Colorectal cancer lymph node dissection and disease survival.

The debate regarding the two possible roles of lymphadenectomy in surgical oncology, prognostic or therapeutic, is still ongoing. Furthermore, the use of lymphadenectomy as a proxy for the quality of the surgical procedure is another feature of discussion. Nevertheless, this reckoning depends on patient conditions, aggressiveness of the tumor, the surgeon, and the pathologist, and then it is not an absolute surrogate for the surgical quality.

Mapping two decades of research in rheumatology-specific journals: a topic modeling analysis with BERTopic.

Background: Rheumatology has experienced notable changes in the last decades. New drugs, including biologic agents and Janus kinase (JAK) inhibitors, have blossomed. Concepts such as window of opportunity, arthralgia suspicious for progression, or difficult-to-treat rheumatoid arthritis (RA) have appeared; and new management approaches and strategies such as treat-to-target have become popular.

Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.

Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.

Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.

Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories.

Background: Visceral leishmaniosis (VL) is the most severe form of human leishmaniosis, with an estimated 95% case fatality if left untreated. Dogs act as peridomestic reservoir hosts for the protozoan parasite Leishmania infantum, a causative agent for human leishmaniosis, endemic throughout the Mediterranean basin. To assure consistent and accurate surveillance of canine infection and prevent transmission to people, consistent diagnosis of canine L.

Reproducibility and reliability of dental arch measurements: comparing of manual, digital, and app-based methods.

Background: Knowing the available dental space in a patient is crucial for orthodontists to develop a good treatment plan.

Objectives: To compare and evaluate the reliability, reproducibility, and accuracy of three measurement methods on models: conventional, mobile app, and digital software.

Materials And Methods: Maxillary and mandibular dental plaster models of 20 subjects with permanent dentition were analyzed.

Retraction notice to "Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases"[Chemosphere 307 (2022) 136020].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Reformulating real-time random safety analysis during the SARS-CoV-2 pandemic.

Introduction: From a safety perspective, the pandemic imposed atypical work dynamics that led to noticeable gaps in clinical safety across all levels of health care.

Objectives: To verify that Real-Time Random Safety Analyses (AASTRE) are feasible and useful in a high-pressure care setting.

Design: Prospective study (January-September 2022).

[Translated article] Drug dosing in obese critically ill patients, a literature review.

Introduction: Obesity constitutes a global public health problem, and knowledge about drug dosing in obese patients is limited. Clinical trials in critically ill patients rarely include obese individuals, resulting in a lack of specific dosing information in product data sheets. The aim of this literature review is to provide clinicians with efficient and safe guidelines for this group of patients.

Long-Term Survival Analysis of Low Back Pain Onset in Patients Undergoing Hip Prosthesis Surgery: A Kaplan-Meier Study.

Introduction: Total hip arthroplasty has been associated with the onset of low back pain, which can significantly impact patients' quality of life. However, a detailed evaluation of the time until the onset of long-term low back pain following total hip arthroplasty remains largely unknown. This study aimed to explore the relationship between total hip arthroplasty and the development of long-term lower back pain.

Integration of responses to lithium in mussels at different levels of biological complexity.

The increasing use of lithium (Li) in modern technology and medicine has raised up concerns in the scientific community due to the potential impact of this metal on the aquatic environment. Although several effects have been reported in different organisms, there is still scarce information concerning the mechanisms and chronic effects of Li toxicity in marine life. Our main objective is to determine biological effects of sub-lethal concentrations in Mytilus galloprovincialis at different biological organization levels using the biomarker approach.

The efficacy of longer-term lebrikizumab treatment in patients with moderate-to-severe atopic dermatitis who did not meet protocol-defined response criteria at week 16 in two randomized controlled clinical trials.

Background: Lebrikizumab demonstrated statistically significant improvements in patients with moderate-to-severe atopic dermatitis at week 16 with a durable response up to week 52.

Objective: To investigate the efficacy of lebrikizumab-treated patients at 52 weeks who did not achieve the ADvocate1 and ADvocate2 protocol-defined response criteria (≥75% improvement in the Eczema Area and Severity Index [EASI 75] or Investigator Global Assessment [IGA] 0/1 with ≥2-point improvement without rescue medication) after 16 weeks.

Methods: This analysis includes observed data for patients who received lebrikizumab every 2 weeks during the induction period, did not achieve the protocol-defined response, and subsequently received open-label lebrikizumab treatment.

A novel way to use cross-validation to measure connectivity by machine learning allows epilepsy surgery outcome prediction.

