11,170 results match your criteria: "Spleen Trauma"

Traumatic pancreatic injuries and treatment outcomes: An observational retrospective study from a high-volume tertiary trauma center.

Am J Surg

December 2024

Division of Acute Care and Trauma Surgery, Department of Surgery, Kern Medical Center, 1700 Mount Vernon Ave, Bakersfield, CA, 93306, USA. Electronic address:

Introduction: This study discusses a tertiary trauma center's experience involving traumatic pancreatic injuries, focusing on identification, management, and complications, aiming to provide a valuable contribution to the literature on pancreatic trauma management.

Methods: We conducted a five year (2019-2023) retrospective analysis utilizing trauma registry data to identified pancreatic injuries in tier 1 and 2 activations. Pancreatic Organ Injury Scaling (OIS) and overall injury severity (ISS) was assessed using AAST scoring.

View Article and Find Full Text PDF

Lack of gastric emptying at autopsy eleven days after heat trauma in the sauna- a forensic autopsy case report.

Forensic Sci Med Pathol

December 2024

Institute of Legal Medicine, University Hospital of Frankfurt, Goethe-University, Kennedyallee 104, 60596, Frankfurt/Main, Germany.

A man in his mid-70s passed out in a public 90-degree sauna and remained unconscious for at least half an hour. He suffered third-degree burns to approximately 50% of his body surface area. Despite immediate transport to a burn center and intensive care therapy, he did not regain consciousness and died eleven days later.

View Article and Find Full Text PDF

The global prevalence of obesity continues to rise. However, whether obesity affects the degree of intra-abdominal solid organ damage following blunt trauma remains unclear. This study aimed to investigate the correlation between obesity and intra-abdominal solid organ damage.

View Article and Find Full Text PDF

Background: Blunt abdominal trauma (BAT) is a significant contributor to pediatric mortality, often causing liver and spleen injuries. Contrast-enhanced computed tomography (CT), the gold standard for diagnosing solid organ injury, poses radiation risks to children. Contrast-enhanced ultrasound (CEUS) may be a promising alternative imaging modality.

View Article and Find Full Text PDF

[Management of internal bleeding : Guidelines of the American Association for the Surgery of Trauma (AAST) and World Society of Emergency Surgery (WSES)].

Radiologie (Heidelb)

December 2024

Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie und Nuklearmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Deutschland.

Background: Internal bleeding is a common and serious complication in trauma patients. The American Association for the Surgery of Trauma (AAST) and the World Society of Emergency Surgery (WSES) have developed comprehensive guidelines to standardize and optimize the care of these patients. In Germany, abdominal injuries are involved in around 20% of all polytraumas, often caused by falls or road traffic accidents.

View Article and Find Full Text PDF
Article Synopsis
  • Ionizable cationic lipids, particularly DOTAP, are used to enhance lipid nanoparticle (LNP) delivery while mitigating toxicity, showing a better T-cell response through microfluidic techniques compared to traditional methods.
  • * The study evaluated DOTAP-based delivery systems for plasmid DNA encoding the SARS-CoV-2 receptor-binding domain, finding effective delivery in muscle tissue but also significant adverse effects in multiple organs.
  • * Results indicate that while DOTAP-LNPs effectively target the lungs and spleen, they cause dose-dependent inflammatory responses and tissue injuries, highlighting the need for careful dosing in immunization strategies.
View Article and Find Full Text PDF

Background Computed tomography (CT) scans play a crucial role in emergency surgical care, serving both diagnostic and prognostic functions. They significantly contribute to timely and effective patient care. This study aims to compare abdominal CT scan reports prepared by locally employed radiologists with those from outsourced radiology reporting services for patients presenting with acute surgical conditions.

View Article and Find Full Text PDF

Lead, a heavy metal, has emerged as one of the most significant pollutants, bearing irreversible consequences on human and animal health in conjunction with industrial development. Presently, the use of medicinal plants to alleviate the adverse effects of heavy metal toxicity has captured the attention of researchers. Hence, the objective of this study was to assess the impact of levamisole and broccoli extract on the electrophoretic pattern of serum proteins, hematological parameters, and histopathological alterations in the liver, kidney, and spleen tissues within a lead poisoning model of rats.

View Article and Find Full Text PDF

The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken.

Poult Sci

November 2024

School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621000, PR China; Biomass Center, School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621000, PR China.

Intensification of poultry industry has led to a surge in animal product output, but this has also revealed issues with environmental management in poultry houses, particularly the harmful effects of high hydrogen sulfide (HS) levels on poultry health. The study aimed to assess the therapeutic impact of tea tree oil (TTO) on HS-induced spleen and intestinal injuries in chickens. A total of 240 one-day-old Lohmann Brown chicks were randomly divided into three groups: the control group (CON), the HS exposure group (AVG), and the TTO treatment group (TTG), with four replicates, each consisting of 20 chicks.

View Article and Find Full Text PDF

Background: Adult trauma centers, including combined pediatric/adult centers (CPACs), see high volumes of penetrating trauma. Few studies have compared outcomes of adolescents presenting with gunshot wounds (GSWSs) at CPACs vs. pediatric only hospitals (POHs).

View Article and Find Full Text PDF

A Rare Complication of Atraumatic Splenic Rupture in Infectious Mononucleosis: A Case Report.

Br J Hosp Med (Lond)

November 2024

Department of Surgery, General Hospital of Syros, "Vardakeio and Proïo", Hermoupolis, Syros, Greece.

Atraumatic splenic rupture is a very rare and potentially life-threatening event usually associated with underlying pathological conditions. Splenic rupture in infectious mononucleosis occurs only in 0.1%-0.

