On 'the Politics of Repair Beyond Repair': Radical Democracy and the Right to Repair Movement.

This paper analyses the right to repair (R2R) movement through the lens of radical democracy, elucidating the opportunities and limitations for advancing a democratic repair ethics against a backdrop of power imbalances and vested interests. We commence our analysis by exploring broader political-economic trends, demonstrating that Original Equipment Manufacturers (OEMs) are increasingly shifting towards asset-based repair strategies. In this landscape, hegemony is preserved not solely through deterrence tactics like planned obsolescence but also by conceding repairability while monopolizing repair and maintenance services.

Mixed viral infections (Rotavirus, Herpesvirus and others) in European wild rabbits.

Infectious viral pathogens significantly impact wild Leporidae populations, particularly , which was listed as 'Endangered' in 2019. Myxomatosis and rabbit haemorrhagic disease are major contributors to severe epizootics with limited long-lasting immunity. This study expanded beyond these well-documented viruses to include a broader spectrum of viruses in 36 wild rabbit carcasses () collected from the field in 2018, 2019, 2021 and 2024, and 32 wild rabbits hunted in 2017/2018.

E74-like ETS transcription factor 3 expression and regulation in human intervertebral disc.

Background: Intervertebral disc degeneration (IVDD) is one of the main causes of chronic low back pain. The degenerative process is often initiated by an imbalance between catabolic and anabolic pathways. Despite the large socio-economic impact, the initiation and progress of disc degeneration are poorly understood.

KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis.

Oncolytic adenoviral therapy is a promising approach for pancreatic cancer treatment. However, the limited capacity of murine cells to produce infectious viral progeny precludes the full evaluation of the virotherapy in a suitable immunocompetent mouse model. Here, we report that the murine KPC-I cell line, established from pancreatic tumors developed in ; ; mice, is susceptible to adenoviral replication and generates a progeny of infective virions similar to those from infected human A549 cells.

Exploring the therapeutic potential of glucagon-like peptide 1 agonists in metabolic disorders.

This article comments on the work by Soresi and Giannitrapani. The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease (MASLD) is the use of glucagon-like peptide 1 receptor agonists, especially when used in combination therapy. However, despite their notable efficacy, these drugs were not initially designed to target MASLD directly.

Delirium and Cognitive Screening in National Hip Fracture Registries: Scoping Review Protocol.

Background: Delirium and cognitive impairment are common in hip fracture populations and are associated with significant adverse patient outcomes. National hip fracture registries facilitate improvements in patient outcomes and care quality, such as reduced mortality and the development of specialist multidisciplinary services. However, there is substantial variation in the data collected and reported in relation to delirium and cognition, which impedes international comparison and may reduce quality of care.

Naxos Disease and Related Cardio-Cutaneous Syndromes.

Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified causative variant was in the gene encoding the desmosomal protein plakoglobin. Naxos disease exhibits fibro-fatty myocardial replacement with immunohistological abnormalities in cardiac protein and signaling pathways, highlighting the role of inflammation and potential anti-inflammatory treatments.

Endurance training and pyruvate dehydrogenase kinase 4 (PDK4) inhibition combination is superior to each one alone in attenuating hyperketonemia/ketoacidosis in diabetic rats.

Objectives: While ketone bodies are not the main heart fuel, exercise may increase their uptake. Objectives: This study aimed to investigate the effect of 6-week endurance training and Pyruvate dehydrogenase kinase 4 )PDK4( inhibition on ketone bodies metabolism in the heart of diabetic rats with emphasis on the role of Peroxisome proliferator-activated receptor-gamma coactivator PGC-1alpha (PGC-1α).

Materials And Methods: Sixty male Wistar rats were divided into eight groups: healthy control group (CONT), endurance training group (TRA), diabetic group (DM), DM + EX group, Dichloroacetate (DCA) group, DM + DCA group, TRA + DCA group, and DM + TRA + DCA group.

Is an oritavancin catheter lock solution active against biofilms of staphylococci and enterococci?

Background: Oritavancin (ORT) is a new single-dose lipoglycopeptide showing activity against staphylococci and vancomycin-resistant enterococci. However, there is no data regarding its potential use as a catheter lock solution are scarce. We constructed an model to analyze the efficacy and stability of an ORT lock solution against the biofilm of staphylococci and enterococci over 7 days at 37 °C.

The impact of preoperative venous thromboembolism on patients undergoing TURBT: Perioperative outcomes and healthcare costs from US insurance claims data.

Objectives: To assess the impact of a positive history of venous thromboembolism (VTE) on perioperative outcomes, including length of in-hospital stay, readmission rates, 90-day postoperative complications, and healthcare costs in bladder cancer (BCa) patients undergoing transurethral resection of bladder tumour (TURBT) in the United States.

Patients And Methods: Patients aged ≥18 years with a BCa diagnosis undergoing TURBT were identified in the Merative® Marketscan® Research de-identified databases between 2007 and 2021. Multivariable logistic regression adjusted by relevant perioperative confounders was used to investigate the association between diagnosis of VTE before TURBT and 90-day complication rates, new postoperative VTE events, re-hospitalization, and total hospital expenditures (2021 US dollars).

The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer: Results from the IDENTIFY study.

Objectives: To assess the contemporary malignancy rate in isolated de novo red patches in the bladder and associated risk factors for better selection of red patch biopsy.

Patients: Patients from the IDENTIFY dataset; Patients referred to secondary care with suspected urinary tract cancer and found to have isolated de novo red patches on cystoscopy.

