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Spain ; Central University Hospital of ... Publications | LitMetric

757,999 results match your criteria: "Spain ; Central University Hospital of Asturias[Affiliation]"

Patient-specific implant placement in the case of pelvic tumour resection is usually a complex procedure, where the planned optimal position of the prosthesis may differ from the final location. This discrepancy arises from incorrect or differently executed bone resection and improper final positioning of the prosthesis. In order to overcome such mismatch, a navigation solution is presented based on an augmented reality application for HoloLens 2 to assist the entire procedure.

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The urge to adopt cleaner technologies drives the search for novel and sustainable materials such as Hydrophobic Natural Deep Eutectic Solvents (HNADESs), a new class of green solvents characterized by their low toxicity, biodegradability, and tunable properties, aiming to be applied in various fields for handling non-polar substances. In this work, the solubilization of hydrocarbons in type V HNADESs (non-ionic organic molecules) formed by mixing carvone, a natural monoterpenoid, with organic acids (hexanoic to decanoic acids) is examined by applying both experimental and theoretical approaches. The synthesis and physicochemical characterization of different HNADESs allowed us to tailor their properties, aiming for optimal interactions with desired hydrocarbons.

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Background And Purpose: Psoriasis is a chronic, immune-mediated inflammatory skin disease that significantly impacts patients' quality of life. The integration of telepharmacy has the potential to enhance patient care by providing flexible and personalized pharmaceutical follow-up. This study (TELEPROM Psoriasis) evaluates a telepharmacy model for evaluating electronic Patient-Reported outcomes (ePROMs) for individuals with moderate to severe plaque psoriasis in Spain with biological treatment.

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Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling.

iScience

December 2024

Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.

Autophagy-lysosomal degradation is a conserved homeostatic process considered to be crucial for cardiac morphogenesis. However, both its cell specificity and functional role during heart development remain unclear. Here, we introduced zebrafish models to visualize autophagic vesicles and track their temporal and cellular localization in the larval heart.

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The thyroid is a rare site for finding tumor metastases. Renal, colorectal, pulmonary, and mammary origin are the most frequent primary neoplasms. Clinical suspicion, early diagnosis, and active surveillance are important during follow-up.

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Jumping Dynamics of Cyanomethyl Radicals on Corrugated Graphene/Ru(0001) Substrates.

J Phys Chem C Nanomater Interfaces

December 2024

Instituto IMDEA Nanociencia, Calle Faraday 9, 28049 Madrid, Spain.

Graphene adsorbed on Ru(0001) has been widely used as a template for adsorbing and isolating molecules, assembling organic-molecule structures with desired geometric and electronic properties and even inducing chemical reactions that are challenging to achieve in the gas phase. To fully exploit the potential of this substrate, for example, by being able to tune a graphene-based catalyst to perform optimally under specific conditions, it is crucial to understand the factors and mechanisms governing the molecule-substrate interaction. To contribute to this effort, we have conducted a combined experimental and theoretical study of the adsorption of cyanomethyl radicals (-CHCN) on this substrate below room temperature by performing scanning tunneling microscopy experiments and density functional theory simulations.

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The neuraxial delivery of drugs for the management of pain and other spinal pathologies is widely employed and is the subject of a large volume of ongoing research with several thousand papers appearing in the past 5 years alone on neuraxial delivery. Several learned texts have been recently published. A number of considerations have contributed to this widespread interest in the development of the use of neuraxial therapeutics to manage pain.

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Background And Aims: The current study aimed to compare the effects of 12 weeks of moderate versus high-intensity water aerobics on muscle strength, body composition, lipid profile, blood pressure, and quality of life in both adults and older adults.

Methods: Twenty-one women (65.19 ± 9.

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Worldwide, mortality was strongly affected by the COVID-19 pandemic, both directly through COVID-19 deaths and indirectly through changes in other causes of death. Here, we examine the impact of the pandemic on COVID-19 and non-COVID-19 mortality in 24 countries: Australia, Austria, Brazil, Bulgaria, Canada, Chile, Croatia, Czechia, Denmark, England and Wales, Hungary, Japan, Latvia, Lithuania, The Netherlands, Northern Ireland, Poland, Russia, Scotland, South Korea, Spain, Sweden, Switzerland, and the United States. Using demographic decomposition methods, we compare age- and cause-specific contributions to changes in female and male life expectancy at birth in 2019-2020, 2020-2021, and 2021-2022 with those before the COVID-19 pandemic (2015-2019).

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Objective: The aim of this study was to examine the acute effects on mechanical, neuromuscular, metabolic, and muscle contractile responses to different set configurations in full-squat (SQ).

Methods: Twenty-two men performed three SQ sessions that consisted of 3 sets of 12 repetitions with 60% 1RM with 4 minutes inter-set rests: a) traditional set (TS): no rest within the set; b) cluster-6 (CS6): a 30 seconds intraset rest after the 6th repetition of each set; and c) cluster-2 (CS2): a 30 seconds intraset rest every 2 repetitions. Mechanical (i.

