Impact of Lewis Acids on the Reactivity of a High-Valent Cu(III) Complex.

Redox-inactive metal ions functioning as Lewis acids (LA) play a significant role in modulating the redox reactivity of metal-oxygen intermediates such as metal-oxo, metal-superoxo, and metal-peroxo species. In photosystem II (PS-II), the redox-inactive metal ion Ca is critical for O activation, although its precise function remains unclear. Inspired by nature's use of redox-inactive metal ions, this study aims to characterize complexes of high-valent Cu(III) bound Lewis acids, (where M = Zn, Eu, Yb, and Sc), through various spectroscopic techniques, including UV-vis and resonance Raman spectroscopic analyses.

European cancer mortality predictions for the year 2025 with focus on breast cancer.

Background: We predicted the number of cancer deaths and rates for 2025 in the European Union (EU), its five most populous countries, and the UK, focusing on breast cancer.

Materials And Methods: We derived population data and death certificates for all cancers and major sites for the EU, France, Germany, Italy, Poland, Spain, and the UK since 1970, from the World Health Organization and United Nations databases. Estimates for 2025 were computed by linear regression on recent trends identified through Poisson joinpoint regression, considering the slope of the most recent trend segment.

Healthy nudges: exploring their variability, limitations, and future challenges.

Objective: To review several behavioral economics-based interventions ("healthy nudges") aimed at mitigating the overuse and underuse of healthcare resources -phenomena associated with poorer health outcomes and increased costs.

Method: A comparative case study approach is used to assess the effectiveness of ten studies designed to improve treatment adherence and prevent underuse, as well as those focused on improving prescribing practices to address overuse.

Results: First, healthy nudges are generally effective, although there is considerable variability in their outcomes.

Survey on the practice of skin-to-skin contact in Spanish neonatal units during the first days of life. Influence of the presence of umbilical catheters.

Introduction: Skin-to-skin contact (SSC) offers multiple benefits in preterm newborns (PTNBs), but its implementation can be delayed due to the presence of some devices such as umbilical venous catheters (UVCs). Our objective was to evaluate the practice of SSC in PTNBs in Spanish neonatal units and how the type of catheter affects its initiation.

Methods: We distributed a survey through the Sociedad Española de Neonatología to Spanish neonatal units, analyzing the timing of SSC initiation and the influence on this practice of the types of devices being used.

Most common flood-associated infectious diseases in children.

Floods constitute one of the most widely described natural phenomena worldwide, and their frequency is increasing due to the consequences of climate change. Floods pose risks to the affected populations, including an increase in communicable diseases mainly due to population displacement and overcrowding, deficiencies in hygiene and dietary measures and difficulties accessing health care. The most frequently reported infectious diseases in the context of these disasters are gastrointestinal and respiratory diseases and diseases resulting from wound infection.

The links between soil and water pollution and cardiovascular disease.

Soil and water pollution represent significant threats to global health, ecosystems, and biodiversity. Healthy soils underpin terrestrial ecosystems, supporting food production, biodiversity, water retention, and carbon sequestration. However, soil degradation jeopardizes the health of 3.

Mirror Therapy in Unilateral Amputee Patients With Phantom Limb Pain.

Unlabelled: Up to 90% of amputee patients have phantom limb pain (PLP), which is difficult to treat. The aim of this study was to assess the medium and long-term efficacy of mirror therapy (MT) in unilateral amputee adults with PLP.

Methods: We carried out an uncontrolled prospective longitudinal study.

Capturing complete arch implant positions in two partial photogrammetry scans: Does it impact the accuracy of complete arch implant scans?

Statement Of Problem: Extraoral photogrammetry (PG) systems can record implant positions in 1 scan or in 2 scans that are then merged. However, the accuracy of implant positions recorded in 2 partial photogrammetry scans is unknown.

Purpose: The purpose of this in vitro study was to compare the accuracy of complete arch implant scans recorded in 1 or 2 scans by using 3 extraoral PG systems.

The IL-6 axis in vascular inflammation: effects of IL-6 receptor blockade on vascular lesions from patients with giant-cell arteritis.