The rate of success of epilepsy surgery, ensuring seizure-freedom, is limited by the lack of epileptogenicity biomarkers. Previous evidence supports the critical role of functional connectivity during seizure generation to characterize the epileptogenic network (EN). However, EN dynamics is highly variable across patients, hindering the development of diagnostic biomarkers.

The excess direct social cost of dementia-related neuropsychiatric symptoms: a beyond silos region-wide cohort study.

Objectives: The objective was to estimate the excess formal social costs or direct non-healthcare costs of dementia-related neuropsychiatric symptoms (NPS).

Methods: The presence of dementia, NPS, antipsychotic and/or antidepressant use, somatic and psychiatric comorbidities, and formal social benefits were studied in a region-wide cohort of all over-60-year-olds. A random forest-based algorithm identified NPS and two-part regression models and entropy balance were used.

Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed when the disease is already at an advanced stage. Chemotherapy typically has only a modest effect, making surgery the most effective treatment option. However, only a small percentage of patients are amenable to surgery.

Ultrasound-guided percutaneous release of the ulnar nerve at the elbow.

Introduction: Surgical treatment of ulnar tunnel syndrome is controversial, with no consensus on the ideal procedure. Nevertheless, in-situ decompression seems to provide faster recovery with less morbidity than neurolysis-transposition. The aim of this retrospective study was to validate a new percutaneous technique using ultrasonography.

The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in no trauma/low trauma women.

Women are known to have twice as much lifetime prevalence of post-traumatic stress disorder (PTSD) as men do. It has been reported that the risk genotype (CC) of a single nucleotide polymorphism (SNP) (rs2267735) in the pituitary adenylate cyclase-activating polypeptide (PACAP-PAC1R) system is associated with PTSD risk and altered fear conditioning and fear extinction in women. Surprisingly, no previous work has studied the effect of this SNP on fear conditioning, extinction, or generalization in non-traumatized/low trauma load women.

Tackling ALT-positive neuroblastoma: is it time to redefine risk classification systems? A systematic review with IPD meta-analysis.

Background: The heterogeneous prognosis in neuroblastoma, shaped by telomere maintenance mechanisms (TMMs), notably the alternative lengthening of telomeres (ALT) pathway, necessitates a refined risk classification for high-risk patients. Current systems often lack precision, hindering tailored treatment approaches. This individual participant data (IPD) meta-analysis of survival among ALT-positive patients aims to improve risk classification systems, enhancing therapeutic strategies and patient outcomes.

Assessment of European countries' national circular economy policies.

The circular economy (CE) has become key to achieving the environmental objectives set by the European Union (EU). This transformative process requires linear production processes to be abandoned and replaced with environmentally-friendly circular models. In this scenario, the present study uses Data Envelopment Analysis and the Sequential Malmquist Index to achieve a twofold objective: (1) to analyse the effectiveness of the national CE policies applied by 19 EU Member States and (2) to identify the items of circularity that need improvement, in order to support decision-makers in the implementation of appropriate CE policies.

Energy poverty and health inequalities in Barcelona: A cross-sectional trends study in the context of COVID-19, energy crisis and climate change, 2016-2021.

The aim of this study was to analyse the time trends in Barcelona before and during the adverse context of COVID-19, energy crisis, and climate change in 1) the energy poverty (EP) prevalence; 2) the association between EP and health and 3) the impact of EP on health, according to the axes of inequality (sex, age, social class, and country of birth). We conducted a cross-sectional trends study using data from the 2016 and 2021 Barcelona Health Survey. This study clearly recognizes that EP continues to be an important public health problem in the context of Barcelona.

Effects of stretching exercise on walking performance and balance in older adults: A systematic review and meta-analysis.

This systematic review aimed to analyse the literature on the effects of stretching exercise as a strategy to improve walking performance and balance in older adults. A literature search was performed in five databases up to October 2023 for randomized clinical trials addressing the effects of stretching exercise programs in older adults. The methodological quality was evaluated through the PEDro scale.

Acute suppurative thyroiditis in a child secondary to pyriform sinus fistula: From single case to systematic review.

Acute suppurative thyroiditis (AST), a rare yet potentially life-threatening infection, comprises less than 1 % of neck pathologies and requires prompt treatment. Symptoms range from neck pain and fever to dysphagia and possible abscess formation. Broad-spectrum antibiotics are the primary treatment; however, surgical drainage may be necessary for abscesses to prevent systemic infection.