, to understand the research objectives from the lens of practitioners. The researchers used transcripts from semistructured interviews to generate themes.

Refining patient care: Evaluating prescription practices of medical residents and interns in a teaching hospital through an audit.

Objective: Hospitals in India use the National Accreditation Board for Hospitals and Healthcare Providers guidelines as criteria to ensure safe prescribing practices. This audit was conducted to provide insight into in-patient prescription of drugs to (1) evaluate the quality of prescriptions (2) reduce prescription and medication errors (3) improve the quality of care in terms of prescriptions that the hospital provides to the patient.

Methods: The cross-sectional study was conducted in an in-patient department of a tertiary care teaching hospital in Chennai where 153 paper-based prescriptions were continuously collected from the internal medicine department over 1 month.

Effect of an oral stimulation protocol on breastfeeding among preterm infants: a randomised controlled trial.

Objectives: The objectives are to assess the effectiveness of a modified and adapted oral sensorimotor intervention (MA-OSMI) protocol for infants in India on the rate and performance of breastfeeding among preterm (PT) infants at discharge.

Design: Single-centre randomised control trial.

Setting: Level III B neonatal intensive care unit in a quaternary care hospital in South India.

Early Hearing Detection and Intervention programmes for neonates, infants and children in non-Asian low-income and middle-income countries: a systematic review.

Introduction: Early Hearing Detection and Intervention (EHDI) programmes were established to reduce the impact of hearing loss on children. High-income countries (HICs) have resources and knowledge to execute these programmes. However, financial and other resource constraints limit the availability of these programmes to low-income and middle-income countries (LMICs).

Shugoshin 1 expression in various cancers: a potential target for therapy.

Shugoshin 1 (SGO1) is one of the Shugoshin (guardian spirit) family proteins, which is reported to be majorly involved in the protection of centromeres and proper segregation of chromosomes during cell division. Recent studies found that the altered expression of SGO1 is associated with various cancers and genetic disorders, and suggested as a target for therapy. In the present study, we have reviewed the available literature on SGO1 gene and protein expression in various cancer-cell lines, animal models and cancer patients, and targeting SGO1 with siRNA/shRNA.

Impact of Curcumin on the IL-17A-Mediated p53-Fibrinolytic System: Mouse Proteomics and Integrated Human Fibrosis scRNAseq Insights.

Acute lung injury (ALI) is primarily driven by an intense inflammation in the alveolar epithelium. Key to this is the pro-inflammatory cytokine, Interleukin 17 (IL-17), which influences pulmonary immunity and modifies p53 function. The direct role of IL-17A in p53-fibrinolytic system is still unclear, it is important to evaluate this mechanism to regulate the ALI progression to idiopathic pulmonary fibrosis (IPF).

Comparative evaluation of pediatric endodontic rotary file systems to bending and torsion tests: A finite element analysis.

Background And Objective: The introduction of Paediatric NiTi instruments has transformed the field of paediatric endodontics. However, no studies are available on the mechanical behaviour of these files, wherein Finite Element Analysis (FEA) was found to play a major role. The objective of this study is to evaluate the mechanical behavior of three commercially available pediatric endodontic rotary file systems to bending and torsion stress analysis test through Finite Element Analysis (FEA).

Identifying Needs and Preparing for Curriculum Changes in Indian Dental Education.

Unlabelled: The aims of dental professional courses are to prepare dental healthcare providers to manage common dental diseases, perform surgeries, and offer prevention. They should also be equipped to understand the needs of the society they are serving and willing to amend their skills. As they are expected to be a part of a team providing health care, they should have the requisite leadership and managerial skills for leading the team to serve its objectives in the best possible way.

Gastro protective natural polymer aided triple drug therapy to eradicate Helicobacter pylori.

The core intent of the existing effort was to explore a triple therapy to eradicate Helicobacter pylori. A hard gelatin capsule filled with metronidazole (MNZ) floating microspheres aided with Plantago ovata seed mucilage (POSM) and Clarithromycin (CMN) floating microspheres aided with Abelmoschus esculentus fruit mucilage (AEFM). These mucilages were adopted as they have gastro-protective actions.

