A case report of double etiology of ecthyma gangrenosum: Pseudomonas aeruginosa and Enterococcus faecalis in an immunocompromised child occurred during influenza evolution.

Rationale: Ecthyma gangrenosum is a cutaneous infection, most commonly occurring during sepsis evolution with Pseudomonas aeruginosa on an immunocompromised background. There have been rare case reports in previously healthy children and rarer are the cases with double etiology.

Patient Concerns: We present the case of a female Caucasian patient, aged 1 year and 8 months, who developed severe sepsis during flu evolution with predominant respiratory and cerebral manifestations.

Viridans streptococcal infective endocarditis associated with fixed orthodontic appliance managed surgically by mitral valve plasty: A case report.

Rationale: Streptococcus viridans, a heterogeneous group of alpha-hemolytic streptococci, is part of the normal flora of the mouth, usually responsible for dental caries (Streptococcus mutans, Streptococcus sanguinis), and pericoronitis, as well as for subacute infective endocarditis. They are responsible for 40-60% of the endocarditis cases occurring on the normal valves, especially in male patients and over 45 years of age. A change in the bacterial flora of the oral cavity is taking part after orthodontic fixed appliances are introduced into the oral cavity, change that is associated with an increased concentration of the acidogenic bacteria.

From a Better Understanding of the Mechanisms of Action of Histone Deacetylases Inhibitors to the Progress of the Treatment of Malignant Lymphomas and Plasma Cell Myeloma.

Background: Notable progress has been made in chemo- and immunotherapy of B-cell lymphomas, but less in the treatment of T-cell lymphomas.

Objective: Histone deacetylases inhibitors are a potentially useful therapeutic mean, as an epigenetic dysregulation is present in lymphomas, and especially in T-cell types. We aimed to study the progress made in this area.

Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report.

Rationale: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome that is characterized by an inappropriate hyperinflammatory immune response - primary, as a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or - secondary, in the progression of infections, rheumatic or autoimmune diseases, malignancies or metabolic diseases.

Patient Concerns: We present the case of a secondary HLH due to Streptococcus pneumoniae infection in a splenectomised patient for spherocytosis, a 37-year-old patient who was splenectomised in childhood for spherocytosis, without immuneprophylaxis induced by antipneumococcal vaccine.

Outcomes: He developed a severe pneumococcal sepsis associated with secondary HLH, with unfavorable outcome and death.

Raloxifene Plus Antipsychotics Versus Placebo Plus Antipsychotics in Severely Ill Decompensated Postmenopausal Women With Schizophrenia or Schizoaffective Disorder: A Randomized Controlled Trial.

Objective: Several single-center studies have found raloxifene, an estrogen agonist, to be effective in ameliorating symptoms of schizophrenia in stable patients as augmentation of antipsychotics. This multicenter study assessed whether raloxifene plus antipsychotic treatment, in comparison to placebo plus antipsychotics, improves symptoms or cognition in severely ill decompensated schizophrenia patients.

Methods: In this 16-week, double-blind, randomized, placebo-controlled study, 200 severely ill, decompensated postmenopausal women who met DSM-IV-TR criteria for schizophrenia or schizoaffective disorder were recruited from January 2011 to December 2012 and were randomized to receive either raloxifene 120 mg/d plus antipsychotics or placebo plus antipsychotics.

A rare association of chronic lymphocytic leukemia with c-ANCA-positive Wegener's granulomatosis: a case report.

Background: Wegener's granulomatosis is a systemic vasculitis of the small- and medium-sized vessels, produced by the action of ANCA, which involves the respiratory tract, kidneys, and eyes, with a potential for lethal evolution in the first year after diagnosis. Its association with chronic lymphocytic leukemia is rarely described in the literature, and it may be difficult to diagnose and to treat this association.

