Systematics of the complex, with evidence for 3 additional Afrotropical bat species.

Roughly a third of all horseshoe bat species (Rhinolophidae: ) are found in Africa, where a recent continent-wide genetic survey suggested the presence of both undescribed and apparently invalid species. Here, we focus on the species complex and the recent elevation of Peters, 1852, to species rank. That action created ambiguity in the taxonomy of East African members of the group-are both Martin, 1838, and sympatric in East Africa or is another, unnamed species present there? Here, we refine genetic, morphological, and behavioral characterizations of and its erstwhile synonyms with samples from the vicinity of their type localities.

First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours.

Objective: The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.

Methods And Analysis: In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion was conducted in tumour-type cohorts (with or without prior anti-PD-1/PD-L1 (programmed death protein 1/programmed death ligand 1) therapy).

Interest, uptake, and feasibility trial of a real-life digital health intervention to improve lifestyle in Brazil.

Objective: Promoting healthy lifestyle behaviors is essential for preventing and managing chronic and mental health conditions. This study aims to present a digital health platform accessible via PC or smartphone, , designed to foster lifestyle change among the Brazilian population. It evaluates interest, uptake, acceptability, usability, adherence, and retention over 12 weeks.

Understanding the Ligand Influence in the Multistep Reaction of Diazoalkanes with Palladium Complexes Leading to Carbene-Aryl Coupling.

The reaction of diphosphino aryl complexes [Pd(CF)(L-L)(NCMe)](BF) (L-L = dppe, dppp, dppb) with diazoalkanes NCHR ( = -CH=CHPh, Ph) leads to η-allyl or η-benzyl palladium derivatives that are the organometallic products resulting from carbene-aryl coupling. The experimental trend shows that the reaction is favored for dppe > dppp > dppb. It involves several consecutive steps, i.

Evaluation of the efficacy of Capacitive Resistive Monopolar Radiofrequency at 448 kHz in the physiotherapeutic treatment of female dyspareunia.

Background And Purpose: Dyspareunia is genital pain associated with sexual activity that affects the quality of life of many women. Physiotherapy is a promising, albeit sometimes uncomfortable, option. This study aims to integrate capacitive resistive monopolar radiofrequency (CRMRF) as a complementary therapy.

Beyond support: exploring the dynamic and static biomechanical changes induced by preventive ankle taping: a novel cross-sectional study.

Introduction: In sports, 80% of all ankle injuries are sprains of the external compartment. Functional bandages are usually used preventively, specially in individuals with a history of lateral ankle injuries. To this day, the actual benefits of such taping remain unknown as important modifications are introduced in the ankle biomechanics.

First record of Serban, 2000 (Bathynellacea, Bathynellidae) from subterranean waters of South Korea, with the description of a new species.

This study describes , the first new species of Bathynellidae family reported in East Asia since 2000, and it presents the first molecular analysis using CO1 and 18S gene sequences. Morphological analysis reveals that the new species and previously known species uniquely share key characteristics in the male and female thoracopods VIII. However, the presence or absence of the median seta on the antenna exopod, along with the length differences between the four spines in the furca, distinguish the new species from , 2000.

The impact of interfacial quality and nanoscale performance disorder on the stability of alloyed perovskite solar cells.

Microscopy provides a proxy for assessing the operation of perovskite solar cells, yet most works in the literature have focused on bare perovskite thin films, missing charge transport and recombination losses present in full devices. Here we demonstrate a multimodal operando microscopy toolkit to measure and spatially correlate nanoscale charge transport losses, recombination losses and chemical composition. By applying this toolkit to the same scan areas of state-of-the-art, alloyed perovskite cells before and after extended operation, we show that devices with the highest macroscopic performance have the lowest initial performance spatial heterogeneity-a crucial link that is missed in conventional microscopy.

Chemoenzymatic synthesis of Tamsulosin.

