Avatrombopag in adults with immune thrombocytopenia: A multicentre real-life observational study in Madrid, Spain (AVAMAD study).

Immune thrombocytopenia (ITP) is a rare acquired disorder where thrombopoietin-receptor agonists have become mainstays of ITP treatment. With the recent approval of avatrombopag (AVA), real-world studies are essential to evaluate its efficacy and safety. Our study of 66 adult ITP patients treated with AVA showed a high response rate.

A Pairwise and Network Meta-analysis of Anti-inflammatory Strategies After Myocardial Infarction: the TITIAN study.

Background And Aims: Multiple anti-inflammatory drugs have been tested for secondary prevention after myocardial infarction (MI), giving mixed results and questioning the efficacy of anti-inflammatory therapy. No head-to-head comparisons between anti-inflammatory drugs have been performed. This study aimed to compare the efficacy and safety of anti-inflammatory drugs for secondary prevention after MI and the relative merits of specific drugs and administration strategies.

Multiple environmental tracers combined with a constrained Bayesian isotope mixing model to elucidate nitrate and sulfate contamination in a coastal groundwater system.

Several groundwater quality investigations have been conducted in coastal regions that are commonly exposed to multiple anthropogenic stressors. Nonetheless, such studies remain challenging because they require focused-diagnostic approaches for a comprehensive understanding of groundwater contamination. Therefore, this study integrates a multi-tracer approach to acquire comprehensive information allowing for an improved understanding of the origins of groundwater contamination, the relative contribution of contaminants, and their biogeochemical cycling within a coastal groundwater system.

Model-based scenario analysis to support the operation of solar photo-Fenton plants.

Model-based tools applied to wastewater management have been identified as an emerging solution to address the associated challenges related to the optimization of the technologies, meeting more restricted water quality standards. Thus, for the first time, the demonstration of the solar photo-Fenton process for microcontaminant removal in the operating environment of a model-based tool is reported. This tool aids in determining the right cost-effective seasonal strategy for a 37-m demonstration-scale photoreactor operating in a rural wastewater treatment plant.

Evaluation of decision-support tools for coastal flood and erosion control: A multicriteria perspective.

Coastal areas face significant challenges due to natural and anthropogenic changes, such as sea level rise, extreme events and coastal erosion. The coastal management requires the consideration of socioeconomic and environmental factors to address these variables. The selection of an appropriate Decision Support Tool (DST) based on decision matrix method plays a crucial role in implementing coastal management strategies to tackle climate change-related issues.

Amplified impacts of human activities: Non-linear responses of riverine microbial communities to distribution of land use.

Rapid global urbanization poses considerable ecological risks to freshwater systems, notably leading to substantial reductions in microbial communities. To assess the impacts of human activities on these communities, we applied the high-throughput amplicon DNA sequencing to examine spatial variations in riverine microbial communities within an urbanized watershed. Coupled with the Geographical Detector Model, the effects of the land use were identified across the watershed.

Beyond conventional characterization: Defect engineering role for sensitivity and selectivity of room-temperature UV-assisted graphene-based NO₂ sensors.

The term graphene-based gas sensors may be too broad, as there are many physicochemical differences within the graphene-based materials (GBM) used for chemiresistive gas sensors. These differences condition the sensitivity, selectivity, recovery, and ultimately the sensing performance of these devices towards air pollutants. Continuous ultraviolet irradiation aids in the desorption of gas molecules and enhances sensor performance.

Impact of NPK fertilization on the metabolomic profile and nutritional quality of Portulaca oleracea L. using nuclear magnetic resonance analysis.

Purslane is a plant with high nutritional content that is mainly produced in the central part of Mexico. The nutritional content of purslane depends on various factors such as climatic and soil conditions, phenology, and fertilization. This article describes the H NMR metabolomics profiling of purslane in relation to fertilization at two harvest stages: C and C (27 and 42 days after emergence).

Application of FTIR spectroscopy to infer ante- and post-mortem changes in archaeological human bone.

Several studies have used Fourier Transform Infrared Spectroscopy (FTIR) to assess chemical and structural changes caused by diagenesis in archaeological human bone, whereas other factors such as individual's biological profile (sex and age) or the type of bone have seldom been considered. In this study transmission FTIR was applied to 51 bone samples from 19 post-Roman individuals of A Lanzada necropolis (NW Spain). Mid-infrared (MIR) indices (IRSF, MMI, C/P, C/C, Am/P, BPI, API, AmI/AmII) were also calculated and principal component analysis (PCA) was used to explore peak ratios and differences across the whole spectrum.

Older family caregivers and health professionals of adults with intellectual disabilities: Qualitative results of the first-phases of the adaptation of the Savvy Caregiver Program through the ADAPT-ITT model.

