Intracardiac extension of intravenous leiomyomatosis in a patient with vascular pelvic tumor and prior hysterectomy: A case report.

Uterine leiomyoma (UL) is the most common benign smooth muscle tumour of the premenopausal women. Rarely it shows malignant behaviour by metastasizing through the pelvic veins into systemic veins, inferior vena cava (IVC), there it is termed as intravenous leiomyomatosis (IVL). IVL may restrict itself within the IVC or it may extend into right heart chambers reaching up to pulmonary arteries.

Differential expression of transcription factors NF-κB and STAT3 in periodontal ligament fibroblasts and gingiva of healthy and diseased individuals.

Objective: Pathogens and host mediators can activate transcription factors in periodontal cells to bring about gene level alterations, thereby accentuating the periodontal disease process. Nuclear factor-kappa B (NF-κB) and signal transducers and activators of transcription 3 (STAT3) are two pivotal transcription factors implicated in chronic inflammatory diseases. But their importance in periodontal pathogenesis has not been investigated in detail.

An ex vivo evaluation of the efficacy of andrographolide in modulating differential expression of transcription factors and target genes in periodontal cells and its potential role in treating periodontal diseases.

Ethanopharmacological Relevance: Andrographolide is a herbal extract traditionally used in South Asian countries for treating inflammatory diseases.

Aim Of The Study: To evaluate the efficacy of andrographolide in management of periodontal disease which is a highly prevalent oral disease.

Materials And Methods: Periodontal ligament fibroblasts (PDLF) were cultured from healthy and diseased periodontium using explant culture methods.