760,763 results match your criteria: "Spain; Maimonides Biomedical Research Institute of Cordoba[Affiliation]"
J Exerc Sci Fit
January 2025
Faculty of Health Sciences, EVOPRED Research Group, Universidad Europea de Canarias, La Orotava, Tenerife, Spain.
Background: : Neuromuscular re-education has focused on improving motor activities in patients with pathologies by retraining the nervous system. However, this has not yet been investigated in healthy individuals. Voluntary isometric contractions at maximal muscle shortening (VICAMS) is a new technique with the same objective.
View Article and Find Full Text PDFiScience
January 2025
Section of Cell Biology and Functional Genomics, Department of Medicine, Endocrinology and Metabolism, Imperial College London, London, UK.
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of beta cell function. Here, we show that an lncRNA-transcribed antisense to Pax6, annotated as Pax6os1/PAX6-AS1, was upregulated by high glucose concentrations in human as well as murine beta cell lines and islets. Elevated expression was also observed in islets from mice on a high-fat diet and patients with type 2 diabetes.
View Article and Find Full Text PDFiScience
January 2025
Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain.
Alternative splicing is a post-transcriptional process resulting in multiple protein isoforms from a single gene. Abnormal splicing may lead to metabolic diseases, including type 2 diabetes mellitus (T2DM). To identify the splicing factor expression that predicts T2DM remission in coronary heart disease (CHD) patients, we identified newly diagnosed T2DM at baseline ( = 190) from the CORDIOPREV study.
View Article and Find Full Text PDFJPRAS Open
March 2025
Plastic and Reconstructive Surgery Department, Hospital Clinic of Barcelona, Barcelona, Spain.
Introduction: Different vessel diameters may challenge the completion of a high-quality anastomosis in microsurgery. In clinical practice, discrepancies in vessel size are commonly encountered. These variations can range from small to moderate, and microsurgeons typically employ established techniques, such as dilating the smaller vessel or creating an oblique cut in its wall, to address these differences.
View Article and Find Full Text PDFERJ Open Res
January 2025
Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Introduction: Achieving an early diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) in pulmonary embolism (PE) survivors results in better quality of life and survival. Importantly, dedicated follow-up strategies to achieve an earlier CTEPH diagnosis involve costs that were not explicitly incorporated in the models assessing their cost-effectiveness. We performed an economic evaluation of 11 distinct PE follow-up algorithms to determine which should be preferred.
View Article and Find Full Text PDFERJ Open Res
January 2025
CIBER Enfermedades Respiratorias, Madrid, Spain.
Introduction: Exacerbations of COPD decrease physical activity. Physical activity interventions after these events are desirable but have had mixed results. Understanding the barriers to and enablers of physical activity may help to improve the results of these interventions.
View Article and Find Full Text PDFERJ Open Res
January 2025
Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain.
Introduction: Exposure to environmental factors ( air pollution and second-hand tobacco smoke) have been associated with impaired lung function. However, the impact of environmental factors on lung health is usually evaluated separately and not with an exposomic framework. In this regard, breath analysis could be a noninvasive tool for biomonitoring of global human environmental exposure.
View Article and Find Full Text PDFData Brief
February 2025
CREA - Council for Agricultural Research and Economics, Research Centre for Agriculture and Environment, I-40128 Bologna, Italy.
Farming practices such as soil tillage, organic/mineral fertilization, irrigation, crop selection and residues management influence multiple ecosystem services provided by agricultural systems. These practices exhibit complex, non-linear interrelationships that affect crop productivity, water quality, and non-carbon dioxide greenhouse gases (GHG) emissions, possibly offsetting their benefits regarding soil organic carbon (SOC) sequestration. Current methodologies from the Intergovernmental Panel on Climate Change (IPCC) for assessing the impacts of alternative farming practices on GHG emissions rely on global or country-specific coefficients.
View Article and Find Full Text PDFData Brief
February 2025
Estación Experimental de Aula Dei, EEAD - CSIC, Ave. Montañana 1005, 50059 Zaragoza, Spain.
