Overlap autoimmune hepatitis and primary sclerosing cholangitis in a patient with multiple sclerosis.

A 16-year-old boy was diagnosed from multiple sclerosis (MS) after suffering from paresthesia in upper limbs and VI cranial nerve paresis. Corticosteroids and fingolimod were started. After 13 months a worsening of liver biochemical tests (LBT) was noticed: ALP 787 U/L, GGT 737 U/L, AST 195, ALT 321, Bi 0.

Assessment of potentially unnecessary antibiotic use for suspected urinary tract infections in nursing homes using a simplified algorithm.

Background: Nursing home (NH) residents are frequently treated with antibiotics for urinary tract infections (UTIs), often due to overdiagnosis. The aim of this study was to evaluate the proportion of potentially unnecessary antibiotic use for suspected UTIs in NHs across eight European countries.

Research Design And Methods: Over a three-month period (February to April 2024), NH professionals recorded information on all antibiotic treatments for UTIs using a specific registration chart.

Conceptual and Evidence Update on Incidental Physical Activity: A Scoping Review of Experimental and Observational Studies.

Promoting incidental physical activity (IPA) can help reduce sedentary lifestyles and physical inactivity levels in the population. However, there is heterogeneity in the definition of IPA, and studies have yet to synthesize the empirical findings on this topic. This review aimed to (1) Synthesize the definitions of the IPA used in the scientific literature, (2) Identify the behaviors part of the IPA, and (3) Synthesize the main findings on IPA.

Ground and excited state aromaticity in azulene-based helicenes.

Electron delocalization is studied in the ground singlet and first excited triplet states of azulene-containing helicenes. After showing that the compounds we study can be synthesized, we show that they exhibit a charge separation in the ground state, which does not appear in their triplet excited state. Then, magnetically induced properties (IMS3D and ACID) and electron density decomposition methods (EDDB) are used to rationalize aromaticity in these systems.

Effect of Nitrogen and Phosphorus Doping of Reduced Graphene Oxide in the Hydrogen Evolution Catalytic Activity of Supported Ru Nanoparticles.

Three different cathodic materials for the hydrogen evolution reaction (HER) consisting of Ru nanoparticles (NPs) supported onto a bare and two doped reduced graphene oxides (r-GO) have been studied. Ru NPs have been synthesized in situ by means of the organometallic approach in the presence of each reduced graphene support (bare (rGO), N-doped (NH-rGO) and P-doped (P-rGO)). (HR)TEM, EDX, EA, ICP-OES, XPS, Raman and NMR techniques have been used to fully characterize the obtained rGO-supported Ru materials.

Human Cytomegalovirus Infection Induces Long-Term Changes in the Cytokine Milieu of Kidney Transplant Recipients.

The impact of human cytomegalovirus (HCMV) infection on the mid- and long-term balance between pro-inflammatory and anti-inflammatory cytokines among kidney transplant recipients (KTRs) remains unclear. We measured plasma levels of 12 Th1/Th2-type cytokines (granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin [IL]-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, IL-18 and tumor necrosis factor-α) in a cohort of 290 KTRs at four time points through month 12 after transplantation. Cytokine levels at each point were compared according to the previous documentation of HCMV replication by two approaches: "cumulative exposure" from the time of transplantation and "recent exposure" within the 2-3 months preceding cytokine assessment.

Exploration of low-sulfonate lignin electrospinning conditions for the development of new renewable lubricant formulations.

This study explores the preparation of lubricating oleo-dispersions using electrospun nanofibrous mats made from low-sulfonate lignin (LSL) and polycaprolactone (PCL). The rheological and tribological properties of the oleo-dispersions were significantly modulated for the first time through the exploration of LSL/PCL ratio and electrospinning conditions such as applied voltage, distance between the tip and collector, flow rate, ambient humidity, and collector configuration. Adequate uniform ultrathin fibers and Small-amplitude oscillatory shear (SAOS) functions of the oleo-dispersions, with storage modulus values ranging from 10 to 10 Pa at 25 °C, were obtained with a flow rate of 0.

Is lipedema a progressive disease?

Background: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.

Methods: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up.

Analysis of Social Genetic Effects on Pigs Fed With Automatic Feeders Using a Visit-Based Approach.

Social behaviour traits and their impact on feed efficiency are of particular interest in pig farming. The integration of automatic feeders enables the collection of multiple phenotypes for breeding purposes. The additive genetic and social genetic effect can be estimated considering all the visits to the feeder by modelling each visit independently in a 'visit-based approach'.

Endoscopic thoracic sympathectomy for primary hyperhidrosis: an over a decade-long follow-up on efficacy, impact, and patient satisfaction.

Background: Endoscopic thoracic sympathectomy is a well-known and effective treatment for palmar and axillary primary hyperhidrosis (PHH). Its most frequent drawback and the main complaint among patients who underwent surgery is the appearance of compensatory sweating (CS). To date, no long-term studies using internationally standardized tools have assessed the efficacy and impact of this surgery on patients.

Prognostic roles of hematological indicators in programmed cell death protein 1/programmed cell death ligand 1 inhibitors for small-cell lung cancer: a retrospective cohort study.

Background: Lung cancer is the main cause of cancer death in the world, with small-cell lung cancer (SCLC) accounting for about 10-15% of all lung cancers. Although programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors represent a major breakthrough in SCLC treatment, only a minority of patients will benefit and there is still a lack of accurate biomarkers to guide clinical application. Inflammation plays a crucial role in tumorigenesis, tumor development, metastasis, and drug resistance, but there is limited research on the predictive value of these inflammatory indicators in SCLC.

Non-infectious pulmonary complications after haematopoietic progenitor transplantation: a diagnostic approach.

