34,869 results match your criteria: "Spasticity"

Corticospinal and Clinical Effects of Muscle Tendon Vibration in Neurologically Impaired Individuals. A Scoping Review.

J Mot Behav

December 2024

Laboratoire de recherche Biomécanique & Neurophysiologique en Réadaptation neuro-musculo-squelettique, Centre intersectoriel en santé durable, Université du Québec à Chicoutimi, Chicoutimi, Canada.

This review verified the extent, variety, quality and main findings of studies that have tested the neurophysiological and clinical effects of muscle tendon vibration (VIB) in individuals with sensorimotor impairments. The search was conducted on PubMed, CINAHL, and SportDiscuss up to April 2024. Studies were selected if they included humans with neurological impairments, applied VIB and used at least one measure of corticospinal excitability using transcranial magnetic stimulation (TMS).

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The Chromodomain Helicase DNA-binding (CHD) protein family is ATP-dependent chromatin remodeling proteins that utilize energy produced by ATP hydrolysis to regulate chromatin structure and thereby modulate gene expression. The earliest report of a CHD3 gene mutation was by O'Roak, who found it during whole exome sequencing of 189 autism families in 2012. In 2018, Snijders Blok systematically assessed the autosomal dominant neurodevelopmental disorder caused by CHD3 gene damage, known as Snijders Blok-Campeau syndrome (SNIBCPS, OMIM 618205).

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Mutations in the skeletal isoform of the ryanodine receptor 1 (RyR1) pose grave risks during anesthesia or treatment with succinylcholine muscle relaxants. These can trigger a potentially lethal malignant hyperthermia (MH) episode via intracellular calcium increase mainly from RyR1 channel leakage. Dantrolene is the only known treatment option to prevent death.

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Enhanced gait tracking measures for individuals with stroke using leg-worn inertial sensors.

J Neuroeng Rehabil

December 2024

Max Nader Lab for Rehabilitation Technologies and Outcomes Research, Shirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.

Background: Clinical gait analysis plays a pivotal role in diagnosing and treating walking impairments. Inertial measurement units (IMUs) offer a low-cost, portable, and practical alternative to traditional gait analysis equipment, making these techniques more accessible beyond specialized clinics. Previous work and algorithms developed for specific clinical populations, like in individuals with Parkinson's disease, often do not translate effectively to other groups, such as stroke survivors, who exhibit significant variability in their gait patterns.

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Background: This research aims to improve the control of assistive devices for individuals with hemiparesis after stroke by providing intuitive and proportional motor control. Stroke is the leading cause of disability in the United States, with 80% of stroke-related disability coming in the form of hemiparesis, presented as weakness or paresis on half of the body. Current assistive exoskeletonscontrolled via electromyography do not allow for fine force regulation.

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Deep dry needling (DDN) is a method to treat muscle trigger points (TrPs) often found in persons with neuromuscular pain and spasticity. Currently, its neurophysiological actions are not well established. Thus, to understand how DDN affects spinal cord physiology, we investigated the effects of TrP DDN on spinal reflexes.

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Hereditary spastic paraplegias: When to expect bladder dysfunction a genetic and urodynamic study.

Eur J Neurol

January 2025

Sorbonne Université, Paris Brain Institute (ICM Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (APHP), University Hospital Pitié-Salpêtrière, Paris, France.

Background: The aim of this study was to characterize hereditary spastic paraplegias (HSP) patients' urodynamic profiles and development of bladder symptoms.

Methods: This is a multicentric retrospective study which included patients presenting with bladder disorders. We reviewed medical and urodynamic records in individuals with HSP and recorded age at onset of gait and bladder disorders, disability stage at the time of urodynamic assessment.

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Background & Objective: Spastic Cerebral Palsy (CP) is a neurological disorder from non-progressive brain injury or malformation during development, severely impairing movement, coordination, reflexes, posture, balance, and motor skills. Individuals with spastic CP experience limb spasticity, complicating tasks like precise gripping, particularly with toothbrushes. This study proposed a novel "all-in-one glove" for oral hygiene, assessing its efficacy and comparing it to conventional toothbrushes for spastic CP patients.