Assessment of overall caries risk and mode of birth delivery in infants and children with and without ECC: a cross-sectional study.

Purpose:  The study assessed the caries risk in infants and children with and without early childhood caries (ECC) using American Academy of Pediatric Dentistry Caries Risk Assessment Tool (AAPD CRAT) and identified the association between caries risk and mode of birth delivery.

Methods:  This cross-sectional study included 96 infants and children with all maxillary and mandibular primary anterior teeth and at least two primary molars erupted clinically in the oral cavity. The details on the mode of birth delivery were noted in a preformed template along with the demographic details, followed by caries risk assessment (CRA) to assess the caries risk of an individual.

Enhanced γ-H2AX Foci Frequency and Altered Gene Expression in Participants Exposed to Ionizing Radiation During I-131 Nuclear Medicine Procedures.

Purpose: Ionizing radiation-based technologies are extensively used in the diagnosis and treatment of diseases. While utilizing the technologies, exposure to a certain amount of radiation is unavoidable. Data can be obtained from participants who received radiation during medical imaging and therapeutic purposes to predict the effects of low-dose radiation.

Item Hierarchy of Vocal Fatigue Index (VFI) in School Teachers-A Study from South India.

Aim: The study aimed to identify the item hierarchy of the Vocal Fatigue Index (VFI) in school teachers using Mokken Scaling Analysis (MSA).

Method: A total of 362 school teachers from five zones in Chennai city, southern part of India, participated in the study. All subjects completed a subject-information form that had details such as age, sex, duration of vocal demand per day, number of classes taken, grades taught, and years of experience and VFI.

Data-driven drug treatment: enhancing clinical decision-making with SalpPSO-optimized GraphSAGE.

Safe drug recommendation systems play a crucial role in minimizing adverse drug reactions and enhancing patient safety. In this research, we propose an innovative approach to develop a safety drug recommendation system by integrating the Salp Swarm Optimization-based Particle Swarm Optimization (SalpPSO) with the GraphSAGE algorithm. The goal is to optimize the hyper parameters of GraphSAGE, enabling more accurate drug-drug interaction prediction and personalized drug recommendations.

Adhesive arachnoiditis: a rare cause of postoperative urinary retention.

Postoperative urinary retention is a common consequence of pelvic surgeries. It is often related both to the nature of surgery and the medication used in the perioperative period. Adhesive arachnoiditis (AA) is a rare condition, which has various clinical presentations ranging from back pain to disabling neurological deficits.

Development of a conceptual framework to understand the stakeholder's perspectives on needs and readiness of rural tele-practice for childhood communication disorders.

Background: Tele-practice promotes universal and equitable access to quality health services and emerged as an alternative to overcome physical barriers to intervention access in the 90s. There has been a steady increase in adoption since then, and during the COVID-19 pandemic, there was a surge in online modes of healthcare service delivery. Yet, tele-practice adoption and utilization in rural and remote areas are not spontaneous.

Herbal Mouthrinses for Prevention of Dental Caries in Children and Adolescents: A Systematic Review.

Unlabelled: The primary aim of this study was to evaluate the effectiveness of herbal mouthrinses (HMR) on caries prevention in children and adolescents. In addition, this systematic review assessed its effectiveness in remineralization of white spot lesions, reduction of halitosis, and improving gingival and periodontal health in orthodontic patients and patients with special healthcare needs (SHCN). A comprehensive bibliographic search was conducted in PubMed, Cochrane Central, EMBASE, AMED, ProQuest, CINAHL, AYUSH, Digital Helpline for Ayurveda Research Articles (DHARA), and Clinical Trial Gov databases.

Impact of Implementing Psychological Ownership in Undergraduate Dental Clinical Training: A Retrospective Study.

Purpose: The idea of psychological ownership (PO) has been utilized in a variety of contexts, but the significance and lessons learned from using PO in dental clinical education have not been investigated. A detailed long-term study of PO in dental clinical education will allow us to understand the effectiveness of this practice. The purpose of this paper is to compare undergraduate (UG) student's clinical performance before and after the PO system was implemented.