Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted 'SWATH' Mass Spectrometry.

Aim: To discover new salivary biomarkers to diagnose periodontitis and evaluate the impact of age and smoking on predictive capacity.

Material And Methods: Saliva samples were collected from 44 healthy periodontal individuals and 41 with periodontitis. Samples were analysed by sequential window acquisition of all theoretical mass spectra (SWATH-MS), and proteins were identified by employing the UniProt database.

Faecal calprotectin-based strategy for long-term monitoring of patients with Crohn's disease without or with mild endoscopic postoperative recurrence.

Background: Endoscopic evaluation 6-12 months after ileocolonic resection (ICR) in Crohn's disease (CD) is advised to assess the development of postoperative recurrence (POR) but no further recommendations are available for long-term monitoring if no POR is noticed.

Methods: Prospective, open-label, study including asymptomatic patients with CD and ICR in whom no POR was observed at the last endoscopic evaluation. Patients were followed-up for two years and ileocolonoscopy was performed by means of a faecal calprotectin (FC)-based strategy.

Hepato-thoracic cystic echinococcosis transit. Clinical features, postoperative complications and hospital mortality. A systematic review.

Background: Hepato-thoracic hydatid transit (HTT) is an evolutionary complication of hepatic cystic echinococcosis. This study aimed to report the available evidence regarding postoperative complications (POC) and hospital mortality (HM).

Methods: Systematic review.

Alternative splicing controls pan-neuronal homeobox gene expression.

The pan-neuronally expressed and phylogenetically conserved CUT homeobox gene orchestrates pan-neuronal gene expression throughout the nervous system of As in many other species, including humans, is encoded by a complex locus that also codes for a Golgi-localized protein, called CASP (Cux1 alternatively spliced product) in humans and CONE-1 ("CASP of nematodes") in How gene expression from this complex locus is controlled-and, in , directed to all cells of the nervous system-has not been investigated. We show here that pan-neuronal expression of CEH-44/CUX is controlled by a pan-neuronal RNA splicing factor, UNC-75, the homolog of vertebrate CELF proteins. During embryogenesis, the locus exclusively produces the Golgi-localized CONE-1/CASP protein in all tissues, but upon the onset of postmitotic terminal differentiation of neurons, UNC-75/CELF induces the production of the alternative CEH-44/CUX CUT homeobox gene-encoding transcript exclusively in the nervous system.

Proportional Condylectomy for the Treatment of Unilateral Condylar Hyperplasia With Maloclussion: Role of Point-of-Care Manufacturing Surgical Guides and Intraoperative Computed Tomography to Avoid Secondary Orthognatic Surgery.

Condylar hyperplasia (CH) is a complex, usually unilateral pathology affecting the jaw, leading to facial asymmetry and malocclusion. Its etiology is unclear, with potential links to endocrine disorders, trauma, and genetic factors. Unilateral condylar hyperplasia (UCH) typically presents in young patients but can occur at any age.

Organoids, tissue slices and organotypic cultures: advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models.

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses of all common solid cancers. For the large majority of PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought the advances seen in other cancer types.

Development of a New Score Based on Image Defined Risk Factors to Standardize Surgical Risk in Neuroblastoma Resection - A SIOPEN Collaborative Study.

Background And Aims: Image Defined Risk Factors (IDRFs) assess surgical risk in neuroblastoma (NB) and guide neoadjuvant therapy. Despite chemotherapy IDRFs may persist in 70 % of cases. Several studies have suggested that not all IDRFs hold equal significance and that the presence of an IDRF does not inherently signify unresectability.

Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2-5 years old in 3 Canadian birth cohorts.

Background: More than 80% of the Canadian population lives in urban settings. Urban areas usually bring exposure to poorer air quality, less access to green spaces, and higher building density. These environmental factors may endanger child development.

Understanding sediment wash-off in road drainage systems under intense rainfall and high sediment masses: Insights from a large-scale modeling facility.

The main objective of this paper is to analyze, through a unique large-scale modeling facility, the RDS wash-off under various scenarios of intense rainfall and high RDS masses. A 1:1 scale physical modeling facility was used to allow precise measurement of the RDS wash-off phenomenon under two different rainfall intensities (30/50 mm/h) and three initial RDS masses (100/150/200 g/m). The accumulated and discharged masses of RDS in the different components of the modeling facility (roadway/RW, gully pot/GP and manhole/MH) were collected at the end of the wash-off simulations.

Platelet-rich plasma enhances remodeling of combined gastrocnemius muscle and achilles tendon injuries in rat model: Reducing fibrosis, modulating gene (MMP9, Bax, HMGB1, and IGF) expression, and restoring histopathological and ultrastructural changes.

Muscle and tendon injuries are prevalent occurrences during sports activities. Platelet-rich plasma (PRP) is known for its rich content of factors essential for wound healing, inflammation reduction, and tissue repair. Despite its recognized benefits, limited information is available regarding PRP's effectiveness in addressing combined surgical injuries to the gastrocnemius muscle and Achilles tendon.

Characterization, prognostic factors, and clinical profile of ear infections by Turicella otitidis: Revealing the emerging rise of a controversial pathogen.

Introduction: Environmental changes and modifications in leisure habits have facilitated the emergence of new bacteria responsible for causing ear infections with different presentations. In this context, Turicella otitidis is a pathogen for which isolated cases of external and middle ear infections have been reported. However, our experience indicates a resurgence in its occurrence in recent years.

Evaluating prognostic factors for falls in Parkinson's disease: A sex-based analysis.

