Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches.

The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers.

Value of ultrasound-assessed dactylitis in the early diagnosis of psoriatic arthritis.

Purpose: The primary objective of this prospective, longitudinal, observational, single-centre study was to evaluate the association between ultrasound-assessed lesions of dactylitis and the diagnosis of psoriatic arthritis (PsA) in patients with psoriasis (PsO) and hand arthralgia.

Methods: We included adult patients diagnosed with PsO with hand arthralgia, with or without other musculoskeletal complaints. They were clinically assessed at baseline, 6 and 12 months by a rheumatologist blinded to the ultrasound findings.

Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co-pathology.

Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta-amyloid peptide (Aβ), has a prion-like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3-4 decades.

Understanding the pathways to text generation: A longitudinal study on executive functions, oral language, and transcription skills from kindergarten to first grade.

This longitudinal study explored the contribution of transcription skills, oral language abilities, and executive functions in kindergarten to written production in grade 1 among Spanish-speaking children (N = 191) through structural equation modeling (SEM). Three dimentions of written production were assessed, including productivity, quality, and syntactic complexity. Accordingly, three SEM models were tested to explore these relationships, and the estimated models for each endogenous variable demonstrated good fit.

Qualitative evaluation of survey questions to assess treatment preference for daily oral or long‑acting injectable antiretroviral therapy among people living with HIV.

Treatment of HIV has historically required taking daily oral antiretroviral therapy (ART). A recent alternative to daily oral ART is long-acting injectable ART with cabotegravir plus rilpivirine, administered monthly or every 2 months. The purpose of this qualitative study was to evaluate the concept relevance and interpretability of five previously developed questions: one treatment preference question and four questions designed to assess how the emotional burden associated with HIV treatment impacts treatment preferences.

Values associated with Nordic Walking: An international cross-sectional survey among individuals practicing walking with poles.

Introduction: The article is devoted to the sociological exploration of the social phenomenon that Nordic Walking has become in Europe and worldwide over the recent decades.

Aim: It is based on the results of original international sociological research study on the issue of sociodemographic profiles of Nordic Walkers in the context of the values associated with this sports activity.

Methods: A cross-sectional quantitative study with convenience sampling study was performed among 416 Poles, 132 Europeans from 11 countries (Germany, the UK, Spain, France, Italy, Portugal, Ireland, Denmark, Austria, Sweden, and Norway), and 212 participants from 5 non-European countries (the USA, Canada, Australia, New Zealand, and Japan).

Gendered dimension of chronic pain patients with low and middle income: A text mining analysis.

Methods: This is a mixed-method study using individual interviews (duration between 40-60 minutes) of 181 CNCP patients (71% females) in a tertiary Pain Care Unit, and applying the text mining methodology. Incomes (low or middle) and gender roles (productive vs. reproductive)".

Photoinduced Reductive C-O Couplings from Unsymmetrical Bis-Cyclometalated Pt(IV) Dicarboxylato Complexes.

Unsymmetrical bis-cyclometalated dicarboxylato complexes (-6-32)-[Pt(tpy)(OCR)] [tpy = cyclometalated 2-(-tolyl)pyridine, R = -Bu (), Me (), Ph (), CF ()], are obtained from the reaction of -[Pt(tpy)] with the appropriate PhI(OCR) reagent. Treatment of complexes of this type with different carboxylates (R'CO) results in the formation of mixed-carboxylato derivatives, namely (-6-43)-[Pt(tpy)(OCMe)(OCR')] [R' = -Bu (), CF (), Ph ()], (-6-34)-[Pt(tpy)(OCCF)(OCR')] [R' = -Bu (), Me (), Ph ()], and (-6-34)-[Pt(tpy)(OC--Bu)(OCMe)] (). Irradiation of - and - with UV light (365 nm) in MeCN gives 5-methyl-2-(2-pyridyl)phenyl pivalate (), 5-methyl-2-(2-pyridyl)phenyl acetate () or 5-methyl-2-(2-pyridyl)phenyl benzoate () as the major photoproduct from most complexes, resulting from a reductive C-O coupling between a tpy ligand and a carboxylato ligand.

CAECENET: An automatic system processing photometer and ceilometer data from different networks to provide columnar and vertically-resolved aerosol properties.

This work introduces CAECENET, a new system capable of automatically retrieving columnar and vertically-resolved aerosol properties running the GRASP (Generalized Retrieval of Atmosphere and Surface Properties) algorithm using sun-sky photometer (aerosol optical depth, AOD; and sky radiance measurements) and ceilometer (range corrected signal; RCS) data as input. This method, so called GRASPpac, is implemented in CAECENET, which assimilates sun-sky photometers data from CÆLIS database and ceilometer data from ICENET database (Iberian Ceilometer Network). CAECENET allows for continuous and near-real-time monitoring of both vertical and columnar aerosol properties.

Barriers to social participation for people with disabilities in NTD-endemic areas of Benin and Côte d'Ivoire: Assessing scope and associated factors.

People with disabilities (PWDs) due to neglected tropical diseases (NTDs) or other causes experience restrictions on social participation (RSPs). This study aimed to investigate the magnitude of these restrictions and associated factors in NTD-endemic communities in Benin and Côte d'Ivoire. This cross-sectional quantitative and qualitative study was conducted from 2021 to 2022 among 841 people with disabilities (PWDs) and 90 community members and stakeholders.

Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders.

Background: Pain in people with cerebral palsy (CP) has been classically underestimated and poorly treated, particularly in individuals with impaired communication skills.

Objective: To analyze changes in different salivary metabolites and pain behavior scales after a painful procedure in adults with CP and adults with typical development.

