761,361 results match your criteria: "Spain; Institute of Research Sant Joan de Deu[Affiliation]"
Front Oncol
January 2025
Facultat de Psicología, Departamento de Psicología Social, Instituto de Investigación en Psicología de los RRHH, Desarrollo Organizacional y Calidad de Vida Laboral (IDOCAL), Universitat de València, Valencia, Spain.
Introduction: The problems related to nutrition generate great concern in palliative cancer patients and their caregivers. Literature has analyzed the psychological and social problems that nutrition causes. From patient-centered orientation, there are protocols for nutritional care.
View Article and Find Full Text PDFBiofilm
December 2024
Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Biodegradable polymeric coatings are being explored as a preventive strategy for orthopaedic device-related infection. In this study, titanium surfaces (Ti) were coated with poly-D,L-lactide (PDLLA, (P)), polyethylene-glycol poly-D,L-lactide PEGylated-PDLLA, (PP20)), or multi-layered PEGylated-PDLLA (M), with or without 1 % silver sulfadiazine. The aim was to evaluate their cytocompatibility, resistance to biofilm formation, and their potential to enhance the susceptibility of any biofilm formed to antibiotics.
View Article and Find Full Text PDFNatl J Maxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, Hospital Universitario La Paz, Paseo de la Castellana, Madrid, Spain.
The anatomical location of certain lesions can be a difficulty when locating them intraoperatively. The use of surgical navigation allows anatomical structures to be located with great precision. However, there are technical difficulties with its use in mandibular surgery.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, Cáceres, Spain.
Front Pharmacol
January 2025
Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland.
Paclitaxel (PTX) is a commonly used chemotherapeutic drug, however, one of its major adverse effects is chronic neuropathic pain, with the incidence being higher in women than in men. The neurobiological mechanisms behind this sex difference are still largely unclear, and the endocannabinoid system, which exhibits sexual dimorphism and plays a key role in pain regulation, is a promising area for further studies. The present study aimed to characterise pain-, cognition-, anxiety-, and depression-related behaviours in male and female rats following PTX administration, and associated alterations in the endocannabinoid system.
View Article and Find Full Text PDFFungal Syst Evol
December 2024
Westerdijk Fungal Biodiversity Institute, P.O. Box 85167, 3508 AD Utrecht, The Netherlands.
Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .
View Article and Find Full Text PDFJ Cogn
January 2025
Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium.
Rapidly learning new tasks, such as using new technology or playing a new game, is ubiquitous in our daily lives. Previous studies suggest that our brain relies on different networks for rapid task learning versus retrieving known tasks from memory, and behavioral studies have shown that novel versus practiced tasks may rely on different task configuration processes. Here, we investigated whether explicitly informing about the novelty of an incoming task would help participants prepare for different task configuration processes, such as pre-adjusting working memory gating functions.
View Article and Find Full Text PDFFront Public Health
January 2025
Department of Social Medicine and Epidemiology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Introduction: Due to the rapid aging of the global population, new approaches are required to improve the quality of life of older people and to reduce healthcare system expenditures. One of the approaches that can be used is value-based healthcare. This article describes a value-based solution for older people who have suffered a myocardial infarction.
View Article and Find Full Text PDFBiophys Rev
December 2024
Department of Optics, Pharmacology and Anatomy, University of Alicante, San Vicente del Raspeig, Spain.
In recent decades, research on mechanotransduction has advanced considerably, focusing on the effects of audible acoustic waves (AAWs) and low-vibration stimulation (LVS), which has propelled the field of sonobiology forward. Taken together, the current evidence demonstrates the influence of these biosignals on key cellular processes, such as growth, differentiation and migration in mammalian cells, emphasizing the determining role of specific physical parameters during stimulation, such as frequency, sound pressure level/amplitude and exposure time. These mechanical waves interact with various cellular elements, including ion channels, primary cilia, cell-cell adhesion receptors, cell-matrix and extracellular matrix proteins, and focal adhesion complexes.
View Article and Find Full Text PDFFarm Comunitarios
January 2025
Farmacéutica, Colegio Oficial de Farmacéuticos de Álava España.
