11,554 results match your criteria: "Squamous Cell Carcinoma* Dermatology"
J Am Acad Dermatol
December 2024
University of Vermont Medical Center, Division of Dermatology.
Background: Treatment of cutaneous squamous cell carcinoma largely involves surgical excision. Few studies have examined oncologic outcomes of tumors managed by watchful waiting when the lesion appears resolved after the biopsy site has healed.
Objective: To describe oncologic outcomes for patients diagnosed with cutaneous squamous cell carcinoma that was determined clinically resolved at follow-up and subsequently managed by watchful waiting.
Clin Transl Oncol
December 2024
Fundación ECO (Excelencia y Calidad en Oncología), Madrid, Spain.
Background: There are gaps and unanswered questions in clinical guidelines regarding several aspects of the management of patients with cutaneous squamous cell carcinoma (cSCC).
Methods: A scientific committee of ten cSCC specialists in Spain (dermatology, medical oncology, oral and maxillofacial surgery, plastic surgery, and radiotherapy) used ADAPTE methodology to develop recommendations by: (i) identifying clinical questions not fully answered by clinical practice guidelines; (ii) systematically reviewing the literature (published between November 2017 and July 2023 in PubMed and the Cochrane database) and grading the evidence (using Oxford levels); (iii) developing recommendations and assessing those with no consensus among the scientific committee or with evidence level 3-5 or strength of recommendation under C or D in a two-round Delphi method; and (iv) developing the final recommendations in the form of answers to key clinical questions, grading the strength of recommendation. An external group of 32 experts plus the members of the committee participated in both Delphi rounds, evaluating the appropriateness and need of the recommendations.
Clin Cosmet Investig Dermatol
December 2024
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, 510095 People's Republic of China.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by enhancing the immune system's ability to target cancer cells. However, ICIs can lead to immune-related adverse events (irAEs), including dermatologic manifestations such as bullous pemphigoid (BP).
Objective: To evaluate the efficacy and safety of omalizumab and other biologics in the treatment of ICI-induced refractory bullous pemphigoid and to derive a strategy for selecting biologic treatments for this condition.
Semin Plast Surg
November 2024
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Mohs micrographic surgery (MMS) is a tissue-sparing skin cancer resection technique that involves 100% margin analysis. This procedure is performed in the outpatient setting under local anesthesia by dermatologic surgeons who act as both the surgeon and the pathologist. The technique allows for prompt reconstruction immediately after cancer clearance and offers the highest cure rate for many skin malignancies, including basal and squamous cell carcinoma, as well as more rare tumors.
View Article and Find Full Text PDFDermatol Reports
November 2024
Department of Dermatology, ASST Spedali Civili di Brescia, University of Brescia, Italy.
This article presents a case study of a novel modification of the A-T flap, known as "Sorting Hat" flap, employed in dermatologic surgery for facial reconstruction. In the treatment of an 89-year-old male's squamous cell carcinoma lesion on the forehead, the "Sorting Hat" flap, introduced as an innovative alternative, eliminates the need for Burrow triangles and relies on flap shape for inconspicuous scarring and favorable cosmetic outcomes.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Orlando College of Osteopathic Medicine, Winter Garden, FL 34787, USA.
Background: Non-melanoma skin cancers (NMSCs) are the most common cancers in the United States. Image-guided superficial radiation therapy (IGSRT) is an effective treatment for NMSCs. Patient comorbidities and socioeconomic status (SES) are known contributors to health disparities.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gröna stråket 16, Gothenburg, SE-413 45, Sweden.
Background: Darier disease is a genodermatosis which manifests as hyperkeratotic papules and superficial erosions mainly in seborrheic skin areas. This retrospective registry-based cohort study aimed to estimate the association between Darier disease and skin cancer.
Results: Patients diagnosed with Darier disease were identified from the patient registry of Sahlgrenska University Hospital (Gothenburg, Sweden) in 2016-2020.
bioRxiv
December 2024
Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA.
Immune checkpoint inhibitors such as anti-PD-1 antibodies (aPD1) can be effective in treating advanced cancers. However, many patients do not respond and the mechanisms underlying these differences remain incompletely understood. In this study, we profile a cohort of patients with locally-advanced or metastatic basal cell carcinoma undergoing aPD-1 therapy using single-cell RNA sequencing, high-definition spatial transcriptomics in tumors and draining lymph nodes, and spatial immunoreceptor profiling, with long-term clinical follow-up.