Adults with intellectual disabilities are living longer, leading to an increasing need for older family caregivers to provide long-term care. To date, many studies have focused primarily on interventions to support caregivers of children with disabilities and elderly with dementia. For this reason, this study focuses on adapting the Savvy Caregiver Programme.

Factors influencing oocyte recovery during ultrasound-guided follicle aspiration in mares: A postmortem study.

The objectives of this study were to investigate the influence of different OPU variables (vacuum and injection pressures during follicle aspiration and flushing, needle twisting to scrape follicles, number of follicle flushes and type of flushing media) on oocyte recovery rate (ORR) and morphology. Overall, 120 postmortem excised ovaries were processed in 62 replicates (1.9 ± 0.

The structure of meaning in schizophrenia: A study of spontaneous speech in Chinese.

Narrative speech production requires the retrieval of concepts to refer to entities, which need to be referenceable more than once for any form of narrative coherence to arise. Such coherence has long been observed to be affected in schizophrenia spectrum disorders (SSD), yet the underlying mechanisms have been a longstanding puzzle, with existing evidence predominantly derived from Indo-European languages. Here we analyzed two picture descriptions from 22 native Mandarin Chinese speakers with SSD and 15 healthy controls.

Bone regeneration in sheep model induced by strontium-containing mesoporous bioactive glasses.

Local delivery of therapeutic ions from bioactive mesoporous glasses (MBGs) is postulated as one of the most promising strategies for regenerative therapy of critical bone defects. Among these ions, Sr cation has been widely considered for this purpose as part of the composition of MBGs. MBGs of chemical composition 75SiO-25-x CaO-5PO-xSrO with x = 0, 2.

Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.

Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 2014, unites a worldwide community dedicated to understanding the impact of T21 on biological systems and improving the quality of life of people with DS across the lifespan. T21RS hosts an international conference every two years to support collaboration, dissemination, and information sharing for this goal.

Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.

Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.

Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.

Changes in CD4 T cells subsets in patients with alcohol-related cirrhosis.

Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment.

A word of caution in the functional monitoring of patients after rectal cancer surgery: a multicentre observational study.

Background: Patients with rectal cancer often experience adverse effects on urinary, sexual, and digestive functions. Despite recognised impacts and available treatments, they are not fully integrated into follow-up protocols, thereby hindering appropriate interventions. The aim of the study was to discern the activities conducted in our routine clinical practice outside of clinical trials.

Feasibility study of hyperspectral colposcopy as a novel tool for detecting precancerous cervical lesions.

Cervical cancer remains a major global health concern, with a specially alarming incidence in younger women. Traditional detection techniques such as the Pap smear and colposcopy often lack sensitivity and specificity and are highly dependent on the experience of the gynaecologist. In response, this study proposes the use of Hyperspectral Imaging, a pioneering technology that combines traditional imaging with spectroscopy to provide detailed spatial and spectral information.

Leveraging U-Net and selective feature extraction for land cover classification using remote sensing imagery.

In this study, we explore an enhancement to the U-Net architecture by integrating SK-ResNeXt as the encoder for Land Cover Classification (LCC) tasks using Multispectral Imaging (MSI). SK-ResNeXt introduces cardinality and adaptive kernel sizes, allowing U-Net to better capture multi-scale features and adjust more effectively to variations in spatial resolution, thereby enhancing the model's ability to segment complex land cover types. We evaluate this approach using the Five-Billion-Pixels dataset, composed of 150 large-scale RGB-NIR images and over 5 billion labeled pixels across 24 categories.

Prevalence of anhedonia in women with deep endometriosis.

Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly presented with chronic pelvic pain. This cross-sectional study reports, for the first time, the prevalence of anhedonia in a sample comprised by 212 premenopausal women with suspected DE referred to a tertiary hospital.

Effect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron.

Background: Prevention of iron deficiency in suckling piglets by intramuscular injection of a standardized amount of iron dextran or gleptoferron in the first days of life can lead to over- or underdosage with respective health risks. Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible.

Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities.

Background: A didelphic uterus represents a unique and infrequent congenital condition in which a woman possesses two distinct uteri, each with its own cervix. This anomaly arises due to partial or incomplete merging of the Müllerian ducts during the developmental stages in the womb. Accounting for uterine malformations, a didelphic uterus is a relatively rare condition, affecting approximately 0.

Functional fitness and psychological well-being in older adults.

Background: Physical fitness and functioning are related to better mental health in older age. However, which fitness components (body composition, strength, flexibility, coordination, and endurance) are more closely related to psychological well-being (PWB) is unclear.

Methods: This research examined how body mass index (BMI) and six indices of functional fitness (i.