View Article and Find Full Text PDF
Article Synopsis
  • * A case study of a 54-year-old woman with chronic left upper quadrant pain led to the discovery of a 3.9 cm non-vascular splenic mass, confirmed as cystic lymphangioma through imaging and requiring laparoscopic splenectomy for symptomatic relief.
  • * Though rare in adults, splenic cystic lymphangiomas can necessitate surgery if symptomatic, with imaging being crucial for diagnosis, and laparoscopic splenectomy being the preferred treatment due to its effectiveness and safety.
View Article and Find Full Text PDF

Purpose: The "out-of-hours effect," which indicates hospital admittance during weekends or nighttime, has poorer outcomes for patients than for those admitted on weekdays and is widely documented in various medical conditions. However, this effect remains understudied in pediatric trauma cases, including blunt liver and spleen injuries (BLSIs).

Methods: This was a secondary analysis of a nationwide multicenter retrospective study, focusing on pediatric patients with trauma (≤ 16 years old) with BLSI admitted from 2008 to 2019.

View Article and Find Full Text PDF

Background: The spleen is the most commonly injured solid organ in blunt abdominal trauma, and splenic pseudoaneurysm rupture is associated with a high risk of mortality. Nonoperative management has become the standard treatment for hemodynamically stable patients with splenic injuries. On the other hand, delayed splenic pseudoaneurysms can develop in any patient, and at present, there are no known risk factors that may reliably predict their occurrence.

View Article and Find Full Text PDF

Aim: To develop a trauma surgery training program using porcine organs and evaluate its usefulness. This program allows participants to experience the tactile sensation of organs and bleeding, which are impossible in trauma surgery training using a cadaver.

Methods: Resected organs (heart, lung, liver, spleen, kidney, small intestine, bladder, and external carotid artery) from slaughtered pigs for medical research were perfused with saline solution, flash-frozen in a deep freezer, and thawed naturally on the morning of training.

View Article and Find Full Text PDF

Introduction: Alanyl-glutamine (Ala-Gln) is a compound known for its protective effects in various tissue injuries. However, its role in asthma-related lung injuries remains underexplored. This study investigates the mechanisms by which Ala-Gln modulates sDPP4-induced airway epithelial-mesenchymal transition and ovalbumin (OVA)-induced asthma in a mouse model.

View Article and Find Full Text PDF

Background: Obsidio conformable embolic (OCE, Boston Scientific, MA) is a novel, radiopaque and conformable embolic. The purpose of this report is to describe its use for treatment of acute intra-abdominal hemorrhages.

Methods And Results: Three patients presented with acute hemorrhage and were treated with OCE, including post-paracentesis hemorrhage, penetrating trauma to the liver, and blunt trauma in the spleen.

View Article and Find Full Text PDF

RSNA 2023 Abdominal Trauma AI Challenge Review and Outcomes Analysis.

Radiol Artif Intell

November 2024

From the Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, 30 Bond St, Toronto, ON, Canada, M5B 1W8 (S.H., Z.H., H.M.L., I.Y., E.C.); Edward S. Rogers Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada (Z.H., E.S.); The Jackson Laboratory, Bar Harbor, Me (R.L.B.); Department of Radiology, The Ohio State University, Columbus, Ohio (L.M.P.); Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (F.H.B.); Department of Radiology, Scripps Clinic Medical Group and University of California San Diego, San Diego, Calif (J.D.R.); Radiological Society of North America, Oak Brook, Ill (M.V.); Department of Radiology, Thomas Jefferson University, Philadelphia, Pa (A.E.F.); Department of Radiology, Weill Cornell Medicine, New York, NY (G.S.); Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Calif (J.M.), Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (B.S.M.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (M.A.D.); Duke University School of Medicine, Durham, NC (K.M.); North York General Hospital, Toronto, Ontario, Canada (E.S.); and Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada (E.C.).

Purpose To evaluate the performance of the winning machine learning (ML) models from the 2023 RSNA Abdominal Trauma Detection Artificial Intelligence Challenge. Materials and Methods The competition was hosted on Kaggle and took place between July 26, 2023, to October 15, 2023. The multicenter competition dataset consisted of 4,274 abdominal trauma CT scans in which solid organs (liver, spleen and kidneys) were annotated as healthy, low-grade or high-grade injury.

View Article and Find Full Text PDF

Ultrasound-guided removal of a splenic foreign body in a dog.

Can Vet J

November 2024

Clinique vétérinaire VetRef AniCura, 7 rue James Watt, 49070 Beaucouzé, France.

A 10-year-old spayed female bull terrier was brought to a veterinary referral center with abdominal pain. An abdominal ultrasound and CT scan identified a foreign body in the spleen. The object was removed an ultrasound-guided procedure using Hartmann foreign-body forceps, avoiding the need for laparotomy.

View Article and Find Full Text PDF
Article Synopsis
  • - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
  • - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
  • - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
View Article and Find Full Text PDF

Victims of explosive events frequently suffer from blast lung injuries. Immune system has been implicated in the pathogenesis of this disease. However, systemic immune responses underlying the progression and recovery of injury repair remain poorly understood.

View Article and Find Full Text PDF

Long-term exposure to triclocarban induces splenic injuries in mice: Insights from spatial metabolomics and lipidomics.

J Hazard Mater

December 2024

Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Triclocarban (TCC) is a widely used antimicrobial agent and known endocrine-disrupting chemical found in various products. While its potential toxicities on endocrine-related organs have been highlighted in previous studies, the effects of TCC on non-endocrine organs, particularly the spleen, remain largely unknown. Here, we employed a novel approach combining long-term TCC exposure in a mouse model with spatial metabolomics and lipidomics to investigate the effects of TCC on the spleen.

View Article and Find Full Text PDF