2 results match your criteria: "Spain. Electronic address: jpineda.hmcinac@hmhospitales.com.[Affiliation]"
The road ahead to successful BBB opening and drug-delivery with focused ultrasound.
J Control Release
August 2024
HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Spain. Electronic address:
This review delves into the innovative technology of Blood-Brain Barrier (BBB) opening with low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising therapeutic modality aimed at enhancing drug delivery to the central nervous system (CNS). The BBB's selective permeability, while crucial for neuroprotection, significantly hampers the efficacy of pharmacological treatments for CNS disorders. LIFU-MB emerges as a non-invasive and localized method to transiently increase BBB permeability, facilitating the delivery of therapeutic molecules.
View Article and Find Full Text PDFLesion 3D modeling in transcranial MR-guided focused ultrasound thalamotomy.
Magn Reson Imaging
July 2021
HM CINAC, Centro Integral de Neurociencias AC, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain; Universidad San Pablo CEU, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas Instituto Carlos III, Madrid, Spain. Electronic address:
Transcranial magnetic resonance-guided focused ultrasound (tMRgFUS) allows to perform incisionless thermoablation of deep brain structures. This feature makes it a very useful tool for the treatment of multiple neurological and psychiatric disorders. Currently, feedback of the thermoablation process is based on peak temperature readings assessed on real-time two-dimensional MRI thermometry.
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