Introduction: The medicines aid kits revision services is a Clinical Professional Pharmacy Service that aims to increase patients' knowledge about their medication, (What it is for, how to take it, how to preserve…). It also promotes proper management of expired and/or unused medicines, (disposal at punto SIGRE in pharmacies) to reduce their environmental impact.
Objective: To review the medicines, medical devices, and/or self-care products that the patient has at home, to record any incidents detected, and any pharmaceutical interventions carried out.
Chem Sci
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China
Lytic polysaccharide monooxygenases (LPMOs) are a unique group of monocopper enzymes that exhibit remarkable ability to catalyze the oxidative cleavage of recalcitrant carbohydrate substrates, such as cellulose and chitin, by utilizing O or HO as the oxygen source. One of the key challenges in understanding the catalytic mechanism of LPMOs lies in deciphering how they activate dioxygen using diverse reductants. To shed light on this intricate process, we conducted in-depth investigations using quantum mechanical/molecular mechanical (QM/MM) metadynamics simulations, molecular dynamics (MD) simulations, and density functional theory (DFT) calculations.
View Article and Find Full Text PDFRSC Med Chem
December 2024
Research Group of Organic Chemistry, Departments of Bioengineering Sciences and Chemistry, Vrije Universiteit Brussel Brussels Belgium
A peptide segment that is 10 residues long at the C-terminal (CT) region of Cx43 is known to be involved in interactions, both with the Cx43 protein itself and with other proteins, that result in hemichannel (HC) activity regulation. Previously reported mimetic peptides based on this region (, , ) have been revealed to be promising therapeutic agents in the context of cardiovascular diseases. In this work, novel approaches, such as C- and N-terminal modification and cyclization, to improve the proteolytic stability and bioavailability of the peptide are presented.
View Article and Find Full Text PDFJ Ultrason
December 2024
Faculty of Exercise Physiology, Department of Kinesiology and Sports Sciences, University of Miami, Coral Gables, United States.
Aim: The Nordic hamstring curl appears effective in reducing the incidence of injury in physically active young adults, likely through its capacity as an eccentric exercise to increase muscle stiffness. Although eccentric exercises have been shown to increase muscle stiffness, medium- and long-term Nordic hamstring curl training programs have not demonstrated an effect on muscle stiffness. This study examined the acute effects of a single session of Nordic hamstring curls on the stiffness of the biceps femoris, semitendinosus, and semimembranosus muscles using ultrasound shear wave elastography, an accepted method for measuring passive muscle stiffness.
View Article and Find Full Text PDFEur Heart J Case Rep
January 2025
Department of Cardiology, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 2, 18014 Granada, Spain.
ACS Omega
January 2025
Centro de Investigación en Materiales Avanzados, S.C. (CIMAV Subsede Monterrey), Alianza Norte 202, Parque de Investigación e Innovación Tecnológica, C.P. 66628 Apodaca, Nuevo León, Mexico.
Thermal atomic layer deposition (TALD) and plasma atomic layer deposition (PALD) were used for producing thin NiO films from nickel(II) acetylacetonate Ni(acac), employing different oxidizing agents (deionized water HO, ozone O, and molecular oxygen O). The films were deposited at 300 °C (TALD) and 220 °C (PALD) over glass substrates; their physical and chemical properties were considerably influenced by the choice of oxidizing agents. In particular, ALD(HO) samples had a low growth per cycle (GPC) and a high concentration of defects.
View Article and Find Full Text PDFACS Omega
January 2025
CIMUS Biomedical Research Institute & Department of Medical Sciences, University of Santiago de Compostela-IDIS, Santiago de Compostela 15782, Spain.
Scrapie is a prion disease of sheep and goats. Prions (PrP) replicate by inducing a natively expressed protein (PrP) to refold into the prion conformation. PrP and PrP contain a disproportionately large number of methionines.
View Article and Find Full Text PDFESC Heart Fail
January 2025
Department of Cardiology, Pulmonology, and Intensive Care Medicine, Center for Molecular Medicine Cologne (CMMC), Cologne Cardiovascular Research Center (CCRC), Medical Faculty, University of Cologne, Cologne, Germany.
