193 results match your criteria: "Spontaneous Primary Ovarian Insufficiency and Premature Ovarian Failure"
Folliculogenesis resumption after ovarian cortex transplantation: what is the earliest hormonal indicator?
Arch Gynecol Obstet
December 2024
Department of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, CHU Lille, 59000, Lille, France.
Introduction: Ovarian tissue cryopreservation (OTC) is recommended by scientific societies for women undergoing highly gonadotoxic cancer treatments. Following transplantation, the restoration of ovarian function is typically characterised by the resumption of spontaneous menstruation. Yet, a few studies have looked at the longitudinal hormonal variations following transplantation.
View Article and Find Full Text PDFArticle Synopsis
Excess of severe autoimmune diseases in women with premature ovarian insufficiency: a population-based study.
Hum Reprod
November 2024
Department of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Pohde, Oulu, Finland.
Article Synopsis
- Research shows that women with premature ovarian insufficiency (POI) are significantly more likely to have a history of severe autoimmune diseases, occurring 2.6 times more often than those without POI.
- The study analyzed data from nearly 4,000 women diagnosed with spontaneous POI, comparing their health outcomes to over 15,000 matched controls, which included tracking autoimmune diagnoses from childhood through 2017.
- Findings indicate that women with POI not only had a higher prevalence of autoimmune disorders prior to their diagnosis but also faced a 2 to 3 times increased risk for these diseases for several years afterward.
Conception vessel acupuncture research regularity in the treatment of diminished ovarian reserve: a multi-center, large-sample prospective cohort study protocol.
Front Endocrinol (Lausanne)
September 2024
Department of Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Article Synopsis
- Diminished ovarian reserve (DOR) is a reproductive health issue characterized by a reduction in the number and quality of oocytes, potentially leading to premature ovarian failure; acupuncture and moxibustion are being explored as treatment options.
- A study enrolled 1,221 DOR patients over 12 weeks, dividing them into two groups: one receiving baseline treatment with conception vessel acupuncture and the other receiving baseline treatment only, tracking various reproductive health outcomes including anti-Müllerian hormone (AMH) levels.
- The findings aim to support the use of conception vessel acupuncture and moxibustion in improving DOR treatment effectiveness, providing both clinical evidence and theoretical foundations for future practices.
Article Synopsis
- - The study examined fertility preservation methods in 414 female lymphoma patients aged 18-40 diagnosed between 2010 and 2018, with most common cancer types being Hodgkin Lymphoma (74%) and various others.
- - Majority of the patients (71%) received ABVD as the first-line treatment, while fertility preservation strategies included GnRHa (78%), oral contraceptives, and cryopreservation of oocytes and ovarian tissue.
- - After treatment, 70% of women had regular menstrual cycles, 8% experienced premature ovarian failure, and there were 43 pregnancies observed during a median follow-up of 5 years, with age and treatment intensity being significant factors for amenorrhea and POF.
Endometriosis in a 22-Year-Old with Premature Ovarian Insufficiency Secondary to Pre-Pubertal Bone Marrow Transplant: a Case Report.
Reprod Sci
September 2024
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Article Synopsis
Efficacy of intra-ovarian injection of autologous platelet-rich plasma in women with poor responders: a systematic review and meta-analysis.
Arch Gynecol Obstet
June 2024
Urmia University of Medical Sciences, Urmia, Iran.
Article Synopsis
- - The study aimed to assess the effects of injecting autologous platelet-rich plasma (PRP) into ovaries on ovarian reserve and reproductive outcomes in women with poor ovarian response (POR).
- - A systematic review included 13 studies with 1289 patients, analyzing factors such as age, BMI, and infertility duration to evaluate PRP's effectiveness.
- - Results showed significant improvements in several ovarian reserve markers post-treatment, with increases in antral follicle count (AFC), anti-Müllerian hormone (AMH), and day 3 estradiol, alongside a decrease in follicle-stimulating hormone (FSH).
Ovarian tissue transplantation: 10 years of experience at the Bologna University.