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Background: The prefrontal cortex (PFC) is an important node for action planning in the frontoparietal reaching network but its role in reaching in children with cerebral palsy (CP) is unexplored. This case-control study combines a robotic task with functional near-infrared spectroscopy (fNIRS) to concurrently assess reaching accuracy and PFC activity during time-constrained, goal-directed reaching in children with CP. We hypothesized that reaching accuracy in children with CP would be lower than in typically developing children and would be related to PFC activity.

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Objectives: To investigate the acute (directly post-stretching) and long-term (≥1 week of treatment) effects of stretching type, duration, and intensity on joint range of motion (ROM) and stiffness in ankle contractures.

Data Sources: PubMed, Embase.com, Clarivate Analytics/Web of Science Core Collection, EBSCO/SPORTDiscus, and EBSCO/CINAHL were searched for studies published in English from inception until September 12, 2023.

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The effect of foot deformities on the interplay of forces within the foot: An analysis of multi-segment foot joint moments in cerebral palsy.

Gait Posture

December 2024

Amsterdam UMC location Vrije Universiteit Amsterdam, Rehabilitation Medicine, De Boelelaan 1117, Amsterdam, The Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, The Netherlands; Amsterdam UMC location University of Amsterdam, Rehabilitation Medicine, Meibergdreef 9, Amsterdam, The Netherlands.

Background: Foot deformities are common in cerebral palsy (CP) and are likely caused by a disturbed interplay of forces in the foot. Evaluation of foot joint moments would therefore be highly relevant. However, kinetic foot models have not previously been applied to children with CP.

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Objective: This study aims to explore the research landscape, hot topics, and future trends of non-pharmacological therapies for post-stroke spastic paralysis globally from 2000 to 2024 through a bibliometric analysis.

Methods: We conducted a search in the Web of Science Core Collection database to analyze literature related to non-pharmacological therapies for post-stroke spastic paralysis published between 2000 and 2024. Tools including CiteSpace, VOSviewer, Bibliometrix, Scimago, and R language were used to identify and analyze countries, institutions, journals, references, keywords, as well as the most commonly used therapies and acupuncture points.

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A strong correlation exists between the severity of motor impairment and cognitive impairment in people with cerebral palsy. Moreover, severe cognitive impairment is associated with lower capacity for motor learning and hinders motor rehabilitation. In this report, we describe the effects of a therapeutic exercise protocol with exergames (TEP-Exergame) on postural control and spasticity of two young adults with spastic tetraplegia and moderate to severe cognitive impairment.

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Objective: The objective was to explore the characteristics of risk factors in children with cerebral palsy (CP), focusing on the effects of single risk factors and the number of risk factors on the classification, GMFCS level, and comorbidities of children with CP.

Methods: The medical records of children with CP hospitalized from 2015 to 2023 were reviewed. The effects of nine risk factors, such as hyperbilirubinemia, asphyxia, and HIE, on the classification, GMFCS level and comorbidities of children with CP were studied.

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Skin-Friendly Large Matrix Iontronic Sensing Meta-Fabric for Spasticity Visualization and Rehabilitation Training via Piezo-Ionic Dynamics.

Nanomicro Lett

December 2024

Research Center for Intelligent and Wearable Technology, College of Textiles and Clothing, State Key Laboratory of Bio-Fibers and Eco-Textiles, Health&Protective Smart Textile Research Center of Qingdao, Qingdao University, Qingdao, 266071, People's Republic of China.

Rehabilitation training is believed to be an effectual strategy that can reduce the risk of dysfunction caused by spasticity. However, achieving visualization rehabilitation training for patients remains clinically challenging. Herein, we propose visual rehabilitation training system including iontronic meta-fabrics with skin-friendly and large matrix features, as well as high-resolution image modules for distribution of human muscle tension.

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This case report describes the clinical journey of a male patient in early childhood with developmental delay, failure to thrive, worsening right-sided head tilt torticollis and regression of motor skills with spasticity of the lower limbs. The case was complex due to the early onset and gradually worsening symptoms, including a decline in established motor milestones. Genetic testing to investigate the delayed neurodevelopment revealed a variant that did not fully explain the patient's phenotype.