The dataset [1] hosts pedological info and images of the lands -locally known as - of the outcropping gypsiferous core of the Barbastro-Balaguer anticline (Fig. 1). It stands out in the landscape for the linear reliefs due to outcrops of dipping strata with differential resistance to erosion, and also because of its whitish color (Fig.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Materials Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Utrecht 3584 CG, The Netherlands.
Machine learning potentials (MLPs) offer efficient and accurate material simulations, but constructing the reference ab initio database remains a significant challenge, particularly for catalyst-adsorbate systems. Training an MLP with a small data set can lead to overfitting, thus limiting its practical applications. This study explores the feasibility of developing computationally cost-effective and accurate MLPs for catalyst-adsorbate systems with a limited number of ab initio references by leveraging a transfer learning strategy from subsets of a comprehensive public database.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Departament de Ciència de Materials i Química Física & Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, c/Martí i Franquès 1-11, 08028 Barcelona, Spain.
First-principles density functional theory calculations are carried out on the (TiO) cluster supported on the TiCT (0001) surface with different chemical terminations, , -H, -O, and -OH, to study the interaction and understand the TiCT functionalization effect on the formation of (TiO)/TiCT composites. Results show an exothermic interaction for all cases, whose strength is driven by the surface termination, promoting weaker bonds when the MXene is functionalized with H atoms. For TiCH and TiC(OH) MXenes, the interaction is accompanied by a charge transfer towards the titania cluster.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC - Universidad de Zaragoza, Plaza San Francisco s/n, Zaragoza 50009, Spain.
A strategy toward the realization of a quantum spin processor involves the coupling of spin qubits and qudits to photons within superconducting resonators. To enable the realization of such hybrid architecture, here we first explore the design of a chip with multiple lumped-element LC superconducting resonators optimized for their coupling to distinct transitions of a vanadyl porphyrin electronuclear qudit. The controlled integration of the vanadyl qudit onto the superconducting device, both in terms of number and orientation, is then attained using the formation of nanosheets of a 2D framework built on the vanadyl qudit as a node.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Institute de Quimica Computacional i Catálisi, Universitat de Girona, Girona 17003 Spain.
Creating sustainable and stable semiconductors for energy conversion via catalysis, such as water splitting and carbon dioxide reduction, is a major challenge in modern materials chemistry, propelled by the limited and dwindling reserves of platinum group metals. Two-dimensional hexagonal borocarbonitride (h-BCN) is a metal-free alternative and ternary semiconductor, possessing tunable electronic properties between that of hexagonal boron nitride (h-BN) and graphene, and has attracted significant attention as a nonmetallic catalyst for a host of technologically relevant chemical reactions. Herein, we use density functional theory to investigate the stability and optoelectronic properties of phase-separated monolayer h-BCN structures, varying carbon concentration and domain size.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Department of Mechanical Engineering and Technology Management, Norwegian University of Life Sciences, N-1433 AS, Norway.
Hybrid molecular ferroelectrics with orientationally disordered mesophases offer significant promise as lead-free alternatives to traditional inorganic ferroelectrics owing to properties such as room temperature ferroelectricity, low-energy synthesis, malleability, and potential for multiaxial polarization. The ferroelectric molecular salt HdabcoClO is of particular interest due to its ultrafast ferroelectric room-temperature switching. However, so far, there is limited understanding of the nature of dynamical disorder arising in these compounds.
View Article and Find Full Text PDFJ Immunother Precis Oncol
February 2025
Department of Health Services and Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Introduction: Treatment guidelines for immune-related inflammatory arthritis (irAE-IA) in patients with cancer receiving immune checkpoint inhibitors (ICIs) are vague with respect to the use of specific agents. Patients are usually referred to rheumatologists for treatment. We conducted a survey of expert rheumatologists to determine current practices.
View Article and Find Full Text PDFSports Med Health Sci
March 2025
FPCEE-Blanquerna, Ramon Llull University, Barcelona, Spain.