Front Endocrinol (Lausanne)
March 2024
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Article Synopsis
- Ovarian tissue transplantation (OTT) is highly effective, with a 95% success rate in restoring ovarian function and over 200 live births reported globally, but lacks comprehensive data due to the absence of international registries.* -
- This study analyzed 30 women who underwent OTT at one center from December 2012 to June 2023, focusing on the recovery of ovarian function and fertility after the procedure, using hormonal tests and imaging methods for monitoring.* -
- Results showed that nearly all women with premature ovarian insufficiency (POI) experienced recovery of hormonal function post-OTT, with the best outcomes among those receiving heterotopic transplantation, indicating OTT's potential to address fertility issues effectively.*
A qualitative study of work and early menopause: 'On-the job' experiences and career trajectories.
Maturitas
April 2024
Monash Centre for Health Research and Implementation-MCHRI, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia; Department of Endocrinology, Monash Health, Clayton, Victoria, Australia. Electronic address:
Objectives: Early menopause or premature ovarian insufficiency (POI), menopause occurring before age 45 and 40 years respectively, occur at the age when most women are establishing or consolidating their careers. Studies of older postmenopausal women indicate an adverse bidirectional relationship between menopause and work. However, data are lacking regarding the work experiences of women with early menopause or POI.
View Article and Find Full Text PDFReproductive health in Turner's syndrome: from puberty to pregnancy.
Front Endocrinol (Lausanne)
December 2023
Infertility and IVF Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.
Article Synopsis
- Turner syndrome (TS) is a genetic condition affecting approximately 1 in 2,500 newborn females, marked by missing or altered X chromosomes and resulting in a variety of physical and developmental issues.
- Half of those with TS have a 45 XO karyotype, while others may have mosaicism or other chromosomal variations, making fertility a major concern due to accelerated germ cell death.
- Options for fertility preservation, like ovarian cortex cryopreservation and oocyte cryopreservation, are available for those with premature ovarian insufficiency (POI), which is relevant for managing reproductive challenges in women with TS.
Premature ovarian insufficiency and autoimmune profiles: a prospective case-control study.
Climacteric
April 2024
Department of Gynaecology, Imperial College Healthcare, NHS Trust, London, UK.
Article Synopsis
[Follow-up analysis of sex hormone levels and prognosis in women after hematopoietic stem cell transplantation].
Zhonghua Nei Ke Za Zhi
November 2023
Department of Hematology, the First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Article Synopsis
- The study investigated sex hormone levels and fertility in female patients post-hematopoietic stem cell transplantation (HSCT), focusing on correlations with conditioning regimens and the impact of hormone replacement therapy (HRT).
- A total of 147 women, with a median age of 26, were analyzed over a median follow-up of 50 months after undergoing HSCT at Soochow University, revealing a high incidence of premature ovarian failure.
- Results indicated that those undergoing myeloablative conditioning had significantly higher follicle-stimulating hormone levels compared to those on reduced-dose conditioning, and some patients experienced spontaneous menstruation and natural conception post-treatment.
Prevalence of premature ovarian insufficiency (POI) and its relationship with female reproductive factors in Iranian women: a cross-sectional study from the Persian (Shahedieh) cohort data.
BMC Womens Health
September 2023
Department of Health Education and Health Promotion, Social Determinants of Health Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Article Synopsis
- Premature ovarian insufficiency (POI) occurs when women stop menstruating and experiencing ovarian function before age 40, leading to various health complications.
- A study analyzing a cohort of 1,276 women who naturally reached menopause found that the prevalence of POI was 3% and identified factors like the number of live births and breastfeeding duration as influencing factors.
- Specifically, having more than four children reduced the likelihood of POI, and longer breastfeeding duration was linked to a lower risk of developing this condition.
Characteristics of retinal image associated with premature ovarian insufficiency: a case- control study.
J Ovarian Res
July 2023
Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, China.
Article Synopsis
- - The study aimed to create an early clinical diagnosis model for Primary Ovarian Insufficiency (POI) using retinal vascular features, providing a non-invasive method for risk prediction.
- - Researchers analyzed retinal characteristics in 78 women with spontaneous POI and 48 healthy women, finding significant differences in various retinal measurements between the two groups.
- - The results indicated that specific retinal characteristics could effectively identify POI, with a strong predictive value demonstrated by a high area under the ROC curve (0.8582), supporting the use of retinal analysis for early diagnosis of POI.
Impact of Indication for Oocyte and Embryo Reception on Reproductive and Obstetric Outcomes.
