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Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury.
Invest Ophthalmol Vis Sci
March 2016
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain, and Fundación para la Investigación-HCSC, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain 3Instituto Universitario.
Article Synopsis
- The study aimed to evaluate how ketorolac, a nonsteroidal anti-inflammatory drug, impacts the survival of retinal ganglion cells after optic nerve injury.
- Ketorolac was tested in two forms: a solution injected before or during nerve damage and from biodegradable microspheres, with both forms showing varying degrees of effectiveness in preserving cell survival.
- Results indicated that pre-treatment with ketorolac solution yielded the highest survival rates of retinal ganglion cells, suggesting that timely administration may play a crucial role in protecting against cell death post-injury.