3 results match your criteria: "Spanish National Research Council (CSIC)-Autonomous University of Madrid (UAM) and IdiPAZ[Affiliation]"
; a healthy lifestyle app for new US firefighters: usability and pilot study protocol.
Front Endocrinol (Lausanne)
November 2023
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
In the United States (US), new firefighters' fitness and health behaviors deteriorate rapidly after fire academy graduation. Over the long-term, this increases their risks for chronic diseases. This study protocol describes the proposed usability testing and pilot study of a newly designed and developed healthy lifestyle smartphone app, "Surviving & Thriving", tailored towards young US firefighters.
View Article and Find Full Text PDFp53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.
Nat Commun
May 2022
Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC, Hospital del Mar, Barcelona, 08003, Spain.
Article Synopsis
- - Current colorectal cancer (CRC) treatments often focus on DNA-damaging agents, but they don't work for all patients, and their effects on tumor behavior are not well understood.
- - Research using patient-derived organoids reveals that sublethal chemotherapy doses can make TP53 wildtype cancer cells enter a quiescent state, adopting a fetal-like phenotype that boosts their tumor-initiating and metastatic abilities.
- - The presence of this fetal phenotype and nuclear YAP1 in tumors at diagnosis is linked to poor patient outcomes, suggesting that combining chemotherapy with YAP1 inhibitors may improve treatment efficacy for resistant TP53 wildtype CRC cells.
Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.
FEBS J
January 2020
Departments of Cancer Biology and Biochemistry, Instituto de Investigaciones Biomédicas 'Alberto Sols', Spanish National Research Council (CSIC)-Autonomous University of Madrid (UAM) and IdiPAZ, Madrid, Spain.
Intestine is a major target of vitamin D and several studies indicate an association between vitamin D deficiency and inflammatory bowel diseases (IBD), but also increased colorectal cancer (CRC) risk and mortality. However, the putative effects of 1α,25-dihydroxyvitamin D (calcitriol), the active vitamin D metabolite, on human colonic stem cells are unknown. Here we show by immunohistochemistry and RNAscope in situ hybridization that vitamin D receptor (VDR) is unexpectedly expressed in LGR5 colon stem cells in human tissue and in normal and tumor organoid cultures generated from patient biopsies.
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