Introduction: Falls are a common and debilitating complication in Parkinson's disease (PD). Previous studies have primarily focused on cohorts with prevalent falls or advanced disease stages. This study assessed risk factors for falls in early-stage falls-naïve cohort stratified by sex.

Genetic selection for postweaning growth rate shows no relevant negative impact on reproductive performance in breeding rabbit does.

Genetic selection for growth rate has often been related with potential negative effects on various reproductive traits across different species. Using rabbit as a model, this study has evaluated for the first time how genetic selection for growth rate has affected feed efficiency, resource allocation, blood traits, reproductive performance and survival during five reproductive cycles in rabbit does. To this end, we used 88 reproductive rabbit females from two vitrified and rederived populations of the same paternal line, differing only in 18 generations of genetic selection for growth rate (n = 44 for R19V and n = 44 for RV37V).

Electro-bioremediation of wastewater: Transitioning the focus on pure cultures to elucidate the missing mechanistic insights upon electro-assisted biodegradation of exemplary pollutants.

Electro-bioremediation of exemplary water pollutants such as nitrogenous, phosphorous, and sulphurous compounds, hydrocarbons, metals and azo dyes has already been studied at a macro-scale level using mixed cultures. The technology has been generally established as a proof of concept at the technology readiness level (TRL) of 3, and there are already specific cases where the technology reached TRL 5. However, this technology is less utilized compared to traditional approaches.

Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches.

The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers.

Value of ultrasound-assessed dactylitis in the early diagnosis of psoriatic arthritis.

Purpose: The primary objective of this prospective, longitudinal, observational, single-centre study was to evaluate the association between ultrasound-assessed lesions of dactylitis and the diagnosis of psoriatic arthritis (PsA) in patients with psoriasis (PsO) and hand arthralgia.

Methods: We included adult patients diagnosed with PsO with hand arthralgia, with or without other musculoskeletal complaints. They were clinically assessed at baseline, 6 and 12 months by a rheumatologist blinded to the ultrasound findings.

Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co-pathology.

Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta-amyloid peptide (Aβ), has a prion-like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3-4 decades.

Understanding the pathways to text generation: A longitudinal study on executive functions, oral language, and transcription skills from kindergarten to first grade.

This longitudinal study explored the contribution of transcription skills, oral language abilities, and executive functions in kindergarten to written production in grade 1 among Spanish-speaking children (N = 191) through structural equation modeling (SEM). Three dimentions of written production were assessed, including productivity, quality, and syntactic complexity. Accordingly, three SEM models were tested to explore these relationships, and the estimated models for each endogenous variable demonstrated good fit.

Qualitative evaluation of survey questions to assess treatment preference for daily oral or long‑acting injectable antiretroviral therapy among people living with HIV.

Treatment of HIV has historically required taking daily oral antiretroviral therapy (ART). A recent alternative to daily oral ART is long-acting injectable ART with cabotegravir plus rilpivirine, administered monthly or every 2 months. The purpose of this qualitative study was to evaluate the concept relevance and interpretability of five previously developed questions: one treatment preference question and four questions designed to assess how the emotional burden associated with HIV treatment impacts treatment preferences.

Values associated with Nordic Walking: An international cross-sectional survey among individuals practicing walking with poles.

Introduction: The article is devoted to the sociological exploration of the social phenomenon that Nordic Walking has become in Europe and worldwide over the recent decades.

Aim: It is based on the results of original international sociological research study on the issue of sociodemographic profiles of Nordic Walkers in the context of the values associated with this sports activity.

Methods: A cross-sectional quantitative study with convenience sampling study was performed among 416 Poles, 132 Europeans from 11 countries (Germany, the UK, Spain, France, Italy, Portugal, Ireland, Denmark, Austria, Sweden, and Norway), and 212 participants from 5 non-European countries (the USA, Canada, Australia, New Zealand, and Japan).

Gendered dimension of chronic pain patients with low and middle income: A text mining analysis.

Methods: This is a mixed-method study using individual interviews (duration between 40-60 minutes) of 181 CNCP patients (71% females) in a tertiary Pain Care Unit, and applying the text mining methodology. Incomes (low or middle) and gender roles (productive vs. reproductive)".

Photoinduced Reductive C-O Couplings from Unsymmetrical Bis-Cyclometalated Pt(IV) Dicarboxylato Complexes.

Unsymmetrical bis-cyclometalated dicarboxylato complexes (-6-32)-[Pt(tpy)(OCR)] [tpy = cyclometalated 2-(-tolyl)pyridine, R = -Bu (), Me (), Ph (), CF ()], are obtained from the reaction of -[Pt(tpy)] with the appropriate PhI(OCR) reagent. Treatment of complexes of this type with different carboxylates (R'CO) results in the formation of mixed-carboxylato derivatives, namely (-6-43)-[Pt(tpy)(OCMe)(OCR')] [R' = -Bu (), CF (), Ph ()], (-6-34)-[Pt(tpy)(OCCF)(OCR')] [R' = -Bu (), Me (), Ph ()], and (-6-34)-[Pt(tpy)(OC--Bu)(OCMe)] (). Irradiation of - and - with UV light (365 nm) in MeCN gives 5-methyl-2-(2-pyridyl)phenyl pivalate (), 5-methyl-2-(2-pyridyl)phenyl acetate () or 5-methyl-2-(2-pyridyl)phenyl benzoate () as the major photoproduct from most complexes, resulting from a reductive C-O coupling between a tpy ligand and a carboxylato ligand.