2 results match your criteria: "Sri Krishna College of Engineering & Technology[Affiliation]"
Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8 T Cells in Head and Neck Cancer.
Cancer Res
November 2018
Biodesign Center for Personalized Diagnostics, Arizona State University, Tempe, Arizona.
Article Synopsis
- HPV16 is linked to an increase in head and neck cancers, prompting research into T-cell immune therapies targeting these HPV-related cancers.
- The study identified 16 strong and 29 moderately immunogenic CD8 T-cell epitopes from HPV16 proteins, noting a significant increase in E2-specific T-cell reactivity in HPV-infected patients compared to healthy individuals.
- Findings suggested that T-cell dysfunction in HPV HNSCC is associated with high levels of immune suppressive markers like IDO-1, and combining PD-1 blockade with IDO-1 inhibition improved T-cell responses, highlighting a potential strategy for enhanced immunotherapy against HPV-related head and neck cancers.
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes.
Proc Natl Acad Sci U S A
April 2015
Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen and tumor antigens remains challenged by inefficient identification of immunogenic epitopes. CD8(+) T cells must distinguish immunogenic epitopes from nonimmunogenic self peptides to respond effectively against an antigen without endangering the viability of the host. Because this discrimination is fundamental to our understanding of immune recognition and critical for rational vaccine design, we interrogated the biochemical properties of 9,888 MHC class I peptides.
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