Objectives: Blocking interleukin (IL)-6-receptor with tocilizumab has been a major advance in the treatment of giant-cell arteritis (GCA), supporting a crucial role of IL-6 receptor signalling. However, nearly half of the patients are not able to maintain glucocorticoid- free remission with tocilizumab. The impact of tocilizumab on vascular lesions of GCA is largely unknown since conflicting results have been obtained by imaging.

Building upon the core elements of antifungal stewardship: practical recommendations for effective antifungal stewardship in resource-limited settings.

Introduction: Despite the crucial importance of effective AFS in resource-limited settings, such settings remain comparatively underserved and underrepresented in terms of resource-setting-specific guidance and research. Further practical contextualization and application of current AFS best practices is thus necessary.

Areas Covered: A panel of leading experts from diverse countries (India, Nigeria, Spain, and the US) was brought together to provide recommendations for practical and effective implementation of AFS in resource-limited settings.

Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory.

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.

Efficacy of Acoramidis on All-Cause Mortality and Cardiovascular Hospitalization in Transthyretin Amyloid Cardiomyopathy.

Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed chronic disease associated with progressive heart failure that results in impaired quality of life, repeated hospitalizations, and premature death. Acoramidis is a selective, oral transthyretin stabilizer recently approved by the U.S.

An expanded framework for Swab Touch Spray-Mass Spectrometry towards the detection of allergenic protein residues on food preparation surfaces.

Background: Ambient Mass Spectrometry (AMS) encompasses a group of techniques that have emerged as powerful strategies for direct, in-situ and high-throughput analysis, also in compliance with the principles of green analytical chemistry. Swab Touch Spray-Mass Spectrometry (Swab TS-MS) is a home-made AMS technique that involves the use of a medical swab as sampling tool and electrospray probe. To date, Swab TS-MS has been applied only for the analysis of small molecules, especially in forensic and medical fields, leaving the analysis of peptides and proteins still unexplored.

Brain laterality of numbers and calculation: Complex networks and their development.

This chapter reviews notions about the lateralization of numbers and calculation in the brain, including its developmental pattern. Such notions have changed dramatically in recent decades. What was once considered a function almost exclusively located in the left hemisphere has been found to be sustained by complex brain networks encompassing both hemispheres.

Hemispheric asymmetries, paleoneurology, and the evolution of the human genus.

Brain asymmetries are a distinctive feature of Homo sapiens and are associated with key evolutionary functions including language and handedness. Nonetheless, differences between humans and apes could be just a matter of degree and size and not the expression of unique traits of our species. In this chapter, I introduce paleoneurology and the study of brain morphology in fossil hominids, reviewing the anatomic factors that can influence the main asymmetries of the endocranial cavity (cortical volumes, sulcal patterns, and craniovascular features).

LDL cholesterol levels and treatment intensity in secondary prevention of patients with ischemic heart disease in the primary care setting: a real-world data registry study.

Background: Monitoring LDL cholesterol (LDL-C) and prescribing appropriate treatment is crucial for secondary prevention in primary care.

Aim: We studied LDL-C levels and treatments for ischemic heart disease patients according to target recommendations and assessed factors influencing prescribed drug intensity.

Design & Setting: We examined electronic health records of patients with ischemic heart disease from three primary care centers.

Association of ceramide risk scores with rheumatoid arthritis: a FINRISK population-based cohort study.

Objectives: This study aimed to explore the association between lipid-based Cardiovascular Event Risk Tests (CERT1 and CERT2), including ceramides (Cer) and phosphatidylcholine (PC) lipid species, and rheumatoid arthritis (RA), an inflammatory disease that can increase the risk of cardiovascular diseases.

Design: Prospective population-based cohort study.

Setting: Primary care centres across five geographical areas in Finland.

Artificial intelligence for weight estimation in paediatric emergency care.

Objective: To develop and validate a paediatric weight estimation model adapted to the characteristics of the Spanish population as an alternative to currently extended methods.

Methods: Anthropometric data in a cohort of 11 287 children were used to develop machine learning models to predict weight using height and the body mass index (BMI) quartile (as surrogate for body habitus (BH)). The models were later validated in an independent cohort of 780 children admitted to paediatric emergencies in two other hospitals.