1,465 results match your criteria: "Squamous Papilloma of the Urinary Bladder"
Prolonged detection of BPV2 in urine and blood of papillomatosis-affected cattle not grazing bracken fern.
Vet Res Commun
December 2024
Federal University of Pernambuco - UFPE, Av. Professor Moraes Rego, 1235 -Cidade Universitária, Recife, 50670-901, Brazil.
Article Synopsis
The Feasibility and Diagnostic Adequacy of PD-L1 Expression Analysis Using the Cytoinclusion Technique in Bladder Cancer: A Prospective Single-Center Study.
J Clin Med
July 2024
Department of Urology, Veneto Institute of Oncology (IOV)-IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, Italy.
Article Synopsis
- - The study investigates the role of PD-L1 expression as a potential biomarker for bladder cancer by analyzing its presence in urine samples from patients undergoing surgical treatment for the disease.
- - Among 29 patients, PD-L1 expression rates varied significantly across tumor grades, with higher detection in high-grade tumors and good agreement between urine tests (cytoinclusion) and traditional tissue analysis (histopathology).
- - The research suggests cytoinclusion can serve as a promising, non-invasive method for assessing PD-L1 levels, potentially aiding in the diagnosis and prognosis of bladder cancer, and recommends further standardization for clinical use.
Bladder papilloma: A rare benign tumor - Case report and literature review.
Int J Surg Case Rep
July 2024
Department of Urology, Mohamed VI University Hospital, Oujda, Morocco.
Article Synopsis
- * A case study involved a 66-year-old male experiencing hematuria, diagnosed with bladder papilloma after imaging and cystoscopy revealed an echogenic lesion, which was confirmed to be benign post-surgery.
- * Understanding bladder papilloma's symptoms, diagnosis, and management strategies is crucial, especially since it typically appears in younger patients and presents a low risk for recurrence or progression to aggressive cancer.
Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography.
BMC Urol
March 2024
Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 1# Banshan East Road, Hangzhou, 310022, China.
Article Synopsis
- The study examines the effectiveness of CT urography (CTU) indicators in distinguishing between bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB).
- A total of 103 patients' CTU data were analyzed for qualitative and quantitative indicators, leading to the development of a predictive model that helps in diagnosis.
- Key indicators such as junction smoothness, maximum tumor diameter, tumor-wall interface, and arterial reinforcement rate were found to significantly differentiate BUC from IPB, resulting in a high diagnostic accuracy of the combined model (AUC = 0.934).
Robot-assisted radical nephroureterectomy for upper urinary tract tumor: initial experience with the use of novel surgical robot system, hinotori.
Transl Cancer Res
December 2023
Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Article Synopsis
- The study explores the initial use of the hinotori surgical robot for robot-assisted radical nephroureterectomy (RANU) in eight patients with upper urinary tract tumors.
- All surgeries were completed without converting to open surgery, and there was no major complications, highlighting the technique's safety and effectiveness.
- Results indicated a median operative time of 230 minutes, minimal blood loss, and a median hospital stay of 8 days, showcasing favorable outcomes despite the small sample size.
RAS Family Gene Mutations, Clinicopathological Features, and Spread Patterns of Inverted Urothelial Papilloma of the Bladder.
Am J Surg Pathol
April 2024
Division of Pathology, The Cancer Institute.
Article Synopsis
- * In a study involving 39 IUP cases, researchers found that 87% had oncogenic mutations in RAS family genes, particularly HRAS, which was linked to smoking and specific morphological traits, while KRAS mutations were only found in non-smokers.
- * The study revealed no cases of recurrence or progression to cancer during follow-up, emphasizing the role of RAS mutations in IUP development and their relationship to different tumor subtypes and spread patterns.
[Significance of TERT promoter mutation in differential diagnosis of non-invasive inverted urothelial lesions of bladder].
Zhonghua Bing Li Xue Za Zhi
December 2023
Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Article Synopsis
- - This study analyzes the role of mutations in the TERT promoter gene in different types of inverted urothelial lesions in the bladder, aiming to improve differential diagnosis from 2016 to 2022.
- - A total of 32 patients were examined, revealing no TERT mutations in less aggressive lesions like florid glandular cystitis and inverted urothelial papilloma, while mutation rates increased with malignancy, particularly in nested subtype urothelial carcinoma where all tested cases exhibited mutations.
- - The prevalent mutation types in the cases analyzed were primarily C228T and C250T, indicating that combining tumor morphology with TERT mutation analysis can aid in distinguishing between benign and malignant urothelial lesions.
Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway.
Sci Rep
November 2023
Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- Bladder cancer is a prevalent type of cancer with significant treatment costs, and research is focusing on the human amniotic membrane (hAM) for its potential anticancer benefits.
- Studies show that hAM extracts can inhibit key markers related to cancer progression and migration in bladder cancer cells, indicating a dose-dependent effect on these processes.
- The findings suggest that hAM's ability to downregulate important cancer-related signaling pathways could lead to new therapeutic strategies and support ongoing drug development efforts.
