2,663 results match your criteria: "Sporotrichosis"

Sporotrichosis during pregnancy: A retrospective study of 58 cases in a reference center from 1998 to 2023.

PLoS Negl Trop Dis

December 2024

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Rio de Janeiro, Brazil.

Background: Pregnant women constitute a vulnerable population occasionally affected by zoonotic sporotrichosis. Treatment is challenging due to potentially teratogenic oral medications (itraconazole and saturated potassium iodide solution) or lack of clinical experience during pregnancy (terbinafine). Literature is scarce on sporotrichosis and pregnancy, mainly consisting of case reports.

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Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii.

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Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.

Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.

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Sporotrichosis.

J Pediatr

December 2024

Department of Pediatric Infectious Diseases, Valley Children's Healthcare Madera CA 93636. Electronic address:

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Article Synopsis
  • * A study in Manaus identified that 89.3% of sporotrichosis patients had S. brasiliensis, primarily impacting women with an average age of 44.5 years, and many reported prior contact with cats.
  • * The research concluded that cats are major vectors for this zoonotic disease in the Amazon, emphasizing the need for sanitation, education, and responsible pet ownership to control its spread.
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Article Synopsis
  • Low-density neutrophils (LDNs) are a unique subset of neutrophils that play a role in systemic infections, but their specific function in subcutaneous fungal infections like sporotrichosis had not been studied until now.
  • This research found higher neutrophil counts in sporotrichosis patients, along with increased levels of granulocyte colony-stimulating factor (G-CSF), and a notable rise in CD16+CD66b+ LDNs compared to healthy individuals.
  • Additionally, LDNs showed impaired functions, with reduced ability to respond to infections, which correlates with disease severity in patients suffering from sporotrichosis.
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Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in Infection: Case Report.

Microorganisms

October 2024

Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil.

Sporotrichosis is a subcutaneous infection caused by fungi from the genus , among which displays high virulence and transmissibility. So far, classical antifungal agents have been efficient against , but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole.

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We analyzed clinical manifestations, antifungal susceptibility, and treatment outcomes of cutaneous sporotrichosis in Thailand during 2018-2022. The study included 49 patients whose mean age was 58.7 (SD 16.

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Epidemiologic and Clinicopathological Characterization of Feline Mammary Lesions.

Vet Sci

November 2024

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.

Most lesions found in the mammary glands of cats are malignant, with aggressive behavior and unfavorable prognosis. Studies on the epidemiologic and clinicopathological characteristics of mammary lesions in cats are scarce. The present study aimed to evaluate those characteristics and to correlate them with survival in cats.

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Photodynamic therapy reduces viability, enhances itraconazole activity, and impairs mitochondrial physiology of Sporothrix brasiliensis.

Microbes Infect

November 2024

Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Rede Micologia RJ - FAPERJ, Rio de Janeiro, Brazil. Electronic address:

Sporothrix brasiliensis is the main agent of sporotrichosis in Brazil, with few therapeutic options. This study aimed to investigate the in vitro efficacy of photodynamic therapy using a diode laser (InGaAIP) in combination with the photosensitizer methylene blue against S. brasiliensis yeasts.

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Sporotrichosis is a subacute or chronic infection affecting subcutaneous tissues, caused by the dimorphic fungus spp. This case series discusses three instances of ocular adnexal sporotrichosis treated at a tertiary government hospital in Pahang, Malaysia. It highlights diagnostic challenges, management strategies, and the impact of misdiagnosis and underreporting in the Southeast Asian tropical region compared to other parts of the world.

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The Emergence of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Piauí, Brazil.

Zoonoses Public Health

November 2024

Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Introduction: In Brazil, the emergence of feline sporotrichosis, a neglected subcutaneous mycosis primarily transmitted by cats and caused by the fungus Sporothrix brasiliensis, has been monitored via molecular tools. This approach underscores the geographic expansion of this disease and highlights the critical role of molecular surveillance in understanding its epidemiology and guiding public health interventions.

Methods: We investigated three domestic cats (Felis catus) with multiple skin lesions in Picos, Piauí, Brazil.

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Article Synopsis
  • Sporotrichosis is a serious fungal disease caused by Sporothrix spp., leading to potential skin lesions and even death; there’s a growing need for better treatment options due to limited antifungal therapies and their side effects.
  • This study examined the effectiveness of Photodynamic Inactivation (PDI) using curcumin and combining it with antifungal agents like itraconazole and ketoconazole to combat these fungi.
  • Results showed that PDI, especially in combination with low doses of antifungals and curcumin, could completely inactivate Candida albicans, Sporothrix brasiliensis, and Sporothrix schenckii, suggesting it could be a viable treatment alternative for sporotrichosis.
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Bariatric surgery complicating the treatment of choice for Sporotrichosis: report of two cases.

An Bras Dermatol

November 2024

Mycology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil; Postgraduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. Electronic address:

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To investigate differences in the clinical features of patients with sporotrichosis and cutaneous Mycobacterium marinum infection, and develop a prediction model for the initial identification. A total of 121 patients were selected based on the results from etiological culture. Logistic regression analyses were employed to identify the most valuable variables.

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Fixed Facial Sporotrichosis.

Indian J Pediatr

October 2024

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, P.R. China.

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Sporothrix and Sporotrichosis: A South African Perspective on a Growing Global Health Threat.

Mycoses

October 2024

Department of Biochemistry, Genetics and Microbiology, Forestry and Agricultural Biotechnology Institute (FABI), University of Pretoria, Pretoria, South Africa.

Sporotrichosis is a disease that arises from a fungal infection caused by members of the Ascomycete genus Sporothrix. The disease has a unique history in South Africa, due to an association with gold mines, where large numbers of mine workers were infected in the 1930s and 1940s. This was likely driven by hot humid conditions and timber supports used in these mine shafts.

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Article Synopsis
  • Sporotrichosis is a common deep fungal infection that currently lacks fast and accurate diagnostic techniques; this study investigates a new method using FTA cards and nested PCR for diagnosis.
  • The study involved 26 patients with skin lesions diagnosed with sporotrichosis, using various control groups for comparison and applying nested PCR and histopathological examinations to assess the results.
  • The testing yielded a 30.8% positive rate through PCR in actual patients, while fungal fluorescence staining improved detection sensitivity to 65.4%, indicating the method's potential effectiveness despite its relatively low initial positive rate.
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Rationale: Mycobacterium marinum (M marinum), a slow-growing nontuberculous mycobacterium (NTM), is widely distributed in aquatic environments. It is a well-known cutaneous pathogen, which causes sporotrichosis-like lesions.

Patient Concerns: In this report, we describe 2 cases of subcutaneous M marinum infection.

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Sporotrichosis is caused by species of the fungus Sporothrix that affect human and several animal species. The transmission of sporotrichosis is classically from an environmental source following penetrating injury. The alternative zoonotic route has gained attention due to the rapid and significant spread of cat-transmitted sporotrichosis in South America and Malaysia, resulting in several thousand human and feline cases in recent decades, especially in Brazil.

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