Several chemoenzymatic pathways have been developed for the stereoselective production of the drug tamsulosin. The interest in the exclusive synthesis of its ()-enantiomer lies in the greater activity compared to that displayed by its ()-counterpart for the treatment of kidney stones and benign prostatic hyperplasia disease. Using different types of biocatalysts such as lipases, alcohol dehydrogenases and transaminases, three complementary strategies have been studied to introduce chirality into a key synthetic precursor.

Structure-activity relationship of peptide conjugates derived from BP100 and insights into their interactions with lipid membranes by NMR and MD simulations.

Antimicrobial and plant defence elicitor peptides have received attention on last decades as novel tools to combat bacterial plant diseases. We previously reported a library of peptide conjugates resulting from the combination of an antimicrobial peptide (, , or ) and a plant defence elicitor sequence (, , or ). From this library, we selected a set of 14 peptide conjugates including both highly and poorly active sequences and we performed a structure-activity relationship study by NMR and MD simulations.

Paper and Pencil Design of Color-Pure Organic Emitters: The Curious Case of Xanthene Dyes.

The quest for color-pure emitters for multicolor bioimaging as well as for ultrahigh definition organic light-emitting diodes demands facile design concepts to avoid tedious synthetic or computational trial-and-error procedures. We have recently presented a simple recipe to construct color-pure blue emitters, which combines basic resonance structure and frontier molecular orbital treatments; this recipe applies to multiresonant type emitters and allows to enlarge the chemical space toward novel structural motifs. In the current work, we show that such fundamental considerations further apply to the structurally entirely different family of xanthene dyes.

An overloaded pure silica zeolite ISV synthesized using a phosphonium cation.

A pure silica zeolite with structure was synthesized using the tricyclopentylmethylphosphonium (CpMP) cation under fluoride media. Analysis of the organic content in the zeolite suggested the presence of more than four cations per unit cell, while fluoride anions were exclusively located in the four double four-membered rings of the structure. Si solid-state NMR demonstrated a significant concentration of Si species, , S̲i̲(OSi)(OH), in the structure, which afforded charge balance but contrasted with the most common observation of defect-free pure silica zeolites prepared in fluoride media at near-neutral pH.

Versatile methodology for the synthesis of stable magnetic SERS-encoded clusters for sensing applications.

Surface-enhanced Raman scattering (SERS) substrates are garnering increasing interest for ultrasensitive high-throughput sensing. Notably, SERS-encoded nanostructures stand out due to their potential for nearly unlimited codification with excellent optical properties. In this paper we report a simple, versatile and cost-effective method for preparing SERS-encoded clusters.

Diverse and Selective Metal-Ligand Cooperative Routes for Activating Non-Functionalized Ketones.

The rhodium and iridium complexes [Cp*M(κ,,-)][SbF] (Cp* = η-CMe; M = Rh, ; Ir, ; = pyridinyl-amidine ligand) exhibit three different cooperative metal-ligand reactivity modes when interacting with nonfunctionalized ketones. With the methyl ketones CHCOR (R = CH, Ph, CF), activation of the ketone methyl C(sp)-H bond yields ketonyl compounds of formula [Cp*M(CHCOR)(κ,-)][SbF]. With the ketones (CF)CO and CFCOPh, the complexes add to the C═O double bond of the ketone.

Adeno-associated viral vectors for modeling Parkinson's disease in non-human primates.

The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor, but extremely challenging. Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials. While these failures have many possible explanations, it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.

Growing Hybrid Cuticles: Metallochitins as an Emerging Family of Bioactive Mimics of Chitin.

Inspired by the properties of natural chitin, the present work provides the first solid foundation for growing conformal ultrathin antibacterial films of organic chitin through a solvent-free molecular layer deposition (MLD) process. This work establishes the initial groundwork for growing biomimetic hybrid cuticles by combining sugar-type molecules with vapor-phase metal-organic precursors, which we term metallochitins or, more generally, metallosaccharides. The MLD process, featuring mild temperatures and solvent-free conditions, provides exceptional conformality and thickness precision, ensuring highly conformal coatings on diverse high aspect ratio substrates.