Methods: We reported the unadjusted cancer prevalence in isolated de novo red patches that were biopsied; multivariable logistic regression was used to explore cancer-associated risk factors including age, sex, smoking, type of haematuria, LUTS, UTIs and a suspicious-looking red patch (as reported by the cystoscopist).

SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols.

Unlabelled: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. The SPIRIT statement, designed for trial protocol content, does not adequately cover the distinctive features of EPDF trials. Recent findings indicate that the protocol contents in past EPDF trials frequently lacked completeness and clarity.

Unraveling the Role of Water in Isothermal Methanol Partial Oxidation to Methyl Formate on Gold: A Combined Experimental and Computational Study.

Since water is both a product and a common reactant impurity in the (partial) methanol oxidation to methyl formate (MeFo) on gold, its effect on the isothermal selectivity to methyl formate was investigated under well-defined single-collision conditions employing pulsed molecular beam experiments and in situ IRAS measurements. Both a flat Au(111) and a stepped Au(332) surface were used as model catalysts to elucidate how water affects the reactivity of low-coordinated step sites as compared to (111) terrace sites employing a range of reaction conditions. The interactions of water with methanol/methoxy as well as with oxygen species are addressed.

'As if the soul returns to the body': affect, stuckedness, and (in)voluntary return to Nicaragua from Spain.

This article attends to the emotional resonances of 'stuckedness' and (in)voluntary return as experienced by Nicaraguan migrants stranded in Spain during the COVID-19 pandemic. Feeling both figuratively and literally trapped in a context of cascading lockdowns, border closures, and travel restrictions, many viewed Spain's Assisted Voluntary Return and Reintegration (AVRR) programme as offering a choice to 'freely' depart Spain - a way to simultaneously leave their distressing circumstances behind while returning to the comfort of 'home' and family. Building on recent literature that challenges the basis for participation in such programmes as founded on free, voluntary, and individual decisions, this article contends that, for some, the act of 'choosing' to return generates a profound and unexpected emotional response.

Genomic evaluation of phenotypic antibiotic susceptibility patterns as a surrogate for MRSA relatedness and putative transmission during outbreak investigations.

Antibiograms have been used during outbreak investigations for decades as a surrogate for genetic relatedness of Methicillin-resistant (MRSA). In this study, we evaluate the accuracy of antibiograms in detecting transmission, using genomic epidemiology as the reference standard. We analysed epidemiological and genomic data from 1,465 patients and 1,465 MRSA isolates collected at a single clinical microbiology laboratory in the United Kingdom over a one-year period.

Aqueous extracts of and as promising sources of antibiofilm compounds against mucoid and small colony variants of and .

Bacterial biofilms formed by and pose significant challenges in treating cystic fibrosis (CF) airway infections due to their resistance to antibiotics. New therapeutic approaches are urgently needed to treat these chronic infections. This study aimed to investigate the antibiofilm potential of various plant extracts, specifically targeting mucoid and small colony variants of and and strains.

Is it possible to talk about violence climate in grassroots sport? A study on the psychosocial adaptations of young athletes.

Introduction: There is a need for greater scientific attention to research on violence (e.g., insults, intimidation, beatings) in contexts where such behaviors are prevalent.

Insulin, IGF-I, and lactoferrin concentrations and yields and their associations with other components within colostrum, transition, and whole milk of primiparous and multiparous Holstein cattle.

The primary objective of the study was to characterize concentrations and yields of lactoferrin (LF), insulin, and IGF-I in colostrum, transition milk (TM), and whole milk (WM) of multiparous (MP) and primiparous (PP) cows. A secondary objective was to determine associations between colostrum and TM components (fat, protein, lactose), IgG, and bioactive compounds (oligosaccharides, LF, insulin, IGF-I; defined as compounds present in micro quantities that stimulate physiological responses systemically or locally within the neonate). Holstein cows (10 MP and 10 PP) were assigned to the study at calving and colostrum was collected 5.

Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats.

Millions of patients and their caretakers live and deal with the devastating consequences of spinal cord injury (SCI) worldwide. Despite outstanding advances in the field to both understand and tackle these pathologies, a cure for SCI patients, with their peculiar characteristics, is still a mirage. One of the most promising therapeutic strategies to date for these patients involves the use of epidural electrical stimulation.

Epidemiological, economic and humanistic burden of cervical intraepithelial neoplasia in Europe: A systematic literature review.

Introduction: High-grade cervical intraepithelial neoplasia (CIN) is a premalignant lesion of the cervix caused by persistent human papillomavirus (HPV) infection, which can lead to cervical cancer. Despite ongoing primary prevention efforts, considerable burden of illness remains. This study assessed the epidemiological, economic, and humanistic burden associated with high-grade CIN among adult women in Europe.

Insights into the electroactive impact of magnetic nanostructures in PVDF composites small-angle neutron scattering.

Poly(vinylidene fluoride) (PVDF) is technologically relevant due to its thermal stability; chemical, mechanical and radiation resistance; transparency; biocompatibility; and ease of processing. Several of those applications are related to its high electroactivity, for which the β-phase of the polymer is its most renowned protagonist. In this context, extensive research has been conducted on the crystallization of PVDF in the β-phase, when processed from melt and from solution.

EMDR Interventions in Refugees and Asylum Seekers: A Systematic Review and Meta-Analysis.

Both refugees and asylum seekers exhibit poorer mental health and higher rates of mental disorders, particularly posttraumatic stress disorder (PTSD), for which EMDR therapy has been shown to be effective. This review analyses the efficacy of EMDR in reducing PTDS in refugees or asylum seekers using randomized controlled studies (RCTs). A systematic review and meta-analysis published in PROSPERO (CRD42024595506) using the databases PubMed, PsycINFO and Web of Science were conducted.