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Tinnitus is a heterogeneous hearing disorder with no cure at present, but some treatments, such as a combination of counselling and sound therapy, can alleviate the discomfort it causes. The sound therapy efficiency depends on both the type of sound stimulus and the time of exposure. This study describes the fundamentals of a personalized sound therapy that stimulates the auditory system with either continuous or sequential sounds whose spectra are adjusted to the hearing levels of the participants.

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Stapes surgery is the gold standard for managing otosclerosis. It has become increasingly appreciated to perform endoscopic ear surgery worldwide as the field of endoscopy expands. In basic terms, a stapes surgery intends to restore ossicular mobility and therefore improve sound energy transduction into the inner ear, thereby improving communication and sound amplification and bringing hearing levels back to acceptable levels.

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The use of a composite welded joint consisting of titanium and austenitic stainless steel metals is evidently a favourable selection for industrial applications employing the resistance spot welding (RSW) operation. Nevertheless, achieving a high-quality welded joint proved challenging owing to the properties of the diverse range of materials' used. To improve the quality of dissimilar welded joints, the welding parameters should be selected precisely.

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Clinical impact of DPYD genotyping and dose adjustment in candidates for fluoropyrimidine treatment.

Heliyon

December 2024

Instituto de Investigación Sanitaria de Canarias, Carretera Gral. La Cuesta-Taco, n.s/n Pabellón de Gobierno del HUC Planta -1ª, 38320, San Cristobal de La Laguna, Santa Cruz de, Tenerife, Spain.

Image 1.

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Purpose: The purpose of the study was to analyze patients with vaginal-involving recurrences of gynecological tumors and primary vaginal tumors, treated with transperineal interstitial brachytherapy (P-ISBT). Dosimetric, clinical, and toxicity analysis of these patients was conducted, incorporating MRI in volume definition and dose-volume dosimetry.

Material And Methods: Forty-two patients were retrospectively analyzed.

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Purpose: Currently, there are many schedules for exclusive vaginal cuff brachytherapy (VCB). In 3D treatment planning for VCB dosimetry, parameters have not been analyzed. The aim of this study was to compare the most common schedules using dose-volume histogram metrics.

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Qualitative studies on men with prostate cancer: a systematic meta-synthesis.

Int J Qual Stud Health Well-being

December 2025

Department of Anthropology, Philosophy, and Social Work, Medical Anthropology Research Center, Universitat Rovira i Virgili, Tarragona, Spain.

Purpose: Prostate cancer (PCa) is the second most common cancer among men. Despite advancements in clinical interventions and improvements in public health outreach, a multi-dimensional lack of understanding of the lived experiences of men diagnosed with PCa continues. Improving the quantity and quality of knowledge about this subject could guide clinical decisions and interventions for this group.

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Genomic evidence of GLP-1 receptor as target for the treatment of substance use disorders.

Eur Neuropsychopharmacol

December 2024

Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Galicia, Spain. Electronic address:

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Respiratory health in serious mental illness.

Eur Neuropsychopharmacol

December 2024

Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Avenida Menéndez Pidal, 14004, Córdoba, Spain; Reina Sofia University Hospital, Avenida Menéndez Pidal 7, 14004, Córdoba, Spain; University of Cordoba, Department of Morphological and Sociosanitary Science, Córdoba, Spain.

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The design of efficient bacterial inactivation treatment in wastewater is challenging due to its numerous parameters and the complex composition of wastewater. Although solar photochemical processes (PCPs) provide energy-saving benefits, a balance must be maintained between bacterial inactivation efficiency and experimental costs. Predictive decision tools for bacterial inactivation under various conditions would significantly contribute to optimizing PCP design resources.

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Synthetic data generation in healthcare: A scoping review of reviews on domains, motivations, and future applications.

Int J Med Inform

December 2024

Life Supporting Technologies Research Group, Universidad Politécnica de Madrid, Avda Complutense 30, 28040 Madrid, Spain.

Background: The development of Artificial Intelligence in the healthcare sector is generating a great impact. However, one of the primary challenges for the implementation of this technology is the access to high-quality data due to issues in data collection and regulatory constraints, for which synthetic data is an emerging alternative. While previous research has reviewed synthetic data generation techniques, there is limited focus on their applications and the motivations driving their synthesis.

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Development of a nano-specific safe-by-design module to identify risk management strategies.

Ann Work Expo Health

December 2024

TNO Research Group Risk Analysis for Prevention, Innovation and Development, Princetonlaan 6, PO Box 80015, Utrecht 3584 CB, The Netherlands.

This article describes the development of a Safe-by-Design (SbD) module and its integration into an easy-to-use tool, named the Nano Exposure Quantifier-Safe-by-Design (NEQ-SbD) tool. The NEQ-SbD tool guides its user to lower the exposure to nanomaterials at the worksite where nanomaterials are manipulated or handled during a wide range of activities. This allows the tool user with an informed decision to assess airborne exposure and to select, compare, and identify appropriate risk management measures (RMM).

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Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

J Nanobiotechnology

December 2024

Cancer Stem Cells and Fibroinflammatory Microenvironment Group, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale CSIC-UAM, 28029, Madrid, Spain.

Background: Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but also metastatic lesions are needed. Tumor-Associated Macrophages (TAMs) have emerged as central players, significantly influencing PDAC progression and metastasis.

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