Gynecol Obstet Invest
November 2023
Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
Article Synopsis
- - This study investigated whether the reasons for oocyte reception (OR) or embryo reception (ER) affect reproductive and obstetric outcomes at a tertiary fertility center, reviewing 584 cycles from 194 patients and analyzing 27 relevant studies from various databases.
- - The major reasons for OR/ER were categorized into three groups: failure of autologous assisted reproductive technology, premature ovarian insufficiency (POI), and genetic disease carrier status.
- - Results showed no significant differences in pregnancy rates, miscarriage rates, and obstetric outcomes among the groups, consistent with existing literature, although some studies noted poorer outcomes for patients with POI from chemotherapy or radiation treatment.
Ovarian Function and Spontaneous Pregnancy After Hematopoietic Stem Cell Transplantation for Leukemia Before Puberty: An L.E.A. Cohort Study.
Transplant Cell Ther
June 2023
Department of Pediatric Hematology, Immunology and Oncology, APHM, La Timone Children's Hospital, Marseille, France; CEReS Research Unit EA 3279 and Department of Public Health, Hôpital de la Timone, Marseille, France.
Article Synopsis
Premature ovarian insufficiency and infertility.
Aust J Gen Pract
February 2023
BMBS, FRACGP, General Practitioner, General Practice Plus, South Hobart, Tas; Clinical Senior Lecturer, University of Tasmania, Hobart, Tas; President, Australasian Menopause Society, Healesville, Vic.
Article Synopsis
Family building after diagnosis of premature ovarian insufficiency: a cross-sectional survey in 324 women.
Eur J Endocrinol
March 2023
Pitié Salpêtrière Hospital, Sorbonne Université Médecine, Department of Endocrinology and Reproductive Medicine, 75651 Paris cedex 13, France.
Article Synopsis
Frequency and type of premature or early menopause in a geographically defined American population.
Maturitas
April 2023
Women's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address:
Article Synopsis
- The study aimed to determine the prevalence of premature (under 40) and early (ages 40-44) menopause in a specific U.S. population, focusing on women living in Olmsted County, MN between 1988 and 2007.
- Researchers analyzed a sample of women aged 18 to 50, finding that 3.1% experienced premature menopause and 6.2% experienced early menopause when including all causes; spontaneous menopause rates were much lower.
- The main contributor to premature menopause was the surgical removal of ovaries (bilateral oophorectomy), indicating that a significant number of women face menopause earlier than the typical age.
Spontaneous reports of primary ovarian insufficiency after vaccination: A review of the vaccine adverse event reporting system (VAERS).
Vaccine
February 2023
Immunization Safety Office, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Article Synopsis
Intraovarian Administration of Autologous Menstrual Blood Derived-Mesenchymal Stromal Cells in Women with Premature Ovarian Failure.
Arch Med Res
February 2023
Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Article Synopsis
Loss of muscle mass in women with premature ovarian insufficiency as compared with healthy controls.
Menopause
February 2023
From the Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
The hypergonadotropic hypogonadism conundrum of classic galactosemia.
Hum Reprod Update
March 2023
Division of Genetics & Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
Impact of hormone therapy on the bone density of women with premature ovarian insufficiency: A systematic review.
Maturitas
January 2023
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, Room 10166, Cerqueira Cesar, Sao Paulo, SP 05403-000, Brazil. Electronic address:
Article Synopsis
- * A systematic review of 16 studies found that women with POI generally have lower bone density compared to healthy peers, and while estrogen + progestin therapy can help stabilize bone mass, it may not reverse existing loss.
- * Higher doses of estrogen and continuous use of combined oral contraceptives appear to improve bone mineral density, but more research is needed to determine the best dosing and long-term effects of HT on bone health in women with POI.
Potential Therapeutic Effects of Human Amniotic Epithelial Cells on Gynecological Disorders Leading to Infertility or Abortion.
Stem Cell Rev Rep
February 2023
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- Successful pregnancies depend on feto-maternal tolerance, fetal non-immunogenicity, and the regulation of the mother's immune system.
- Human amniotic epithelial cells (hAECs) possess stem/progenitor characteristics and have become a focus for their potential therapeutic applications in various medical conditions.
- The review highlights hAECs’ immunomodulatory properties and their role in addressing issues like infertility, miscarriage, and implantation failure by influencing maternal immune responses.