7,110 results match your criteria: "Sports Traumatology & Minimally Invasive Articular Surgery Center[Affiliation]"

Eupalinolide A attenuates trauma-induced heterotopic ossification of tendon in mice by promoting YAP degradation through TOLLIP-mediated selective autophagy.

Phytomedicine

December 2024

Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus at TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany; University Center of Orthopaedic, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at TUD Dresden University of Technology, Dresden, Germany. Electronic address:

Article Synopsis
  • - This study explores how eupalinolide A (EA) can prevent abnormal bone formation in tendon-derived stem cells (TDSCs), which is important for treating traumatic heterotopic ossification (HO).
  • - EA was found to inhibit the osteogenic differentiation of TDSCs by targeting the YAP signaling pathway, promoting YAP's degradation through a specific autophagy pathway.
  • - In mouse models, local injections of EA successfully reduced tendon HO following trauma, highlighting its potential as a therapeutic agent and suggesting that targeting HECW1 involved in YAP degradation could be a new treatment strategy.
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  • Freiberg disease (FD) is an osteochondrosis condition mainly affecting the second metatarsal head, and this study compares two treatment options: Dorsiflexion Closing Wedge Osteotomy (DCWMO) and Osteochondral Autologous Transplantation (OAT).
  • The research involved 16 patients split into two groups — 8 receiving OAT and 8 receiving DCWMO — with various outcome measures like complications, range of motion, and functional scores being assessed.
  • Results showed that while both treatments improved functions, OAT had better scores in sport and activity-related functions, and plantarflexion, whereas DCWMO showed a higher AOFAS-LMI score, indicating distinct advantages for each method in
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  • Forearm shaft fractures in children are common and often result from falls, with elastic stable intramedullary nailing (ESIN) being the preferred treatment method in pediatric cases.
  • A study involving 201 patients showed that ESIN resulted in successful bone union and satisfactory alignment post-treatment, with most injuries occurring during sports.
  • Although the overall complication rate was 11.4%, complications were more frequent among patients who underwent open reduction internal fixation, highlighting ESIN as a safer option.
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  • * Research indicates that PARP12 promotes OA by inhibiting mitophagy in cartilage, interacting with ISG15, and affecting the modifications of mitofusin proteins, leading to cartilage degradation and disease progression.
  • * The activation of PARP12 is influenced by inflammatory signals through the IRF1 pathway, and targeting PARP12 could offer new therapeutic strategies for managing OA, with its levels potentially serving as a predictor for disease severity.
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Tears of the pectoralis major tendon have become more common due to the rising popularity of weightlifting and contact sports, yet they have not been described in young adolescents. A 13-year-old female high-level gymnastic athlete presented with left shoulder pain after a fall off the uneven bars. After excluding other diagnoses, magnetic resonance imaging (MRI) revealed a pectoralis major tendon tear.

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The present data contribute to the specialties of Sports Dentistry and Implantology, offering scientific evidence of the importance of a mouthguard to provide the best protection for athletes rehabilitated with dental implants.

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Sparse and inconsistent reporting of pre- and post-operative radiographic angles of total knee arthroplasty using true unrestricted kinematic alignment: An umbrella review and secondary meta-analysis.

Knee Surg Sports Traumatol Arthrosc

October 2024

Department of Orthopaedic Surgery and Traumatology, Kantonsspital Baselland (Bruderholz, Liestal, Laufen), Bruderholz, Switzerland.

Purpose: To identify, synthesise and critically appraise findings of systematic reviews and meta-analyses on pre- and post-operative radiographic angles (lateral distal femoral angle [LDFA], medial proximal tibial angle [MPTA] and hip-knee-ankle [HKA] angle) of unrestricted kinematic alignment versus mechanical alignment in total knee arthroplasty (TKA).

Methods: Two authors searched MEDLINE, EMBASE and Epistemonikos for systematic reviews, with or without meta-analyses, that reported on TKA outcomes using unrestricted kinematic alignment. The methodological quality of the included systematic reviews and meta-analyses was independently assessed using A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2).

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SDIMMMER is an acronym intended for use in both clinical practice and medical research. It facilitates a comprehensive evaluation of a patient's metabolic profile and serves as a mnemonic for the following key assessment areas: Sleep, Diet, Microbiome, Metabolism, Medications, Exams, and Rehabilitation. In the clinical setting, SDIMMMER's primary objective is to monitor and manage the patient's metabolic status, particularly targeting low-grade chronic systemic inflammation, a hallmark of metabolic syndrome (MS).

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Article Synopsis
  • - Talar avascular necrosis (AVN) often develops after severe talar neck fractures, with early detection being vital to prevent serious damage; conditions like diabetes and systemic lupus can contribute to AVN risk.
  • - Initial stages of AVN (I-II) can often be treated non-surgically, while advanced stages (III-IV) may require more invasive procedures like hindfoot arthrodesis or total talar replacement (TTR).
  • - The rise of advanced prosthetics through 3D printing is improving the success rate of TTR, which offers benefits like reduced pain, fewer complications, and preservation of limb length compared to traditional joint-sacrificing procedures.
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The Coronal Plane Alignment of the Knee (CPAK) classification is a pragmatic distribution of nine phenotypes for coronal knee alignment that can be used on healthy and arthritic knees. Our study aimed to describe the CPAK distributions in a Spanish southeast osteoarthritic population and compare them to other populations' published alignment distributions. Full-leg standing X-rays of the lower limb from 528 cases originating from the so-called Vega Alta del Segura (southeast of the Iberian Peninsula) were retrospectively analysed.

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: Data regarding fungal PJIs of the shoulder are scarce. The present systematic review aims to identify and evaluate all published shoulder fungal PJIs in an effort to better understand the diagnostic and therapeutic approach to these infections. : A systematic review according to the PRISMA guidelines was conducted, locating all shoulder fungal PJIs.

