A Unique Case of 'in Situ' Bifluoride Triggered Formation of Supramolecular Organogels Using Isophthalamide Hydrogen Bond Donating Receptors.

A novel isopthalamide based receptor HL2 featuring two p-benzoic acid units has been synthesised and its anion binding properties analysed by H-NMR spectroscopy in DMSO-d/0.5 % HO. As expected, in the presence of tetrabutylammonium (TBA) fluoride the deprotonation of the carboxylic acid moieties was observed.

Dual surrogate imprinting: an innovative strategy for the preparation of virus-selective particles.

This work involves the preparation of dual surrogate-imprinted polymers (D-MIPs) for the capture of SARS-CoV-2. To achieve this goal, an innovative and novel dual imprinting approach using carboxylated-polystyrene (PS-COOH) nanoparticles with a diameter of 100 nm and a SARS-CoV-2 Spike-derived peptide was carried out at the surface of amine-functionalized silica (PS-NH) microspheres with a diameter of 500 nm. Firstly, PS-COOH nanoparticles with the same size and spherical shape as the SARS-CoV-2 virus were employed to form hemispherical indentations (HI) at the surface of the PS-NH microspheres (obtaining dummy particle-imprinted polymers, HI-MIPs).

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Background And Objectives: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.

Methods: We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months.

First-in-Human Phase 1 study of a CD16A bispecific innate cell engager, AFM24, targeting EGFR-expressing solid tumors.

Purpose: Innate immune cell-based therapies have shown promising antitumor activity against solid and hematologic malignancies. AFM24, a bispecific innate cell engager, binds CD16A on natural killer (NK) cells/macrophages and EGFR on tumor cells, redirecting antitumor activity towards tumors. The safety and tolerability of AFM24 was evaluated in this Phase 1/2a dose escalation/dose expansion study in patients with recurrent or persistent, advanced solid tumors known to express EGFR.

Population pharmacokinetic analysis of teicoplanin in paediatric patients, including those receiving continuous kidney replacement therapy: a prospective cohort study.

Objectives: Teicoplanin is a commonly used antibiotic in critically ill children. However, teicoplanin dosing is often inaccurate, especially in children undergoing continuous kidney replacement therapy (CKRT). This study aims to develop a population pharmacokinetic (PK) model to optimize teicoplanin dosing in critically ill children, including those on CKRT.

Treatment of Onychomycosis and the Drug-Drug Interactions in Patients with Diabetes Mellitus and Diabetic Foot Syndrome: A Systematic Review.

This systematic review reports on treatments for onychomycosis in patients with diabetes and the drug interactions with other drugs in regard to the complicated diabetic patient profile. The recommendations in the preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist were applied and the included studies were evaluated using the Consolidated Standards of Reporting Trials (CONSORT) statement and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Searches were conducted in November 2023, using the PubMed (Medline), Scopus, Cochrane Library, and Web of Science databases; studies on antifungal treatments for onychomycosis in patients with diabetes were included.

Validity of a New Portable Sensor to Measure Velocity-Based Resistance Training.

This study evaluated the concurrent validity of the Vitruve linear encoder compared to the T-Force device for measuring mean propulsive velocity (MPV) and peak velocity (PV) during the free-weight bench press exercise. Thirteen resistance-trained men participated in three sessions, during which MPV and PV were recorded simultaneously by both devices. The data were analysed using one-way ANOVA, Pearson's correlation, Bland-Altman analysis, and effect size calculations, with statistical significance set at ≤ 0.

The Evolution of Match Running Performance in the Top Two Spanish Soccer Leagues: A Comparative Four-Season Study.

: This study uniquely examines the evolution of match running performance in official matches over four consecutive seasons (2019/2020-2022/23) within Spain's top two professional soccer leagues (LaLiga). By analyzing differences between competitive league standards (First Division vs. Second Division), this research provides critical insights into how competition levels influence physical performance trends over time.

Technical and Tactical Performance in Women's Singles Pickleball: A Notational Analysis of Key Match Indicators.

