Untargeted metabolomics to relate changes produced by biocontrol agents against Aspergillus westerdijkiae and Penicillium nordicum in vitro on dry-cured ham.

Dry-cured ham is a highly appreciated meat product. During the ripening, moulds grow on its surface such as Penicillium nordicum and Aspergillus westerdijkiae producers of ochratoxin A (OTA). This mycotoxin poses a risk to consumers that must be controlled.

Unraveling atomic-scale mechanisms of GDP extraction catalyzed by SOS1 in KRAS-G12 and KRAS-D12 oncogenes.

The guanine exchange factor SOS1 plays a pivotal role in the positive feedback regulation of the KRAS signaling pathway. Recently, the regulation of KRAS-SOS1 interactions and KRAS downstream effector proteins has emerged as a key focus in the development of therapies targeting KRAS-driven cancers. However, the detailed dynamic mechanisms underlying SOS1-catalyzed GDP extraction and the impact of KRAS mutations remain largely unexplored.

Policies and strategies to control antimicrobial resistance in livestock production: A comparative analysis of national action plans in European Union Member States.

Policy strategies targeting imprudent antimicrobial use (AMU) in livestock farming have been established at the global and country levels, recognising the risks associated with antimicrobial resistance (AMR). This study evaluates the strategies addressing AMU and AMR in animal farms and the food supply chain in EU Member States using a multimethod approach. Our aim is to contribute to the debates surrounding the goals set by the EU Commission and the 'Strategic framework for collaboration on antimicrobial resistance: Together for One Health'.

Multi-omics profiling reveals altered mitochondrial metabolism in adipose tissue from patients with metabolic dysfunction-associated steatohepatitis.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe form steatohepatitis (MASH) contribute to rising morbidity and mortality rates. The storage of fat in humans is closely associated with these diseases' progression. Thus, adipose tissue metabolic homeostasis could be key in both the onset and progression of MASH.

Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial.

Background: The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe COVID-19.

Hospitalization cost estimates of respiratory syncytial virus and influenza infections in adults in Spain, 2016-2019.

Respiratory syncytial virus (RSV) is increasingly a recognized cause of severe respiratory infection among adults. This retrospective observational study compared the costs of RSV and influenza hospitalizations in adults aged ≥18 years admitted to the Spanish National Healthcare System between 2016 and 2019. Mean costs per hospitalization episode were compared using a multivariable log-gamma generalized linear model adjusted by age, risk group and calendar year.

Nanoencapsulation of vitamin B using chitosan-modified poly(lactic-co-glycolic acid) nanoparticles: Synthesis, characterization, and in vitro studies on simulated gastrointestinal stability and delivery.

Vitamin B, or riboflavin, is essential for maintaining healthy cellular metabolism and function. However, its light sensitivity, poor water solubility, and gastrointestinal barriers limit its storage, delivery, and absorption. Selecting suitable nanomaterials for encapsulating vitamin B is crucial to overcoming these challenges.

Early Improvement in Cardiac Function and Dyssynchrony After Physiological Upgrading in Pacing-Induced Cardiomyopathy.

Background: Interventricular dyssynchrony derived from the classic non-physiological stimulation (n-PS) of the right ventricle (RV) is a known cause of left ventricular dysfunction (LVDys).

Methods: This was a prospective descriptive single-center study. We analyzed patients who develop LVDys with n-PS, and the results after upgrading to conduction system pacing (CSP).

A Comparison between the Methodology of the Mainstream in (Neuro-)Psychology, Holzkamp's and Vygotsky's Approach.

The present paper treats the issue of methodological assumptions in mainstream neuropsychology and, as counter-concepts, in Vygotsky's approach and Holzkamp's critical psychology. The analysis identifies four main assumptions concerning the methodology of mainstream neuropsychology, which are contrasted with the positions of other approaches. The methodologies of the mainstream neuropsychology vs.

Diagnostic value of hemoglobin concentration in identifying Meckel's diverticulum in pediatric lower gastrointestinal bleeding.

Purpose: To assess the diagnostic performance of hemoglobin concentration for Meckel's diverticulum (MD) and evaluate if hemoglobin levels could be useful in the surgical decision-making process of children with lower gastrointestinal bleeding (LGIB).

Methods: Retrospective cohort study of children with LGIB attending the emergency department between 2011 and 2021. Episodes of LGIB were divided into two groups: MeckD (MD diagnosed by surgery) and non-MeckD.

Real-world experience of diagnosis, disability, and daily management in parents of children with different genetic developmental and epileptic encephalopathies: a qualitative study.

Purpose: This study describes the experience of parents of children with developmental and epileptic encephalopathies (DEE) and how the disease impacts their daily lives.

Materials And Methods: A descriptive qualitative study was conducted using purposeful sampling. Twenty-one parents of children with DEEs caused by SCN1A, KCNQ2, CDKL5, PCDH19, and GNAO1 variants were included.

An Atlas of Anatomical Variants of the Human Talus.

Anatomical variants can be used effectively to identify relationships between individuals in kinship analysis and they may be useful during surgical procedures. These procedures can be better implemented when the cause, appearance and location are understood. Clear representations and definitions of anatomical traits are necessary.