View Article and Find Full Text PDFJ Dermatol
December 2024
Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Comprehensive studies of the genetic profiles of cutaneous squamous cell carcinoma (cSCC) in Japanese patients have been lacking, although an understanding of these profiles is crucial for improving treatment outcomes. Since 2019, comprehensive genomic profiling (CGP) has been covered by Japan's health insurance, and the resulting data have been compiled into a comprehensive database by the country's Center for Cancer Genomics and Advanced Therapeutics (C-CAT). In this retrospective study, we used CGP data from the C-CAT database to analyze genomic characteristics of cSCC in Japanese patients.
View Article and Find Full Text PDFArch Dermatol Res
December 2024
Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.
Arch Dermatol Res
December 2024
Department of Dermatology, The Affiliated Hospital of Inner Mongolia Medical University, Xinhua Street, Hohhot, 010030, China.
Tumor-derived exosomes that transport MicroRNAs significantly influence cutaneous squamous cell carcinoma(CSCC) progression. However, the molecular mechanisms of exosomal MicroRNA-31 regulation of CSCC are mostly undefined. To determine whether a targeting relationship exists between MicroRNA-31 (miR-31) in CSCC-derived exosomes and the tumor suppressor RhoBTB1, and the regulatory effect of the relationship on tumor cells.
View Article and Find Full Text PDFJMIR Dermatol
December 2024
Department of Dermatology, Lewis Katz School of Medicine, Temple University, 225 Market Street, Philadelphia, PA, 19106, United States, 1 215-482-7546.
Cureus
November 2024
Department of Dermatology, JR Sapporo Hospital, Sapporo, JPN.
Bullous pemphigoid (BP) is a chronic autoimmune disorder characterized by subepidermal blister formation, primarily affecting elderly individuals. While BP has been associated with malignancies, the exact nature of this relationship remains unclear. We report the case of a 72-year-old man who presented with pruritic cutaneous lesions, including tense vesicles and bullae and was diagnosed with BP.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
December 2024
Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany.
Background: In actinic keratosis (AK), field cancerization describes areas of skin where multiple visible AK lesions are surrounded by healthy looking skin containing non-visible (subclinical) lesions. As all AK lesions have a risk of progression to cutaneous squamous cell carcinoma, experts advise field-directed treatment. Photodynamic therapy (PDT) is an effective field-directed treatment option for AK; however, long-term efficacy data are still scarce.
View Article and Find Full Text PDFAm J Dermatopathol
November 2024
Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT.
BMJ Open
December 2024
Department of Dermatology, The First Affiliated Hospital of Jinan University and Jinan University Institute of Dermatology, Guangzhou, China
Skin Appendage Disord
December 2024
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor.
Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma.
Cureus
November 2024
Dermatology, University of Texas Medical Branch at Galveston, Galveston, USA.
Dr. Frederic E. Mohs significantly advanced the treatment of skin cancer with the development of Mohs micrographic surgery (MMS).
View Article and Find Full Text PDFAm J Surg Pathol
December 2024
Departments of Pathology.
Dermatol Pract Concept
October 2024
Department of Pathology, Cruces University Hospital, Barakaldo, Biscay, Spain.
Dermatol Pract Concept
October 2024
Department of Dermatology, Weill Cornell Medicine, New York.
Indian J Dermatol
October 2024
Department of Dermatology, The Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
Verruciform xanthomas are rare lesions affecting 0.025-0.5% of the population.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
December 2024
The Fifth People's Hospital of Hainan Province,Haikou City, Hainan Province, China. Electronic address:
Verrucous carcinoma, a well-differentiated variant of squamous cell carcinoma with low-grade malignancy, is often associated with localized human papillomavirus (HPV) infection and excessive penile foreskin. We report a 45-year-old male who presented with a verrucous plaque on the glans penis for over four months, along with itching. Examination revealed a verrucous, erosive lesion with a cauliflower-like surface, firm texture, and irregular shape, accompanied by pain, bleeding, and a foul odor.
View Article and Find Full Text PDFJ Dermatol Sci
November 2024
Henry Ford Health + Michigan State University Health Sciences, Detroit, MI, USA; Department of Dermatology, Henry Ford Health, Detroit, MI, USA; Center for Cutaneous Biology and Immunology, Henry Ford Health, Detroit, MI, USA; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA. Electronic address:
Indian Dermatol Online J
October 2024
Department of Dermatology and Venereology, AIIMS, Habibganj, Saketnagar, Bhopal, Madhya Pradesh India.