Article Synopsis
- Advanced bladder squamous cell carcinoma (aBSCC) is a rare type of bladder cancer, and researchers studied its genomic alterations (GAs) in relation to human papilloma virus (HPV) status.
- Out of 171 aBSCC samples analyzed, 11 (6.4%) were HPV-positive, predominantly affecting younger women, with significant differences in genomic alterations between HPV+ and HPV- tumors, particularly in mutations related to tumor suppressor genes.
- Notably, markers associated with immunotherapy did not show significant differences between the two groups, and the absence of MTAP loss in HPV+ cases indicates a potential divergence in treatment options.
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Nat Commun
September 2023
State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
Article Synopsis
- The study analyzes 448 samples from 190 patients to understand the complex progression of urothelial bladder cancer (UC) across various stages and grades.
- Proteogenomic findings suggest that HRAS mutations influence signaling pathways that lead to different tumor types, particularly distinguishing between urothelial papilloma and papillary urothelial cancer (PUC).
- Key insights reveal that DNA damage is crucial in carcinoma in situ (CIS) progression, while specific metabolic changes and immune responses differ between PUC and CIS, which could inform future clinical practices.
A retrospective study on expression and clinical significance of PHH3, Ki67 and P53 in bladder exophytic papillary urothelial neoplasms.
PeerJ
July 2023
Department of Clinical Pathology, Weifang Medical University, Weifang, Shandong, China.
Article Synopsis
- Exophytic papillary urothelial neoplasms (EPUN) have varied prognoses and can be hard to diagnose, highlighting the need for better diagnostic markers like PHH3, which reflects mitotic activity in tumors.
- This study assessed PHH3 expression in different types of EPUN (high-grade, low-grade, low malignant potential, and papilloma) and compared it with other proteins, Ki67 and P53, using a sample of 101 cases.
- Findings indicated that PHH3 correlates strongly with mitotic counts and Ki67 across various EPUN types, suggesting its potential role in diagnosing and predicting outcomes for these tumors.
Pneumovesicoscopic management of bladder neoplasms in children: three case reports.
Pediatr Med Chir
July 2023
Pediatric Surgical Unit Salesi Children's Hospital, Ancona; Università Politecnica delle Marche, Ancona.
Article Synopsis
- Urothelial bladder neoplasms (UBN) are rare in children and lack established treatment guidelines, making management difficult.
- Pneumovesicoscopy shows promise as a potential treatment option for some pediatric UBN cases based on its past use in other urological conditions.
- The authors report successful use of pneumovesicoscopy in three pediatric cases, effectively excising a papilloma and biopsying a botryoid rhabdomyosarcoma, highlighting its viability as an alternative technique.
Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Am J Clin Oncol
September 2023
Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- * Researchers analyzed archived tissue samples from patients diagnosed between 2005 and 2020, comparing inverted tumors with traditional types to assess differences in recurrence rates and survival.
- * Findings revealed that inverted tumors have significantly lower recurrence rates, particularly for less aggressive forms, and high disease-free survival rates over 2 and 5 years compared to other tumor types.
Bladder squamous cell carcinoma in situ in the background of condyloma acuminatum in a kidney transplant recipient.
Can J Urol
April 2023
Division of Urology, Department of Surgery, University of Massachusetts Chan Medical School Baystate, Springfield, Massachusetts, USA.
Article Synopsis
- Condyloma acuminatum and squamous cell carcinoma in situ (CIS) in the bladder are rare occurrences, especially in developed nations where bladder cancer is generally uncommon.
- The diagnosis of squamous bladder lesions is complicated by their similar morphological features, making accurate identification challenging.
- A case is presented involving a 79-year-old man with a kidney transplant and a history of anal SCC, who developed bladder squamous cell CIS linked to condyloma acuminatum.
Cytomorphologic visualization of circulating tumor cells in urinary bladder cancer patients using ScreenCell™ technology: Potential as a simple cytology test.
Diagn Cytopathol
July 2023
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, India.
Article Synopsis
- Circulating tumor cells (CTCs) are important for predicting outcomes in solid tumors, but traditional detection methods can be costly and complicated.
- In a study of 24 patients suspected of having Urinary Bladder Cancer, a new, simpler detection method using filtration technology and routine staining was employed to identify CTCs.
- The results indicated that the presence of CTCs is significantly linked to tumor invasion and stage, potentially highlighting their value in diagnosing and predicting the prognosis of urinary bladder cancers, although further research with larger samples is needed.
The complexity of human papilloma virus in cancers: a narrative review.
Infect Agent Cancer
February 2023
Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Article Synopsis
- Human papillomavirus (HPV) is a significant oncovirus linked to several cancers, particularly cervical and anal cancers, as well as being a risk factor for others like colorectal and head and neck cancers.
- The research spanned publications from 2000 to 2022, utilizing databases like Scopus and PubMed, to gather evidence on HPV's role in tumor development.
- HPV promotes cancer by using its E6 and E7 oncoproteins to inhibit important tumor suppressors, P53 and Rb, leading to molecular changes associated with various malignancies.
