Anthropometric Indices as a Predictive Screening Tool for Hypertension among Young Indian Adults.

Background: High blood pressure (BP) is increasing at an alarming rate in India and is the leading cause of cardiovascular disease. Increasing obesity is one of the risk factors for the increasing trend in hypertension among young adults.

Objectives: This study aimed to assess the comparative abilities of anthropometric indices of general and central obesity in predicting hypertension among apparently healthy young adults.

Helicobacter pylori biofilm interference by N-acyl homoserine lactonases: in vitro and in silico approaches.

Background: Qurom quenching enzyme have an impact on treatment efficacy and prevent the recurrence of Helicobacter pylori biofilm-related infections, although it has not been thoroughly investigated in vitro and in silico. The current study aims to characterize the N-acyl homoserine lactonase, the quorum quenching AiiA protein of Bacillus licheniformis against H. pylori biofilm.

Biofilm mediated integrin activation and directing acceleration of colorectal cancer.

Bacterial biofilm plays a vital role in influencing several diseases, infections, metabolic pathways and communication channels. Biofilm influence over colorectal cancer (CRC) has been a booming area of research interest. The virulence factors of bacterial pathogen have a high tendency to induce metabolic pathway to accelerate CRC.

Rapid characterization of carbapenem-resistant Enterobacterales by multiplex lateral flow assay and detection of ceftazidime-avibactam-aztreonam synergy.

Purpose: The choice of antibiotics for treatment of Carbapenem-Resistant Enterobacterales (CRE) is increasing becoming limited due to co-expression of Metallo-beta-lactamases (MBL) along with other carbapenemases in these isolates. The study aimed to investigate the occurrence of CRE and to determine the in-vitro synergy and clinical outcomes of Ceftazidime-Avibactam and Aztreonam combination in CRE infections in adult Intensive Care Units (ICUs).

Methods: 79 CRE isolates recovered from adult ICUs during January to March 2023 were tested by O.

Current research status of anti-cancer peptides: Mechanism of action, production, and clinical applications.

The escalating rate of cancer cases, together with treatment deficiencies and long-term side effects of currently used cancer drugs, has made this disease a global burden of the 21st century. The number of breast and lung cancer patients has sharply increased worldwide in the last few years. Presently, surgical treatment, radiotherapy, chemotherapy, and immunotherapy strategies are used to cure cancer, which cause severe side effects, toxicities, and drug resistance.

Pharmacoinformatic approach to identify potential phytochemicals against SARS-CoV-2 spike receptor-binding domain in native and variants of concern.

Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) pathogenesis is initiated by the binding of SARS-CoV-2 spike (S) protein with the angiotensin-converting enzyme 2 receptor (ACE2R) on the host cell surface. The receptor-binding domain (RBD) of the S protein mediates the binding and is more prone to mutations resulting in the generation of different variants. Recently, molecules with the potential to inhibit the interaction of S protein with ACE2R have been of interest due to their therapeutic value.

Challenges Faced by Primary Caretakers of Adolescent Girls with Intellectual Disability during their Menstrual Cycle in Puducherry: A Mixed Method Study.

Background: Adolescents with Intellectually Disability (ID) compared to their normal peers face greater challenges at menarche due to their caregiver dependence for their day-to-day personal care activities.

Objective: The objective of the study was to know the sociodemographic characteristics of adolescent girls with ID and to explore the challenges faced by their primary caretakers during their menstrual cycle in Puducherry.

Subjects And Methods: The study was conducted among primary caretaker of adolescent girls with ID from December 2018 to May 2019.