Management of Psychosis and Schizophrenia by Primary Care GPs: A Cross-Sectional Study in Spain.

Aim: To investigate the detection and initial management of first psychotic episodes, as well as established schizophrenia, within the primary care of the Andalusian Health System.

Background: Delay in detecting and treating psychosis is associated with slower recovery, higher relapse risk, and poorer long-term outcomes. Often, psychotic episodes go unnoticed for years before a diagnosis is established.

Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.

Importance: Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.

A Phase 3B, Open-Label Study to Evaluate the Immunogenicity and Safety of the Quadrivalent Meningococcal Nimenrix Vaccine When Given to Healthy Infants at 3 and 12 Months of Age.

Introduction: Infants and young children typically have the highest age-related risk of invasive meningococcal disease. The immunogenicity and safety of a single primary dose and a booster of a meningococcal A/C/W/Y tetanus toxoid conjugate vaccine (MenACWY-TT; Nimenrix) in infants were evaluated.

Methods: In this phase 3b, open-label, single-arm study, healthy 3-month-old infants received a single Nimenrix dose followed by a booster at age 12 months (1 + 1 series).

Cancers of the brain and central nervous system: global patterns and trends in incidence.

Background: Global comparisons of the burden and impact of cancers of the brain and central nervous system (CNS) are critical for developing effective control strategies and generating etiological hypotheses to drive future research.

Methods: National incidence estimates were obtained from GLOBOCAN 2022, and recorded incidence data from the Cancer in Five Continents series, both developed and compiled by the International Agency for Research on Cancer. We examined the estimated age-standardized incidence rates in 185 countries, as well as time trends in recorded incidence in 35 countries, quantifying the direction and change in the magnitude of the rates using the estimated average percentage change (EAPC).

Medical teleconsultation from the patient's perspective. A demographic segmentation.

Medical teleconsultation is a tool that is here to stay among the services offered by health systems. Therefore, it is important to understand the process of adopting this technology. However, most studies have endorsed the point of view of health professionals.

European Survey on Adults with Type 1 Diabetes and their Caregivers: Insights into Personal Experience and Needs for Improving Diabetes Care.

Introduction: Type 1 diabetes (T1D) requires constant self-management and substantially impacts daily life. We surveyed the experiences/burdens of people with T1D (PWD) and their caregivers.

Methods: An online survey of PWD/caregivers (aged ≥ 18 years) living in five European countries was conducted from July to August 2021.

Human-biting behaviour of Leptoconops irritans (Diptera: Ceratopogonidae) in a touristic area of the Balearic Islands (Spain).

Biting midges of genus Leptoconops Skuse 1889 are small blood-feeding insects recognized as highly irritating diurnal pests in certain regions around the globe. In Europe, their presence is poorly documented, except in France and Italy. Following reports of human discomfort in a tourist area of Menorca, Balearic Islands (Spain), a small-scale study was conducted to identify the biting species and assess their preferred biting sites using a human-landing assay along a habitat gradient in a coastal dune area.

Gonadal miRNomes and transcriptomes in infected fish reveal sexually dimorphic patterns of the immune response.

Fish disease outbreaks caused by bacterial burdens are responsible for decreasing productivity in aquaculture. Unraveling the molecular mechanisms activated in the gonads after infections is pivotal for enhancing husbandry techniques in fish farms, ensuring disease management, and selecting the most resilience phenotype. The present study, with an important commercial species the European sea bass (Dicentrarchus labrax), an important commercial species in Europe, examined changes in the miRNome and transcriptome 48 h after an intraperitoneal infection with Vibrio anguillarum.

A systematic review on whole-body photobiomodulation for exercise performance and recovery.

Purpose: Photobiomodulation (PBM) is a non-invasive therapeutic procedure that consists of irradiating a local area of the skin with red and near-infrared lasers or light emitting diodes (LEDs). Local PBM has been studied as a method to improve exercise performance and recovery. This review aims to evaluate the efficacy of whole-body PBM for exercise performance and recovery, comparing its findings to the established effects of localized PBM.

European central hypoventilation syndrome consortium description of congenital central hypoventilation syndrome neonatal onset.

Unlabelled: It is known that in most cases of congenital central hypoventilation syndrome (CCHS), apnoeas and hypoventilation occur at birth. Nevertheless, a detailed description of initial symptoms, including pregnancy events and diagnostic tests performed, is warranted in infants with neonatal onset of CCHS, that is, in the first month of life. The European Central Hypoventilation Syndrome Consortium created an online patient registry from which 97 infants (44 females) with CCHS of neonatal onset and PHOX2B mutation from 10 countries were selected.

Roots and early routes of neuroendocrinology.

Carl C. Speidel (1919) and Ernst Scharrer (1928) were privileged witnesses of the encounter between neurons and hormones, a biological phenomenon that had been occurring in nature during millions of years of evolution, as Berta Scharrer started to unfold since 1935 on. The story of neurosecretion is intimately associated to that of the hypothalamus, such a "marvellous region", as Wolfgang Bargmann (1975) called it.

