11,631 results match your criteria: "Spinal Muscular Atrophy"
Front Neurol
October 2024
Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, China.
[This corrects the article DOI: 10.3389/fneur.2024.
View Article and Find Full Text PDFCan J Neurol Sci
November 2024
Division of Neurology, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
BMC Med Genomics
November 2024
Institute for Animal Genomics, University of Veterinary Medicine, Foundation, Buenteweg 17P, Hannover, D-30539, Germany.
Neuroimaging Clin N Am
February 2025
Department of Radiology, Section of Vascular and Interventional Radiology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address:
Following a review of spinal muscular atrophy pathogenesis and current therapeutics, a comprehensive review of transforaminal lumbar injections is provided. Patient preparation, special considerations, procedural technique, complications, and alternative approaches are discussed.
View Article and Find Full Text PDFJ Clin Med
October 2024
Facultad de Ciencias de la Salud, Centro de Investigaciones en Ciencias de la Vida, Universidad Simón Bolívar, Barranquilla, Atlántico 080003, Colombia.
J Clin Med
October 2024
Department of Child Health, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia.
: This systematic review evaluated the impact of nusinersen therapy on respiratory health and function in individuals with spinal muscular atrophy (SMA) and determined whether nusinersen improves pulmonary function, focusing on differences based on patient age and the timing of treatment initiation. : A systematic search of PubMed, Ovid Medline, ScienceDirect, and Web of Science databases was conducted up to January 2024 in accordance with the PRISMA guidelines. Thirteen studies were included, comprising clinical trials, observational studies, and case series that focused on respiratory outcomes in SMA patients treated with nusinersen.
View Article and Find Full Text PDFNeuropediatrics
November 2024
Neurología Pediátrica, Hospital Viamed Santa Angela de la Cruz and Neurolinkia, Sevilla, Spain.
EBioMedicine
December 2024
Regenerative Medicine Program, The Ottawa Hospital Research Institute, Ottawa, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada; Department of Medicine, University of Ottawa, Ottawa, Canada. Electronic address:
Background: The liver is a key metabolic organ, acting as a hub to metabolically connect various tissues. Spinal muscular atrophy (SMA) is a neuromuscular disorder whereby patients have an increased susceptibility to developing dyslipidaemia and liver steatosis. It remains unknown whether fatty liver is due to an intrinsic or extrinsic impact of survival motor neuron (SMN) protein depletion.
View Article and Find Full Text PDFBiometrics
October 2024
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
We consider the challenges associated with causal inference in settings where data from a randomized trial are augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE). This question is motivated by the SUNFISH trial, which investigated the effect of risdiplam on motor function in patients with spinal muscular atrophy. While the original analysis used only data generated by the trial, we explore an alternative analysis incorporating external controls from the placebo arm of a historical trial.
View Article and Find Full Text PDFNeuroradiology
December 2024
Department of Neurology, Medical University of Warsaw, ERN EURO NMD, Banacha 1a, Warsaw, 02-097, Poland.
Purpose: Some patients with spinal muscular atrophy and scoliosis require CT guidance during injections of nusinersen. The radiation applied to the operator in such procedures becomes an important issue in terms of staff health and safety. The aim of the study was to assess the operator's radiation exposure during CT-guided nusinersen injections in patients with spinal muscular atrophy and scoliosis.
View Article and Find Full Text PDFCell Mol Neurobiol
November 2024
CureScience, 5820 Oberlin Dr, Suite 202, San Diego, CA, 92121, USA.
Spinal muscular atrophy (SMA) is an autosomal recessive genetic neuromuscular disorder that is characterized by gradual muscle weakness and atrophy due to the degeneration of alpha motor neurons that are present on the anterior horn of the spinal cord. Despite the comprehensive investigations conducted by global scientists, effective treatments or interventions remain elusive. The time- and resource-intensive nature of the initial stages of drug research underscores the need for alternate strategies like drug repurposing.
View Article and Find Full Text PDFCurr Opin Pediatr
December 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore.
Purpose Of Review: The aim of the review was to provide an overview of safety and efficacy of the available treatments including information from both clinical trials and real-world data. Additional information form ongoing studies using other approaches than increasing SMN protein are also reported.
Recent Findings: In the last 3 years, there have been over 24 studies reporting safety and the impact of the available drugs on different aspects of function, including respiratory and bulbar function.
BMC Med Genomics
November 2024
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Background: The copy number status (CNS) of the survival motor neuron (SMN) gene may influence the risk and prognosis of amyotrophic lateral sclerosis (ALS) and lower motor neuron diseases (LMND) other than spinal muscular atrophy (SMA). However, previous studies of this association, mainly from Europe, have yielded controversial results, suggesting possible regional differences. Here, we investigated the effect of the SMN gene in Japanese patients with ALS and LMND.
View Article and Find Full Text PDFHum Mol Genet
November 2024
Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
Spinal muscular atrophy (SMA) is characterized by low levels of the ubiquitously expressed Survival Motor Neuron (SMN) protein, leading to progressive muscle weakness and atrophy. Skeletal muscle satellite cells play a crucial role in muscle fiber maintenance, repair, and remodelling. While the effects of SMN depletion in muscle are well documented, its precise role in satellite cell function remains largely unclear.
View Article and Find Full Text PDFArq Neuropsiquiatr
November 2024
Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Pediatria, Rio de Janeiro RJ, Brazil.
Lancet Reg Health Eur
December 2024
MDUK Oxford Neuromuscular Centre, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Center, Oxford OX3 9DU, United Kingdom.
World J Pediatr
December 2024
Department of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Am J Med Genet A
November 2024
Tianjin Children's Hospital, Children's Hospital of Tianjin University, Tianjin, China.
J Child Orthop
October 2024
Department of Orthopaedics, Nemours Children's Health, Wilmington, DE, United States.
Introduction: The neck-shaft angle and head-shaft angle in children with varying levels of neurological disability were evaluated to define change over different ages.
Methods: Children aged 1-12 years with spastic cerebral palsy, spinal muscular atrophy types 1 and 2, or typical development were reviewed to evaluate the neck-shaft angle and head-shaft angle. Patients were divided into five groups: Gross Motor Function Classification System levels I and II, Gross Motor Function Classification System level III, Gross Motor Function Classification System levels IV and V, spinal muscular atrophy types 1 and 2, and typical development.
Front RNA Res
September 2024
Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, United States.
Introduction: Molecular chaperones and co-chaperones are highly conserved cellular components that perform a variety of duties related to the proper three-dimensional folding of the proteome. The web of factors that carries out this essential task is called the proteostasis network (PN). Ribonucleoproteins (RNPs) represent an underexplored area in terms of the connections they make with the PN.
View Article and Find Full Text PDFCroat Med J
October 2024
Andrej Belančić, Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Rijeka, Croatia,
Rev Neurol (Paris)
October 2023
Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan; Institute of Medical Genomics, International University of Health and Welfare, Chiba, Japan.
bioRxiv
October 2024
Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, 80145, Naples, Italy.
Clin Sci (Lond)
November 2024
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Neurodegenerative diseases (NDs) involve the progressive loss of neuronal structure or function in the brain and spinal cord. Despite their diverse etiologies, NDs manifest similar pathologies. Emerging research identifies vascular defects as a previously neglected hallmark of NDs.
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