Development of machine learning-based models for vault prediction in implantable collamer lens surgery according to implant orientation.

Purpose: The main objective was to develop a prediction model based on machine learning to calculate the postoperative vault as well as the ideal implantable collamer lens (ICL) size, considering for the first time the implantation orientation in a Caucasian population.

Setting: Arruzafa Ophthalmological Hospital (Cordoba, Spain) and Barraquer Ophthalmology Center (Barcelona, Spain).

Design: Multicenter, randomized, retrospective study.

Analysis of Image-Based Sexual Harassment and Abuse in Adolescents' Socio-Affective Relationships.

The recent reconceptualization of the phenomenon of sexting between consensual and nonconsensual represents a relevant turning point in identifying and addressing nonconsensual sexting behaviors as online sexual violence. These practices of nonconsensual sexting, therefore, represent forms of technology-facilitated sexual violence, incorporating the terms image-based sexual harassment (IBSH) and image-based sexual abuse (IBSA) to describe the distribution of self-produced sexualized images in the online sphere by adolescents, who use the online environment as their main socialization space. The objective of this investigation is dual.

Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma.

Background: Transarterial chemoembolization (TACE) is the first-line therapeutic option for patients with intermediate-stage hepatocellular carcinoma (HCC). Tumor neovascularization allows tumor growth and may facilitate the release of circulating tumor cells (CTCs) to the bloodstream after TACE. We investigated the relationship between early release of CTCs and radiological response after TACE.

Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial.

Background: Although transcutaneous spinal cord stimulation (tSCS) has been suggested as a safe and feasible intervention for gait rehabilitation, no studies have determined its effectiveness compared to sham stimulation.

Objective: To determine the effectiveness of tSCS combined with robotic-assisted gait training (RAGT) on lower limb muscle strength and walking function in incomplete spinal cord injury (iSCI) participants.

Methods: A randomized, double-blind, sham-controlled clinical trial was conducted.

Implementation of the STEPPS program for the treatment of self-harm behaviors in Catalonia's prisons: barriers and facilitators.

Background: The Systems Training for Emotional Predictability and Problem Solving (STEPPS) is an evidence-based program that has been shown to be effective in reducing self-harm behaviors in Correctional Settings (CS). However, there is limited understanding of the contextual factors that impact the implementation of this intervention within such complex environments. A comprehensive understanding of the implementation process is crucial for the successful adoption of this program.

A digital intervention to reduce home-office workers' sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial.

Background: A new paradigm of hybrid working exists, with most office workers sharing their work between the office and home office environment. Working from home increases time spent or prolonged sitting, which is associated with an increased risk of chronic disease. Interventions to reduce sitting time, specifically designed for both the office and home-office environments, are required to address this growing public health issue.

Is maternal diabetes during pregnancy associated with neurodevelopmental, cognitive and behavioural outcomes in children? Insights from individual participant data meta-analysis in ten birth cohorts.

Background: Growing evidence shows that dysregulated metabolic intrauterine environments can affect offspring's neurodevelopment and behaviour. However, the results of individual cohort studies have been inconsistent. We aimed to investigate the association between maternal diabetes before pregnancy and gestational diabetes mellitus (GDM) with neurodevelopmental, cognitive and behavioural outcomes in children.

Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits.

Alzheimer's disease (AD) is characterized by memory loss and neuropsychiatric symptoms associated with cerebral amyloid-β (Aβ) and tau pathologies, but whether and how these factors differentially disrupt neural circuits remains unclear. Here, we investigated the vulnerability of memory and emotional circuits to Aβ and tau pathologies in mice expressing mutant human amyloid precursor protein (APP), Tau or both APP/Tau in excitatory neurons. APP/Tau mice develop age- and sex-dependent Aβ and phosphorylated tau pathologies, the latter exacerbated at early stages, in vulnerable brain regions.