Pickleball has experienced remarkable growth in recent years, yet studies exploring its specific characteristics are scarce. This investigation provides a detailed notational analysis of women's singles pickleball, evaluating the technical and tactical performance indicators in the game. An observational methodology was used to analyze all points from five PPA Tour tournaments.

Multisport-Integrated Training for Rugby Instructors: Success and Effects on Minirugby Players.

Background/objectives: The educational system thinking approach (ST) takes a holistic vision of instructors/teachers and learners' relationships, making sports pivotal for reflection on education. This study evaluated the efficacy of a multisport ST-based course on minirugby instructors' teaching competence and children players' motor conduct.

Methods: The twenty-five rugby instructors (IAC) attended the 25 h course and the children of their teams (n = 109, Ch-IAC) participated in this study as experimental groups.

Repeatability and Validity of Different Methods to Determine the Anaerobic Threshold Through the Maximal Multistage Test in Male Cyclists and Triathletes.

: The aim of this study was to analyze the repeatability and validity of different methods to determine the anaerobic threshold through a maximal multistage cycling test; : In total, 17 male endurance-trained athletes [7 cyclists and 10 triathletes, age 33.2 ± 6.9 yr, workload at maximal lactate steady state (MLSS) 268 ± 27 W] participated in the study.

Content Validity of a New Soccer (Football) Return-to-Play Test: The RONDO-TEST.

Objectives: The aim was to assess the content validity of a new field test on general and soccer-specific motor skills before return to play.

Methods: The RONDO-TEST was assessed by a Delphi panel for its content validity. It included a survey to evaluate 16 items related to the test consisting of four 10 m lines which cross over at their mid-point, resulting in eight 5 m sectors that include locomotor skills (speeding, moving sideways, side cutting, and jumping) and soccer-specific technical skills (dribbling, slalom course, and kicking/passing).

The Trail Runners' Tendon-How Do Weekly Mileage and Elevation Gain Affect Achilles and Patellar Tendon Morphology?

: Unlike road running, mountain and trail running typically cover longer distances and include uphill and downhill segments that impose unique physiological and mechanical demands on athletes. : This study aimed to identify morphological differences in the patellar and Achilles tendons between trail and road runners. Moreover, the potential influence of weekly mileage and accumulated positive elevation gain on the morphology of both tendons was obtained.

Zirconia Barriers in Bone Regeneration Procedures: A Scoping Review.

Purpose: To identify the current status and development of zirconia barriers in bone augmentation procedures in the maxillofacial area of adult human patients.

Materials And Methods: Two independent reviewers conducted an electronic literature search in PubMed/MEDLINE, Web of Science, Scopus, EBSCO, the Cochrane Library, and LILACS databases, as well as a manual search to identify eligible clinical studies up to April 15, 2024. The protocol was designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines.

Outcomes of a Pilot Newborn Screening Program for Spinal Muscular Atrophy in the Valencian Community.

Spinal muscular atrophy (SMA) is a degenerative neuromuscular condition resulting from a homozygous deletion of the survival motor neuron 1 () gene in 95% of patients. A timely diagnosis via newborn screening (NBS) and initiating treatment before the onset of symptoms are critical for improving health outcomes in affected individuals. We carried out a screening test by quantitative PCR (qPCR) to amplify the exon seven of using dried blood spot (DBS) samples.

Effects of Aquatic Exercise in Older People with Osteoarthritis: Systematic Review of Randomized Controlled Trials.

In this study, the objective is to analyze the efficacy of different aquatic physical exercise programs in the treatment of osteoarthritis in older people. The systematic review was conducted until April 2024 and updated in November 2024 in five electronic databases. Randomized controlled studies in people over 60 years of age with a diagnosis of osteoarthritis were included.

Participation as a Pillar of Active Ageing: The Role of Eudaimonic Psychological and Health Factors.

With ageing population projections, promoting positive ageing trajectories is critical. While health is often emphasised, eudaimonic psychological factors remain underexamined. A qualitative study presented throughout the main text highlighted the importance of psychological factors like purpose in life and resilience in fostering participation and subjective well-being, even amidst declining health.