Methods: Salivary levels of sTNF-α, sIgA, Cortisol, FRAP, ADA and Alpha Amylase, as well as 3 observational pain scales (Wong-Baker, Non-Communicating Adults Pain Checklist and Facial Action Coding System) were assessed before and after an intramuscular injection in 30 Individuals with CP and 30 healthy controls.

Effects of intramuscular administration of Platelet-Rich Plasma on denervated muscle after peripheral nerve injury.

Purpose: After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and.

Retinoblastoma and beyond: pediatric orbital mass lesions.

Various space occupying lesions can arise in the orbit, ranging from developmental anomalies to malignancies, and many of the diseases occurring in children are different from the pathologies in the adult population. As the clinical presentation is frequently nonspecific, radiologic evaluation is essential for lesion detection and characterization as well as patient management. While orbital masses may in some cases involve multiple compartments, a simple compartmental approach is the key for the diagnosis on imaging studies, and MRI is the modality of choice.

The impact of uterine cavity structural features on reproductive outcomes in T-shaped uterine malformation.

Objectives: Despite advancements in modern medicine, the effectiveness of in vitro fertilization (IVF) remains low. This study aimed to assess the impact of specific features of T-shaped uterine cavity malformation and its intermediate forms on reproductive function and the effectiveness of assisted reproductive technology (ART), particularly on IVF results and pregnancy outcomes.

Methods: A prospective cohort study included 388 somatically healthy patients undergoing 3D ultrasound (US) examination of the uterine cavity before embryonic transfer for IVF treatment.

Point-of-care additive manufacturing: state of the art and adoption in Spanish hospitals during pre to post COVID-19 era.

Background: 3D technologies [Virtual and Augmented 3D planning, 3D printing (3DP), Additive Manufacturing (AM)] are rapidly being adopted in the healthcare sector, demonstrating their relevance in personalized medicine and the rapid development of medical devices. The study's purpose was to understand the state and evolution of 3DP/AM technologies at the Point-of-Care (PoC), its adoption, organization and process in Spanish hospitals and to understand and compare the evolution of the models, clinical applications, and challenges in utilizing the technology during the COVID-19 pandemic and beyond.

Methods: This was a questionnaire-based qualitative and longitudinal study.

ASYMPTOMATIC INFLAMMATORY BOWEL DISEASE DIAGNOSED DURING COLORECTAL CANCER POPULATION SCREENING IN CATALONIA: CHARACTERISTICS AND NATURAL HISTORY.

Introduction: Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of IBD patients with no symptoms.

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.

Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal.

Leaf traits and insect herbivory levels in two Mediterranean oaks and their hybrids through contrasting environmental gradients.

Insect herbivory has attracted enormous attention from researchers due to its effects on plant fitness. However, there remain questions such as what are the most important leaf traits that determine consumption levels, whether there are latitudinal gradients in herbivore pressure, or whether there are differences in susceptibility between hybrids and their parental species. In this work we address all these issues in two species of Mediterranean Quercus (Q.

The Use of the Nitroblue Tetrazolium Test in Blood Granulocytes for Discriminating Bacterial and Non-Bacterial Neutrophilic Dermatitis.

This study aimed to evaluate differences in the production of reactive oxygen species (ROS) by peripheral blood neutrophils in healthy dogs, dogs with superficial pyoderma, and dogs with sterile neutrophilic dermatitis using the nitroblue tetrazolium (NBT) reduction test. Additionally, the study assessed the potential of the NBT reduction test as a diagnostic tool to differentiate between these clinical conditions. A total of 28 dogs were divided into three groups: healthy (n = 10), superficial pyoderma (n = 10), and sterile neutrophilic dermatitis (n = 8).

Evolution of Sow Productivity and Evaluation Parameters: Spanish Farms as a Benchmark.

This study examines the global evolution of sow productivity, with a particular focus on Spain. The analysis is based on key performance metrics such as piglets weaned per sow per year (PWSY), prolificacy, and pre-weaning mortality, utilizing data from literature reviews, the InterPIG, and BDporc databases. Globally, significant advancements in genetic selection and management practices have led to productivity increases across major pig-producing countries, with notable improvements in prolificacy.

Effect of a Broiler-Specific Light Spectrum on Growth Performance and Adrenocortical Activity in Chickens: A Pilot Study on a Commercial Farm.

This study evaluated the effect of a broiler-specific light spectrum on productive performance corticosterone (fCC) and androgen dehydroepiandrosterone (fDHEA) concentrations in feathers, and glucocorticoid (GCMs) and androgen (AMs) metabolites in droppings of broilers. Two groups of female Ross 308 broilers were reared under white LED (WL, n = 9000) and broiler-specific LED (BSL, n = 9000) lights. The body weight (BW) of 150 randomly selected animals/groups was measured weekly.

Study of the Normal Crested Porcupine () Nasal Cavity and Paranasal Sinuses by Cross-Sectional Anatomy and Computed Tomography.

This study utilized CT imaging to investigate the rostral part of the head of the crested porcupine's head. By combining CT images with anatomical cross-sections, we have provided a detailed description of the structures in this area. This information could be useful for diagnosing disorders and improving their treatment in the nasal cavity and paranasal sinuses of crested porcupines.

Echocardiographic Changes in Dogs with Stage B2 Myxomatous Mitral Valve Disease Treated with Pimobendan Monotherapy.

The present study aimed to evaluate the effects of chronic pimobendan monotherapy on cardiac size in dogs with stage B2 myxomatous mitral valve disease (MMVD). Data from 31 dogs diagnosed with MMVD and cardiomegaly (LA/Ao ≥ 1.6 and LVIDdn ≥ 1.