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The buffy-coat, a layer of leukocytes and platelets obtained from peripheral blood centrifugation, plays a crucial role in tissue regeneration and the modulation of inflammatory responses. This article explores the mechanisms of regenerative inflammation, highlighting the critical role of the buffy-coat in influencing macrophage polarization and its therapeutic potential. Macrophage polarization into M1 and M2 subtypes is pivotal in balancing inflammation and tissue repair, with M1 macrophages driving pro-inflammatory responses and M2 macrophages promoting tissue healing and regeneration.

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mG-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes.

Biomaterials

March 2025

Department of Sports Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. Electronic address:

N7-methylguanosine (mG) modification is one of the most prevalent RNA modifications, and methyltransferase-like protein-1 (METTL1) is a key component of the mG methyltransferase complex. METTL1-catalyzed mG as a new RNA modification pathway that regulates RNA structure, biogenesis, and cell migration. Increasing evidence indicates that mG modification has been implicated in the pathophysiological process of osteoarthritis (OA).

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Rebuilding Stability: Exploring the Best Rehabilitation Methods for Chronic Ankle Instability.

Sports (Basel)

October 2024

Physical Therapy and Rehabilitation Unit, Policlinico di Modena, 41124 Modena, Italy.

Chronic Ankle Instability (CAI) is a common condition characterized by repeated episodes of ankle "giving way" and impaired balance, leading to functional limitations. Various rehabilitation techniques, including balance training, proprioceptive exercises, whole-body vibration (WBV), and novel approaches like stroboscopic vision, are used to address these deficits. This review evaluates the effectiveness of different rehabilitation interventions for CAI management.

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: This study investigated the behavior of postural adjustments throughout the entire action: from the preparatory phase (anticipatory postural adjustment, APA), the focal movement phase (online postural adjustments, OPA), to the compensatory phase (compensatory postural adjustment, CPA) while raising the arms in a standing position, both with eyes opened and closed. The goal was to analyze the effects of reduced sensorial information and different heights on postural muscle activity during these three phases. : Eight young women performed rapid shoulder flexion while standing on the ground and on a 1-m elevated platform.

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The Use of Social Media in Orthopedic and Trauma Surgery Education: A Cross-Sectional Survey of German-Speaking Residents and Medical Students.

Healthcare (Basel)

October 2024

Department of Orthopedic and Trauma Surgery, Orthopädische Klinik Paulinenhilfe, Diakonieklinikum, Rosenbergstrasse 38, 70192 Stuttgart, Germany.

Background/objectives: Social media has become a significant part of daily life, with platforms like Facebook and WhatsApp dominating usage. The COVID-19 pandemic further increased social media activity, including within the orthopedic community due to restrictions on physical gatherings. Despite the benefits of instant access to educational resources and interaction with experts, the lack of regulated editorial oversight on social media raises concerns about misinformation and privacy.

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Bone marrow cellular therapy has undergone a remarkable evolution, significantly impacting the treatment of musculoskeletal disorders. This review traces the historical trajectory from early mythological references to contemporary scientific advancements. The groundbreaking work of Friedenstein in 1968, identifying fibroblast colony-forming cells in bone marrow, laid the foundation for future studies.

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Course and Predictors of Adult Spinal Sagittal Disorders: A 10-year Prospective Case Series.

Spine (Phila Pa 1976)

October 2024

Department of Orthopaedics and Traumatology, Hospital Nova, Wellbeing services county of Central Finland.

Article Synopsis
  • The study aimed to track the progression of adult spinal deformity (ASD) over a decade, focusing on factors that affect spinal alignment.
  • It involved analyzing full spine radiographs of 204 participants, showing a significant overall deterioration in spinal condition, with only 13% of participants experiencing improvement.
  • Key predictors for changes in spinal alignment included low scores on self-assessment questionnaires related to function and severe pelvic tilt, emphasizing the need for personalized treatment approaches based on individual risk factors.
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Lesser Metatarsophalangeal Joint Instability: Open Surgery Treatment Alternatives.

Foot Ankle Clin

December 2024

Orthopedic & Traumatology Department, Federal University of São Paulo - Brazil, Foot and Ankle Clinic.

Lesser metatarsophalangeal joint plantar plate degeneration and tear typically presents as an attritional pattern of capsuloligamentous deficiency in middle-aged patients or sports-related chronic injuries. Knowledge of the anatomy, pathophysiological basis, common patterns, grading and classification of these injuries, and indications for surgery will aid imaging interpretation in the preoperative setting. The acuity and extent of injury, tissue quality, and functional requirements of the patient influence clinical decision-making with respect to surgical management.

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Purpose: Posterior elongation of the physiological terminal sulcus (TS) due to lateral femoral condyle impaction fracture (LFC-IF) after an anterior cruciate ligament (ACL) tear could potentially decrease the weight-bearing area of the tibiofemoral joint, decrease the tension on lateral meniscus and cause flattening of the LFC which would influence rotational knee motion and cause anisometry of the lateral and anterolateral stabilizers. Therefore, the purpose of the study was to assess if the LFC-IF elongates the physiological TS posteriorly.

Methods: One hundred patients magnetic resonance images (MRIs) (75 males, 25 females, mean age 32.

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This review critically examines the issue of thigh tendon reinjury in athletes, drawing on recent advancements and diverse perspectives in sports medicine. The findings underscore the paramount importance of an early and accurate diagnosis, which significantly influences treatment efficacy and rehabilitation outcomes. We explore the intricacies of tendon anatomy and the mechanisms underlying injuries, highlighting how these factors interplay with athlete-specific risk profiles to affect reinjury rates.

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