Aims: Despite receiving guideline-directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH-LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long-acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. In a phase 1b study conducted in patients with HF, AZD3427 demonstrated a favourable safety and pharmacokinetic profile.
View Article and Find Full Text PDFDeath Stud
January 2025
PhD Program in Medical and Pharmaceutical Sciences, Development and Quality of Life, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
This qualitative study addresses a gap in knowledge regarding men's experience of the grieving process. Our limited understanding of the topic hinders the development of targeted support services. The study analyzes the meanings of continuing bonds for bereaved men in Costa Rica.
View Article and Find Full Text PDFEuroIntervention
January 2025
LAKUMED Hospital Landshut-Achdorf, Medizinische Kinik I, Landshut, Germany.
Chem Res Toxicol
January 2025
Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-900 São Paulo, SP, Brazil.
Acrylonitrile-butadiene-styrene (ABS) is a thermoplastic copolymer commonly used in the electronics, automotive, and construction industries. In the aquatic environment, the formation of microplastics from larger-sized plastic waste occurs naturally, induced by physical, chemical, and biological processes that promote the aging of these particles. Here, we investigated the interactions between the freshwater amphipod and ABS microplastics (10-20 μm) (pristine and after accelerated aging) over 7 days of exposure.
View Article and Find Full Text PDFJBI Evid Synth
January 2025
Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Objective: The objective of this scoping review is to develop a list of items for potential inclusion in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) reporting guidelines for network meta-analysis (NMA), scoping reviews (ScRs), and rapid reviews (RRs).
Introduction: The PRISMA extensions for NMA and ScRs were published in 2015 and 2018. However, since then, their methodologies and innovations, including automation, have evolved.
Anal Chem
January 2025
Departamento de Química Física, Facultad de Química, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Murcia 30100, Spain.
Electrochemistry in confined environments, that is, involving experimental configurations with spatial restrictions that affect the overall mass transport, is becoming a very attractive way of carrying out electroanalytical measurements for sensing, especially for the so-called thin-layer (TL) configuration, which ideally allows the complete conversion of the analytes under study in small volumes and short times. To improve the understanding of this kind of situation, general expressions for the current-potential-time and charge-potential-time responses of charge transfer processes taking place under finite diffusion conditions with two different configurations (no mass renovation, bounded diffusion; and effective mass renovation, unbounded diffusion) are discussed in this work. By using these expressions, it is possible to establish accurate limits for the attainment of TL conditions and to conclude that for bounded conditions, the charge is a more adequate quantity for electroanalytical purposes.
View Article and Find Full Text PDFAsian Spine J
January 2025
Department of Orthopaedic Surgery and Traumatology, Hospital San Rafael, A Coruña, Spain.
Minimally invasive spine surgery (MIS) has shown promising results, and endoscopic spine surgery has emerged as a less invasive approach. Although studies have examined the effectiveness of endoscopic surgery for spinal stenosis, no meta-analyses have focused on multilevel cases. This meta-analysis aimed to evaluate the efficacy and safety of uniportal and biportal endoscopy in patients with multilevel spinal stenosis.
View Article and Find Full Text PDFNeuroscientist
January 2025
Neurology Service, Lille Catholic Institute Hospital Group, (Groupe Hospitalier de l'Institut Catholique de Lille), GHICL, Lomme cedex, France.
The legacy of Santiago Ramón y Cajal, Spain's first Nobel laureate neuroscientist recognized as the founding father of modern neuroscience, is to be preserved in a new museum in Madrid: the National Museum of Natural Sciences (MNCN), one of the most important scientific research institutes in the country sciences in the scope of natural sciences of the Spanish National Research Council. For a boy who dreamed of being an artist but started his career apprenticed to first a barber and then a cobbler, Santiago Ramón y Cajal made a distinguished mark in science. One of Cajal's most important contributions to our understanding of the brain was his discovery of the direction of the information flow within neurons and in neural circuits, which he called the "dynamic polarization law," without a doubt the founding principle of neurosciences.
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