Case Presentation: We present the case of a 73-year-old Caucasian patient, a rare case in which Wegener's granulomatosis is associated in a patient with chronic lymphocytic leukemia, who is admitted in the Infectious Disease Department for fever, diplopia, headache, purulent and hemorrhagic nasal secretions, intense asthenia, and weight loss.

[Treating anisometric amblyopia with HTS Amblyopia iNet Software--preliminary results].

Amblyopia or "lazy eye" represents a disorder of the visual system characterized by poor vision in an eye that is otherwise physically normal. Anisometropia, the condition in which the two eyes have an unequal refractive error, is considered the second most common cause of amblyopia. The purpose of this study is to determine the efficiency of HTS Amblyopia iNet Software by studying the progress of visual acuity, contrast sensitivity and stereopsis vision in anisometropic amblyopic children.

[Role of early biliary and pancreatic decompression by minimally invasive procedure in acute pancreatitis].

Introduction: Acute pancreatitis is an acute inflammatory process of the pancreas, with variable involvement of other regional tissues or remote organ systems.

Materials And Methods: In an ongoing effort to search for optimal solution in the management of acute pancreatitis, a serious and unpredictable disease, even in the context of therapies that are part of modem therapeutic protocols line, we offer an original pathogenic and mininvasive therapeutic approach. The purpose is to bring attention to this original treatment method and highlight its advantages.

Advances in the management of malignant hemopathies: the role of statins.

Today, hematology is dependent on molecular biology for diagnosis, establishing the prognosis and treatment guidance in more and more diseases. One useful technique in this respect is the gene expression profiling, whose use is not yet a matter of routine. The discovery that the expression of LDL-receptor and cholesterol synthesis is increased in the cells of some leukemias and lymphomas and that some statins induced DNA damages and increased the level of reactive oxygen species, opens the possibility of using statins in the treatment of certain malignant hemopathies.

[The transpleurodiaphragmatic laparoscopic approach of rear dome liver cysts].

The localizations of liver cysts in the posterior hepatic dome (segment VII) and the hydatid cysts in particular, difficult to approach in "conventional" open or laparoscopic surgery, with significant parietal sacrifices and "demolition", requires a secure atypical laparoscopic approaching way, with positive results for both patient and surgeon, with minimal impact, with social and professional reintegration and faster healing. Transpleurodiaphragmatic laparoscopic approach using "Device for aspiration of liver hydatid cyst or ovarian cyst (OSIM 120809/30.04.

[Particular aspects of endoprosthesis in malignant advanced pharingeal-esophageal stenosis].

Introduction: The esophageal neoplasm is currently the seventh cause of death through cancer worlwide. In the developing countries it is situated on the fifth place and has one of the worst prognostics for a neoplasm. Due to the specifical intratoracical topography, clinically inaccesible and without symptoms, the disease is rather incurable when the disphagia appears.

[Difficult case of thoraco-abdominal injuries due to a motor vehicle accident].

Recently, in our country we experience an increase incidence of motor vehicle accidents, which often leads to some severe cases brought to the A&E's departments, requiring prompt complex surgical treatment, with the surgeon facing out of ordinary situations. This is the case for the combined trauma of the chest and abdomen. The authors present the case of a 32 years old female patient, victim of a MVA, who had suffered a deep penetrating wound of her right chest and right upper quadrant, caused by a woden pole which penetrated the anterior V and VI intercostal spaces, went through the right inferior pulmonar lobe, the diaphragm and the 7th segment of the liver, resting on the posterior wall of the ribcage.

[Multiple splenic abscesses associated with normotensive hydrocephaly].

The paper contains a concise review of the current literature on the splenic abscesses and presents an unusual association of multiple splenic abscesses with normotensive hydrocephaly to an elderly patient, treated by ventriculo-cardiac shunting and splenectomy as an one stage procedure performed by a combined surgical team (neurosurgeon, vascular surgeon and general surgeon), with a favourable outcome. As far as the authors know, this is the first communication of multiple splenic abscesses associated with adult hydrocephaly treated by a simultaneous surgical approach.