COVID-19 and Mental Distress and Well-Being Among Older People: A Gender Analysis in the First and Last Year of the Pandemic and in the Post-Pandemic Period.

The Coronavirus disease 2019 (COVID-19) pandemic seriously threatened the health and well-being of the population. This study aims to investigate the relevance of the COVID-19 pandemic on the stress, mental distress, and well-being of older people in Spain. The design was quantitative repeated cross-sectional.

Improving Sleep Quality and Well-Being in Institutionalized Older Adults: The Potential of NESA Non-Invasive Neuromodulation Treatment.

: Ageing is associated with several cognitive, physical, and emotional changes, including a decrease in sleep quality and mental health issues. This study studies NESA (Spanish acronym for Neuromodulación Superficial Aplicada) non-invasive neuromodulation using microcurrents as something that may provide a potential improvement in the quality of sleep and general health of older adults and residents in a healthcare institution. : This observational study recruited 24 people who were residents at a long-term care facility.

The Classification and Language Description of Patients with Primary Progressive Aphasia Using the Mini Linguistic State Examination Test.

Primary progressive aphasia (PPA) is a clinical syndrome characterized by a progressive deterioration in language and speech. It is classified into three variants based on symptom patterns: logopenic, semantic, and non-fluent. Due to the lack of fully reliable and valid screening tests for diagnosing PPA and its variants, a Spanish version of the Mini Linguistic State Examination (MLSE) has recently been introduced.

Impairment of the Functional Status and Decrease in Albumin in Frail Older People After a COVID-19 Outbreak: A Descriptive Study in a Long-Term Care Facility in Chile.

Frailty is a common condition among older individuals and is associated with increased vulnerability to adverse health outcomes. The COVID-19 pandemic further highlighted the impact of viral infections on frail populations. The present work aimed to determine frailty, functional and cognitive status, and clinical analysis of older persons in a long-term care facility in Chile, before and following the outbreak of COVID-19.

Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity.

Dietary exposure to the plasticiser bisphenol A (BPA), an obesogenic and endocrine disruptor from plastic and epoxy resin industries, remains prevalent despite regulatory restriction and food safety efforts. BPA can be accumulated in humans and animals, potentially exerting differential health effects based on individual metabolic capacity. This pilot study examines the impact of direct ex vivo BPA exposure on the gut microbiota of obese and normal-weight children, using 16S rRNA amplicon sequencing and anaerobic culturing combined methods.

Removal of Ibuprofen in Water by Bioaugmentation with CSW11 Isolated from Sewage Sludge-Assessment of Biodegradation Pathway Based on Metabolite Formation and Genomic Analysis.

Ibuprofen (IBP) is one of the most consumed drugs in the world. It is only partially removed in wastewater treatment plants (WWTPs), being present in effluent wastewater and sewage sludge, causing the widespread introduction of IBP as an emergent xenobiotic in different environmental compartments. This study describes the use of CSW11, recently described as an IBP degrader, through bioaugmentation processes for the removal of IBP from water under different conditions (additional carbon sources, various concentrations of glucose and IBP).

Life history data derived from the dental histological analysis of Giraffa camelopardalis: Implications for the palaeohistology of extinct giraffids.

The analysis of incremental marks in the enamel, dentine and cementum of extant and extinct species provides important information about the rate and pattern of tooth growth, which permits inferences about key life history traits. Traditionally, such research has mainly focused on primates, while other mammalian groups have remained relatively unexplored. In some cases, this has led to the misidentification of incremental markings and the miscalculation of dental growth parameters in non-primate taxa, which has highlighted the importance of obtaining more reliable comparative frameworks.

7. Cervical facet pain: Degenerative alterations and whiplash-associated disorder.

Introduction: Pain from the cervical facet joints, either due to degenerative conditions or due to whiplash-related trauma, is very common in the general population. Here, we provide an overview of the literature on the diagnosis and treatment of cervical facet-related pain with special emphasis on interventional treatment techniques.

Methods: A literature search on the diagnosis and treatment of cervical facet joint pain and whiplash-associated disorders (WAD) was performed using PubMed, Cochrane, and Embase databases.