Outliers of Treatment Frequency in Retinal Vein Occlusion: 24-Month Comparative Analysis of Fight Retinal Blindness! Practitioners.

Background: We aimed to describe a 2-year outcome of eyes managed by practitioners benchmarked using a funnel plot by their frequency of treatment using vascular endothelial growth factor (VEGF) inhibitors for naive retinal vein occlusion (RVO).

Methods: A multicentre, international, observational study of 29 doctors in 12 countries managing 1110 eyes with RVO commencing VEGF inhibitors between 1 January 2012-2022 tracked in the Fight Retinal Blindness! registry.

Results: We identified 3 outlying 'intensive' practitioners (managing 350/1110 eyes [32%]), 22 'typical' practitioners (604/1110, [54%]) and 4 outlying 'relaxed' practitioners (156/1110, [14%]) with respective 24-month outcomes in Branch and Central RVO including the primary outcome, mean adjusted change in visual acuity (VA) in BRVO: +16.

Black soldier fly larvae: a one health approach to investigate gut, and organ health and meat quality response in slow-growing chickens.

Background: The inclusion of sustainable protein sources in poultry feed has become essential for improving animal welfare in livestock production. Black soldier fly larvae are a promising solution due to their high protein content and sustainable production. However, most research has focused on fast-growing poultry breeds, while the effects on native breeds, such as the Bianca di Saluzzo, are less explored.

Patient satisfaction and safety in the administration of sedation by nursing staff in the digestive endoscopy service: a cross-sectional study.

Background: The satisfaction of patients with sedation by nursing staff is an issue of interest for the quality of health care, influencing the recovery and well-being of patients as well as their confidence in and adherence to treatment. One of the most frequently performed diagnostic and therapeutic tests requiring sedation are digestive endoscopies, so it would be interesting to study satisfaction in these services.

Aim: To determine the level of patient satisfaction and safety with sedation via digestive endoscopies by nurses.

Sensory neuropathy in patients with Pompe disease: a case series in Iran.

Background: Pompe disease is a glycogen storage disease primarily affecting striated muscles. Despite its main manifestation in muscles, patients with Pompe disease may exhibit non-muscle symptoms, such as hearing loss, suggesting potential involvement of sensory organs or the nervous system due to glycogen accumulation.

Aims: This study aimed to evaluate the presence of concomitant small and large fiber neuropathy in patients with Pompe disease.

Microalgae for bioremediation: advances, challenges, and public perception on genetic engineering.

The increase in the global population and industrial activities has led to an extensive use of water, the release of wastewater, and overall contamination of the environment. To address these issues, efficient treatment methods have been developed to decrease wastewater nutrient content and contaminants. Microalgae are a promising tool as a sustainable alternative to traditional wastewater treatment.

RNA profiles differ between small and large extracellular vesicle subsets isolated from porcine seminal plasma.

Background: Extracellular vesicles (EVs) are essential for cell-to-cell communication because they transport functionally active molecules, including proteins, RNA, and lipids, from secretory cells to nearby or distant target cells. Seminal plasma contains a large number of EVs (sEVs) that are phenotypically heterogeneous. The aim of the present study was to identify the RNA species contained in two subsets of porcine sEVs of different sizes, namely small sEVs (S-sEVs) and large sEVs (L-sEVs).

Adaptive or non-adaptive? Cranial evolution in a radiation of miniaturized day geckos.

Lygodactylus geckos represent a well-documented radiation of miniaturized lizards with diverse life-history traits that are widely distributed in Africa, Madagascar, and South America. The group has diversified into numerous species with high levels of morphological similarity. The evolutionary processes underlying such diversification remain enigmatic, because species live in different ecological biomes, ecoregions and microhabitats, while suggesting strikingly high levels of homoplasy.

Measurement distance effects on [Formula: see text]-symmetric Taylor patterns with optimal transition integer [Formula: see text] and with reduced inner sidelobes.

The following paper presents the findings of a study conducted on the distances at which the field generated by a ϕ-symmetric circular Taylor aperture distribution can be classified as far-field, and also the efficiency across various study parameters. The [Formula: see text] transition integers that produce a monotonic distribution, which have been traditionally used and analyzed, are compared with those that yield a peaked distribution, and offer greater efficiency. Additionally, modified circular Taylor [Formula: see text] distributions featuring synthesized patterns with one or two depressed inner sidelobes, which have not been previously explored, are also examined.

Human brain aging is associated with dysregulation of cell type epigenetic identity.

Significant links between aging and DNA methylation are emerging from recent studies. On the one hand, DNA methylation undergoes changes with age, a process termed as epigenetic drift. On the other hand, DNA methylation serves as a readily accessible and accurate biomarker for aging.

Automated MRI pituitary structured reporting from free-text using a fine-tuned Llama model: a feasibility study.

Background And Objective: Structured reports in radiology have demonstrated substantial advantages over unstructured ones. However, the transition from unstructured to structured reporting can face challenges, as experienced radiologists worry about the potential loss of valuable information. In this study, we fine-tuned the Llama 2 model capable of generating structured pituitary MRI reports from unstructured reports.