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Introduction: This study investigated the effects of selective dorsal rhizotomy (SDR) on dystonia and dystonic posture in patients with cerebral palsy (CP) presenting with mixed spasticity and dystonia.

Method: A prospective, single-centre study was conducted at a UK supra-regional centre from May 2013 to September 2022. All children with spasticity, dystonia and/or dystonic posture undergoing SDR were included.

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Entropion.

Tidsskr Nor Laegeforen

December 2024

Øyeavdelingen, Drammen sykehus, Vestre Viken, og, Øyeavdelingen, Oslo universitetssykehus, og, Øyeavdelingen, Stavanger universitetssjukehus, og, Øyeavdelingen, Sørlandet sykehus, Arendal, og, Øyeavdelingen, Sykehuset i Vestfold, og, Øyeavdelingen, Sykehuset Østfold.

Entropion, or the inward turning of the eyelid, is common, particularly in older patients. The condition is classified as involutional, cicatricial, spastic or congenital. Involutional entropion is most common and typically treated with lateral tarsal strip, which may be combined with other techniques for eyelid eversion.

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Background: Human T-cell Lymphotropic Virus type-1 (HTLV-1) infection is associated with serious disorders, including Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to sexual, vertical, parenteral, and blood transfusion, organ/tissue transplantation is considered as a transmission route of HTLV infection. Given the substantial risk of HTLV-1 transmission and the subsequent development of HAM/TSP (approximately 40%) in kidney transplant recipients, pre-transplant donor screening is crucial.

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Diagnosing hereditary spastic paraplegia (HSP) in paediatric patients can be challenging, especially when there is no positive family history. Children are often initially misdiagnosed with cerebral palsy due to the gradual progression of the disease and non-specific neuroimaging findings, despite the absence of perinatal insult. This misdiagnosis can prevent timely prenatal diagnosis, limiting the ability to make informed decisions about the pregnancy and to plan early interventions.

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Simulated effects of surgical corrections on bone-implant micromotion and implant stresses in paediatric proximal femoral osteotomy.

Comput Biol Med

December 2024

Griffith Center of Biomedical and Rehabilitation Engineering (GCORE), Griffith University, Australia; School of Medicine and Dentistry, Griffith University, Australia; Department of Orthopaedics, Children's Health Queensland Hospital and Health Service, Australia. Electronic address:

Background And Objective: Proximal femoral osteotomy (PFO) is a surgical intervention, typically performed on paediatric population, that aims to correct femoral deformities caused by different pathologies (e.g., slipped capital femoral epiphysis).

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Introduction: Post-stroke spasticity (PSS) occurs in ~25-43% of patients between 2 weeks and 3 months following a stroke. This retrospective claims study examined the occurrence of spasticity, treatment patterns, healthcare resource utilization, and healthcare costs among patients who experienced a stroke over a 2-year period.

Methods: Analyses were conducted using healthcare claims from the IQVIA PharMetrics Plus database of commercially/self-insured members from 2015 to 2021.

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Aim: This study aimed to compare gross motor function between aquatic- and land-based exercises in children and adolescents with cerebral palsy (CP).

Methods: The authors conducted an electronic search of nine databases from their inception to 21 November 2024 (PROSPERO registration: CRD42020194121). Inclusion criteria were randomized controlled trials involving aquatic-based exercises for children and adolescents with CP, assessing gross motor function using standardized scales or tests.

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Background: Multiple sclerosis (MS) encompasses various symptoms, including fatigue, pain, spasticity, motor dysfunction, postural instability, sexual and bladder dysfunction, and cognitive impairment. Despite the documented benefits of exercise for alleviating MS symptoms, adherence to physical activity guidelines often is low, resulting in sedentary lifestyles among people with MS. This qualitative study explores the experiences of individuals with MS who participated in a ballroom dance intervention.

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Current and Potential Use of Biologically Active Compounds Derived from L. in the Treatment of Selected Diseases.

Int J Mol Sci

November 2024

Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Street141/143, 90-236 Lodz, Poland.

L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids and the cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoids have an effect on the endocannabinoid system (ECS), a cellular communication network, and are, hence, widely studied for medical applications.

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