Impairments on body function, activities of daily living (ADL) and cognition are common after stroke. Eccentric resistance training (ERT) may be implemented to improve them. The primary objectives were to evaluate whether ERT improves body function, ADL and cognition after stroke.
View Article and Find Full Text PDFCondition monitoring and fault classification in engineering systems is a critical challenge within the scope of Prognostics and Health Management (PHM). The fault diagnosis of complex nonlinear systems, such as hydraulic systems, has become increasingly important due to advancements in big data analytics, machine learning (ML), Industry 4.0, and Internet of Things (IoT) applications.
View Article and Find Full Text PDFSoil contamination by heavy metals (HM) is a critical area of research. Traditional methods involving sample collection and lab analysis are effective but costly and time-consuming. This study explores whether geostatistical analysis with GIS and open data can provide a faster, more precise, and cost-effective alternative for HM contamination assessment without extensive sampling.
View Article and Find Full Text PDFCurr Res Food Sci
December 2024
Institute of Agrochemistry and Food Technology (IATA, CSIC), Spain.
Food structure modification by increasing viscosity or adding heterogeneity to the food product has shown to effectively change food oral processing. In this study, it was hypothesized that the addition of gas to purees could affect oral processing. This was achieved by creating different structures in purees using a gas syphon, vacuum and syphon + vacuum.
View Article and Find Full Text PDFACS Med Chem Lett
January 2025
Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l'Alimentació - Campus Torribera, Universitat de Barcelona, Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain.
Assessing the binding mode of drug-like compounds is key in structure-based drug design. However, this may be challenged by factors such as the structural flexibility of the target protein. In this case, state-of-the-art computational methods can be valuable to explore the linkages between structural and pharmacological data.
View Article and Find Full Text PDFACS Med Chem Lett
January 2025
NEUROFARBA Department, Section of Pharmaceutical Science, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
The tetrazole group is here proposed as a zinc-binding warhead for the inhibition of the metalloenzyme carbonic anhydrases. A set of synthesized derivatives incorporating the tetrazole moiety were evaluated as inhibitors against a panel of human isoforms, exhibiting values spanning between the submicromolar and low-to-medium micromolar ranges (0.62-19.
View Article and Find Full Text PDFFront Psychol
December 2024
Department of Neurology, Harvard Medical School, Boston, MA, United States.
Objective: This study examined the psychometric properties of a newly developed scale for measuring subjective cognitive reserve (SCR) across multiple domains, including nutrition, physical condition, sleep, cognition, willingness to learn, socialization, general health, and life plan.
Method: The relationship between SCR scores and other established measures of cognitive reserve and subjective cognitive decline was also explored. A sample of 402 healthy participants aged 18 to 79 years took part in the study.
Eur Urol Open Sci
January 2025
Department of Urology, Hospital Universitari de Bellvitge, Barcelona, Spain.
The indication for kidney transplantation over a urinary diversion (UD) for patients with severe lower urinary tract dysfunction and end-stage renal disease is a controversial issue. Thanks to advances in robot-assisted kidney transplant (RAKT) programs, the boundaries are being pushed further. We present the first RAKT series reported for patients undergoing simple cystectomy and UD for benign bladder disease.
View Article and Find Full Text PDFRev Panam Salud Publica
January 2025
Blue Sky Development Consulting Port of Spain Trinidad and Tobago Blue Sky Development Consulting, Port of Spain, Trinidad and Tobago.
This paper delineates the development of the Caribbean Research for Action Agenda which aims to empower Caribbean Small Island Developing States to reduce their vulnerabilities to the effects of climate change on health. The Caribbean Research for Action Agenda emerged from collaboration between nongovernmental organizations, academic institutions, and multilateral agencies that organized a conference on climate change and health in the Caribbean. This Agenda was formulated by prioritizing research areas, synthesizing evidence from conference presentations and scientific literature, and holding consultations with stakeholders and experts.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Department of Cardiology, Hospital Universitario de La Princesa, IIS-IP, CIBER-CV, Universidad Autónoma Madrid, Madrid, Spain.