Haematopoietic stem cell transplantation (HCT) is an established treatment for a wide variety of haematological diseases, both malignant and non-malignant. Infectious and non-infectious post-HCT pulmonary complications are a major cause of morbidity and mortality, with non-infectious complications becoming more prominent in recent decades as prophylaxis has led to a decrease in infectious complications. Globally, these complications can be divided into three phases (neutropenic, early and late phase) depending on their time of onset in relation to the graft.

Single minimal conjunctival incision for rectus muscles: a pilot feasibility study.

Background: Small conjunctival incision size is desirable in strabismus surgery under topical anesthesia.

Objective: To study the feasibility and tolerability of a small bulbar conjunctival incision (SB).

Design: Non-randomized feasibility pilot study.

Examining the prevention approach in National Dementia Plans from European and North American countries.

Objectives: This paper aims to provide a comprehensive review of National Dementia Plans (NDPs) from selected European and North American countries, focusing on the distinct prevention strategies outlined and the approaches employed for reducing dementia risk.

Method: The sample consisted of 16 NDPs from Austria, Canada, Finland, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Malta, the Netherlands, Spain, Switzerland, the UK, and the USA. These NDPs were retrieved from the Alzheimer's Disease International (ADI) database, with regular updates checked on official governmental websites.

Demography and homing behavior in the poorly-known Philippine flat-headed frog (Anura: Bombinatoridae).

The flat-headed frog, , is a poorly known, riverine species, endemic to the province of Palawan in the Philippines. We applied capture-mark-recapture (CMR) methods to follow individuals at two sites (Malbato and San Rafael) in the island of Busuanga over 10 months in 2022-2023. We used passive internal transponders (PITs) to mark adult and subadults and single-colored visual internal elastomers (VIEs) for cohorts of juveniles.

adapted to steppe-desert climate extremes one million years ago.

Questions about when early members of the genus adapted to extreme environments like deserts and rainforests have traditionally focused on . Here, we present multidisciplinary evidence from Engaji Nanyori in Tanzania's Oldupai Gorge, revealing that thrived in hyperarid landscapes one million years ago. Using biogeochemical analyses, precise chronometric dating, palaeoclimate simulations, biome modeling, fire history reconstructions, palaeobotanical studies, faunal assemblages, and archeological evidence, we reconstruct an environment dominated by semidesert shrubland.

Evaluation of three fixation methods in tibiotalocalcaneal fusion for chronic osteomyelitis following ankle fracture.

Introduction: In the scenario of chronic osteomyelitis following an ankle fracture, limb salvage and ideally infection eradication, can be an alternative to amputation.Tibiotalocalcaneal arthrodesis is perhaps the most popular procedure. When performing fusion in osteomyelitis patients, external fixation is more commonly used, although there is some experience with internal fixation.

Large-scale commercial-grade volatile fatty acids production from sewage sludge and food waste: A holistic environmental assessment.

The valorization of sewage sludge and food waste to produce energy and fertilizers is a well-stablished strategy within the circular economy. Despite the success of numerous laboratory-scale experiments in converting waste into high-value products such as volatile fatty acids (VFAs), large-scale implementation remains limited due to various technical and environmental challenges. Here, we evaluate the environmental performance of a hypothetical large-scale VFAs biorefinery located in Galicia, Spain, which integrates fermentation and purification processes to obtain commercial-grade VFAs based on primary data from pilot plant operations.

A non-interventional biomarker study in patients with adenocarcinoma of the lung treated with nintedanib plus docetaxel following progression on chemotherapy and/or immunotherapy: LUME-BioNIS.

Background: Anti-angiogenic agents, such as nintedanib and ramucirumab, when combined with docetaxel, are subsequent treatment options in patients with non-small cell lung cancer (NSCLC) who have failed on first-line chemotherapy or immunochemotherapy. However, to date, there are no validated predictive biomarkers for efficacy of anti-angiogenic therapies in this setting. The aim of this study was to explore whether genetic or genomic markers, alone or combined with clinical covariates, could be used to predict overall survival (OS) in patients with NSCLC who are eligible for treatment with nintedanib plus docetaxel.

Short- and long-term outcomes of percutaneous left atrial appendage occlusion in cancer patients.

Introduction And Objectives: Percutaneous left atrial appendage occlusion (LAAO) is a viable option to mitigate bleeding and stroke risks in patients with atrial fibrillation (AF) who are not eligible for oral anticoagulation. Its safety and efficacy in cancer patients remain unclear due to their exclusion from trials. This study aimed to compare short- and long-term LAAO outcomes between cancer and non-cancer patients.

Climate signal age effects in tree-ring density data from the Spanish Pyrenees.

Key Message:

Abstract: Tree-rings are the prime archive for high-resolution climate information over the past two millennia. However, the accuracy of annually resolved reconstructions from tree-rings can be constrained by what is known as climate signal age effects (CSAE), encompassing changes in the sensitivity of tree growth to climate over their lifespans. Here, we evaluate CSAE in from an upper tree line site in the Spanish central Pyrenees, Lake Gerber, which became a key location for reconstructing western Mediterranean summer temperatures at annual resolution.

Climate change aggravated wildfire behaviour in the Iberian Peninsula in recent years.

Climate change is considered to affect wildfire spread both by increasing fuel dryness and by altering vegetation mass and structure. However, the direct effect of global warming on wildfires is hard to quantify due to the multiple non-climatic factors involved in their ignition and spread. By combining wildfire observations with the latest generation of climate models, here we show that more than half of the large wildfires (area>500 ha) occurring in the Iberian Peninsula between 2001 and 2021 present a significant increase in the rate of spread with respect to what it would have been in the pre-industrial period, attributable to global warming.