Invasive urothelial carcinoma with squamous differentiation and associated high-risk human papilloma virus infection: Clinical, cytologic, and histologic features of a rare entity.
Ann Diagn Pathol
April 2023
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Article Synopsis
- The study examines the relationship between Fine Needle Aspiration (FNA) cytology results and histological features of a rare case of high-grade urothelial carcinoma with squamous differentiation linked to high-risk HPV infection.
- A 69-year-old woman presented with urinary issues and was found to have invasive carcinoma after diagnostic procedures, despite minimal prior catheterization.
- The findings highlight the importance of cytopathology in identifying unique cases of cancer, particularly in patients without extensive medical histories typically associated with such lesions.
Clear evidence of the carcinogenic potential of anthracene: A 2-year feeding study in rats and mice.
Environ Toxicol
March 2023
Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Kanagawa, Japan.
Article Synopsis
- Anthracene is an environmental pollutant that has raised concerns over its potential chronic toxicity and carcinogenic effects on humans, although evidence is lacking.
- A study adhered to OECD guidelines investigated the long-term effects of anthracene on F344 rats and BDF1 mice, with varying exposure levels over 104 weeks.
- Findings revealed that while there was no significant impact on survival rates, anthracene exposure led to increased incidences of various cancers and pre-neoplastic lesions in treated animals, indicating its carcinogenic potential.
Evaluation of APOBEC3 expression as prognostic marker in squamous cell carcinoma of the penis.
Sci Rep
July 2022
Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Squamous cell carcinoma of the penis (PSC) is a rare disease with limited information on the molecular events leading to malignant transformation. In a third of PSC cases, presence of human papilloma virus (HPV) is found. The APOBEC3 family of proteins is known to play a significant role in defense against HPV infection, but their role in PSC is largely unknown.
View Article and Find Full Text PDFHigh prevalence of p16 staining in malignant tumors.
PLoS One
July 2022
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- * The highest levels of p16 positivity were found in specific cancers like uterine cervix squamous cell carcinomas (94.4%) and Merkel cell carcinoma (97.7%), with all tumor types showing some degree of p16 staining.
- * A significant correlation between p16 positivity and HPV status was identified, with 80.4% of p16 positive squamous cell carcinomas testing HPV positive, suggesting that strong p16 expression can indicate malignancy, although its use
Persistently elevated β-human chorionic gonadotropin level after vacuum-assisted uterine aspiration: a case report.
J Med Case Rep
July 2022
Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Article Synopsis
- A case study details a 49-year-old woman who experienced elevated β-hCG following an incomplete abortion, leading to an extensive medical work-up that ultimately revealed urothelial carcinoma.
- The findings highlight the importance of considering urologic issues like urothelial carcinoma in patients with elevated β-hCG, especially when they show relevant risk factors, despite it being an uncommon cause.
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats.
Toxicol Sci
August 2022
Division of Pathology, National Institute of Health Sciences, Kawasaki-ku, Kawasaki 210-9501, Japan.
Article Synopsis
- - The study examined the formation of γ-H2AX, a marker for DNA damage, and various stem cell markers in rats with bladder tumors induced by the chemical BBN, finding that initial bladder cell hyperplasia reverted to normal but eventually led to malignant tumors. - Histological analyses showed that even after stopping BBN exposure, there were persistent high levels of γ-H2AX and stem cell markers like ALDH1A1 and CD44 in what appeared to be normal bladder tissue, alongside ongoing inflammation. - The research indicated that genes associated with inflammation, particularly Stat3 and Myc, remained active long after BBN treatment, suggesting their role in tumor development from stem cell-positive cells influenced by early DNA damage.
Histopathologic findings in patients who have undergone blue light cystoscopy and bladder biopsy or transurethral resection: A contemporary clinicopathologic analysis of 100 cases.
Pathol Res Pract
June 2022
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033, USA. Electronic address:
Article Synopsis
- Blue light cystoscopy helps urologists detect potentially malignant bladder lesions that standard cystoscopy might miss, but there’s limited research on the accuracy of this method, especially concerning false positives.
- A study from 2017 to 2021 evaluated 100 patients, mostly older men, and found that 69 cases were malignant, prominently high-grade urothelial carcinoma, and 31 were benign lesions, highlighting the mix of findings from the procedure.
- Understanding the correlation between the histopathological results and blue light cystoscopy could be crucial for improving patient management and developing better monitoring strategies for those undergoing this type of examination.
Squamous cell papilloma a rare urinary bladder tumor, case report and operative video.
Urol Case Rep
July 2022
Department of Urology, Hamad Medical Corporation, Doha, Qatar.
Article Synopsis
- A case study is presented about a 39-year-old male with a rare benign squamous cell papilloma in his bladder, which appeared as a cauliflower-like mass that could be mistaken for cancer.
- The tumor exhibited characteristics such as extensive keratinization and no signs of nuclear atypia or stromal invasion, confirming its benign nature.
- The manuscript includes a summary of this case along with the first operative video showing the transurethral resection of the papilloma and treatment of associated bladder stones.