Efficacy and Tolerance of the Tampsec Vaginal Tampon for Treating Stress Urinary Incontinence. A Randomized Controlled Trial.

Introduction And Hypothesis: Stress urinary incontinence (SUI) is a highly prevalent condition in women. We hypothesized that the Tampsec™ vaginal tampon will be efficacious and well tolerated in its treatment.

Methods: This was a multicenter open-label parallel-group randomized control trial.

Choosing the right signaling pathway: hormone responses to Phytophthora cinnamomi during compatible and incompatible interactions with chestnut (Castanea spp.).

Ink disease caused by the hemibiotrophic root pathogen Phytophthora cinnamomi (Pc) is devastating for the European chestnut (Castanea sativa), unlike Asian chestnuts and interspecific hybrids which are resistant to Pc. The role that hormone responses play for Pc resistance remains little understood, especially regarding the temporal regulation of hormone responses. We explored the relationship between changes in tree health and physiology and alterations in leaf and root phytohormones and primary and secondary metabolites during compatible and incompatible Castanea spp.

Identifying metabolomic mediators of the physical activity and colorectal cancer relationship.

Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer (CRC). However, the mediating role of the circulating metabolome in this relationship remains unclear.

Methods: Targeted metabolomics data from 6,055 participants in the EPIC cohort were used to identify metabolites associated with PA and derive a metabolomic signature of PA levels.

Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study.

Background: Patients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life (HRQoL) and clinical outcome to immunotherapy. eHealth tools can aid patients with cancer in addressing issues, such as adverse events and psychosocial well-being, from various perspectives.

Objective: This study aimed to explore the effect of the Cancer Patients Better Life Experience (CAPABLE) system, accessed through a mobile app, on HRQoL compared with a matched historical control group receiving standard care.

Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex.

The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical inputs, but its synaptic organization in the human brain is largely unknown. We used volume electron microscopy to perform a 3D analysis of the microanatomical features of synapses in all layers of the medial EC (MEC) from the human brain.

Organophotoredox-Driven Three-Component Synthesis of β-Trifluoromethyl β-Amino Ketones†.

In this work, we present a photoredox three-component reaction that enables the synthesis of medicinally relevant β-trifluoromethyl β-amino ketones from a -trifluoroethylhydroxylamine derivative, styrenes and DMSO. Remarkably, fluoromethyl, difluoromethyl and pentafluoroethyl analogues are also accessed using the same reaction conditions. The mechanistic investigations, including radical trapping experiments, cyclic voltammetry, Stern-Volmer quenching studies and isotope labelling experiments support the photoinduced radical/polar crossover and Kornblum-type oxidation mechanisms.

Ru(II)-Based Multitopic Hosts for Fullerene Binding: Impact of the Anion in the Recognition Process.

The development of multitopic hosts for fullerene recognition based on nonplanar corannulene (CH) structures presents challenges, primarily due to the requirement for synergistic interactions with multiple units of this polycyclic aromatic hydrocarbon. Moreover, increasing the number of corannulene groups in a single chemical structure while avoiding the cost of increasing flexibility has been scarcely explored. Herein, we report the synthesis of a family of multitopic Ru(II)-polypyridyl complexes bearing up to six units of corannulene arranged by pairs, offering a total of three molecular tweezers.

Effect of a tailored exercise programme on kinematics and kinetic knee injury risk during different side-cutting.

Despite the high incidence of knee injuries reported in non-professional sports, the implementation of specific training programmes aimed at mitigating the kinematic and kinetic factors associated with these injuries remains limited. To determine the effects of a tailored exercise programme on kinematic and kinetic variables during side-cutting activities. Fifty-seven physically active participants were randomised into control group (CG; n: 28) that received no intervention, and an experimental group (EG; n: 29), that performed an individualised exercise programme that included a combination of strength, neuromuscular, proprioceptive, eccentric training and whole-body vibration (WBV) exercises.

The interplay between individual capacities and pair performance according to the experience in Acrobatic Gymnastics.

The interplay between individual capacities and group performance provides insights for different tasks and contexts. So far, little is known about the individual capacities of base and top gymnasts and mechanical efficiency during pair tasks of Acrobatic Gymnastics. This work aims to investigate: (1) the effect of the pair experience in the mechanical efficiency during a pair task; (2) the effect of the individual training experience in the gymnasts' individual capacities, and (3) the contribution of individual capacities and pair mechanical efficiency to the performance of a partner-assisted flight task.

Resisted sprint training with combined loads improve the maximum velocity in professional female soccer.

We analysed the long-term adaptations of resisted sprint training (RST) with combined loads on the performance and kinematics of the maximal velocity (MV). One team women's professional soccer players performed a six-week training programme with progressive sled loading from 20% to 80% of body mass. Pre-training, post-training and detraining measures were obtained for sprint times for 0-20 m, 20-30 m and 0-30 m, while step length (SL), step rate (SR), step velocity, trunk, hip, thigh, knee, shank ankle, foot and centre of mass (CoM) angles were digitised with an 18-point human model.