[Esophageal endoprosthesis by laparo-gastroscopy with transtumoral approach in advanced esophageal and esophagogastric cancer].

Introduction: Romania is part of the countries with low incidence of esophagus cancer (the mortality rate M/W at 100,000 peoples being 1.6/0.3), but the diagnosis of the disease, is most frequently incidental in stages that make any intention of radical treatment a desideratum frequently unattainable.

[Refractive surgery--possibilities to maximize postoperative visual acuity].

Laser refractive surgery has an ascendant evolution on the context of the progress in the medical field. The functional result can be negatively influenced by residual errors, irregular astigmatism or anisometropia, situations in which rigid gas permeable (RGP) contact lenses are a successful alternative in optimizing visual acuity. The paper presents the particularities and the protocol of RGP fitting, outlining the contribution of the corneal topography in the ocular pre and post-operative evaluation.

[Long-term prognostic value of positive peritoneal washing in colon cancer].

Unlabelled: We examined the prognostic value of free malignant cells in the peritoneal cavity of patients with colon adenocarcinoma. In 1996-1999, 88 patients underwent peritoneal washing with cytologic analysis immediately before elective colon resection for adenocarcinoma with no evidence of peritoneal metastases. Peritoneal washing fluid was collected before abdominal exploration centrifuged immediately and stained with the May-Grünwald-Giemsa and Harris-Shorr methods.

[Lagophthalmy of VII nerve palsy--therapeutical approaches].

Facial nerve palsy is impairing orbicular muscle function leading to lagophthalmos. This disease impairs patients' quality of life by exposure keratopathy which is accompanied by ocular pain and deteriorate visual acuity at a variable degree. The paper's aim is to show up the place of lagophthalmos in anterior ocular segment pathology and to evidence the results obtained by us with a new therapeutical method applied in several cases.

[Anterior uveitis in seronegative spondylarthropathies].

Purpose: To study the implication of seronegatives spondylarthropaties in anterior uveitis ethiology. We analyzed 51 patients with rheumatologic disease related uveitis hospitalized in our clinic in last 4 years. We discussed sex and age group repartition of patients, type of rheumatologic disease, recurrencies, complications and patients evolutions under treatment.

[The anatomico-radio-clinical forms of onset in pulmonary tuberculosis].

The aim of the study was to analyze the frequency of various radio-clinical forms of onset in newly discovered TB cases, in the area of the Sibiu dispensary on a period of 3 years (1992-1994). In the 327 cases included in the study, there was an equal sex ratio, with a symptomatic period of at least 3 months before the diagnosis. There was an increased percentage of unilateral cavitary forms, with an equal distribution in city and rural area.

[The variations of intraocular pressure in postpseudophakic implant].

The study represents a statistical analysis effected at a group of hundred patients from a total number of three hundred and thirty-three patients operated at Ophthalmological Clinic of Military Hospital from Sibiu with pseudophakic implant. The crystalline lens were implanted in anterior chamber as well posterior chamber. In 89 per cent was not established an increase of ocular pressure.

[The exfoliative syndrome. The risk factor in extracapsular surgery of the crystalline lens].

The exfoliative syndrome is a risk factor of the extracapsular surgery of the crystalline. Thus, on a lot of 868 operated eyes for cataract through EEC +/- IOL, 10 were founded presenting the exfoliative syndrome (1,15%). On these cases it was possible to mark the increased incidence of the intra- and postoperative complications, such as the insufficient dilatation of the pupil, the tearing of the posterior capsule, the loss of the vitreous, the modifications of the corneal endothelium, the increasing of the postoperative intraocular pressure, as well as the more frequent opacification of the posterior capsule.

[Pulmonary hamartomas--apropos 3 clinical cases].

The study starts with presentation of present day knowledge of the disease. Its features are predominantly X-ray images consisting mainly in a round or ovular, usually solitary formation ("coin lesion"). The clinical expression of the disease is usually very discrete, the general state unmodified.