Epsilon Toxin from Induces the Generation of Extracellular Vesicles in HeLa Cells Overexpressing Myelin and Lymphocyte Protein.

Epsilon toxin (ETX) from is a pore-forming toxin (PFT) that crosses the blood-brain barrier and binds to myelin structures. In in vitro assays, ETX causes oligodendrocyte impairment, subsequently leading to demyelination. In fact, ETX has been associated with triggering multiple sclerosis.

Age Is Just a Number: Ontogenetic Conservation in Activation of Blood Clotting Factors VII, X, and XII by Caucasus Blunt-Nosed Viper () Venoms.

This study examined the pathophysiological effects of venoms from neonate and adult specimens of the viperid snake , focusing on their ability to activate various blood clotting factors in human plasma. All venoms exhibited strong procoagulant properties. In concentration-response tests, the clotting potency of the neonate venoms fell within the range of their parents' maximum clotting velocities and areas under the curve.

Bibliometric Analysis of Anxiety and Physical Education in Web of Science-A Performance and Co-Word Study.

This study conducts a comprehensive bibliometric analysis of the concepts 'physical edu- cation' and 'anxiety' (PHYEDU_ANX) in the Web of Science (WoS) database. No previous biblio- metric studies were found that addressed this intersection, so this research is a pioneering exploration of this knowledge gap. The aim of the study is to examine the presence of both concepts in the scientific literature, identifying their trends, approaches, and future prospects.

The Operational Performance of an Ultrafiltration Pilot Unit for the Treatment of Ultra-Concentrated Brines.

The valorization of ultra-concentrated seawater brines, named bitterns, requires preliminary purification processes, such as membrane filtration, before they can be fully exploited. This study investigates the performance of an ultrafiltration pilot plant aimed at separating organic matter and large particles from real bitterns. An empirical model for the bittern viscosity was developed to better characterize the membrane.

Polysulfone-Based Membranes Modified with Ionic Liquids and Silica for Potential Fuel Cell Applications.

The urgent need for sustainable, low-emission energy solutions has positioned proton exchange membrane fuel cells (PEMFCs) as a promising technology in clean energy conversion. Polysulfone (PSF) membranes with incorporated ionic liquid (IL) and hydrophobic polydimethylsiloxane-functionalized silica (SiO-PDMS) were developed and characterized for their potential application in PEMFCs. Using a phase inversion method, membranes with various combinations of PSFs, SiO-PDMS, and 1-butyl-3-methylimidazolium triflate (BMI.

Reverse Osmosis Membrane Engineering: Multidirectional Analysis Using Bibliometric, Machine Learning, Data, and Text Mining Approaches.

Membrane engineering is a complex field involving the development of the most suitable membrane process for specific purposes and dealing with the design and operation of membrane technologies. This study analyzed 1424 articles on reverse osmosis (RO) membrane engineering from the Scopus database to provide guidance for future studies. The results show that since the first article was published in 1964, the domain has gained popularity, especially since 2009.

Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study.

Cauda equina nerve roots may become damaged during neuraxial anesthesia, and post-puncture headache may appear in the case of cerebrospinal fluid leakage if needle tips are deformed due to bone contact when several attempts are needed. Our aim was to verify the correlation between skin-transverse process distance (st) and skin-dural sac distance (d) for calculation of optimal angles in a free visual guide and as a reference for the maximal depth to be traversed by the needle. Randomly selected ex vivo samples ( = 10) were flexed to reproduce the position of the lumbosacral spine during spinal anesthesia.

Understanding Family Experiences: A Study on Mental Health Literacy in Adolescent Eating Disorder Diagnoses.

Background: Adolescent eating disorders pose a significant public health challenge and strongly affect both physical and emotional well-being. Early diagnosis is important for improving treatment outcomes, though it remains complex due to multiple influencing factors. The family perspective is essential in this process, as it provides valuable insights into changes in adolescents' habits and emotional health.

Use of Hormone Blockers in Transgender Teenagers: A Scoping Review.

Hormone blockers are defined as substances that suppress the release of sex hormones, thus inhibiting the development of secondary sexual characteristics in teenagers. There is currently an increase in young people seeking healthcare services due to a mismatch between their birth-assigned gender and their perceived or self-identified gender. In early childhood, individuals are not usually affected by their physical appearance.

Ageism and Associated Factors in Healthcare Workers: A Systematic Review.

: Ageism refers to the presence of stereotypes, prejudices, and discrimination against older adults based on their age. In healthcare settings it negatively impacts opportunities for treatment, rehabilitation, and cure opportunities. This study aims to assess the presence of ageism among healthcare workers toward older patients and to identify the associated sociodemographic, personal, and work-related factors.

Impact of Work-Family Balance on Nurses' Perceived Quality of Life During the COVID-19 Pandemic: A Scoping Review.

Background/objectives: The COVID-19 pandemic has put nurses under extreme pressure, especially affecting them by significantly increasing their workload and compromising their well-being. The lack of balance between work and personal life has caused greater stress and burnout in these professionals, deteriorating their quality of life and the care they provide. This study aims to synthesize the scientific evidence on the relationship between work-family balance and the perceived quality of life of nurses during the COVID-19 pandemic.

Nursing Students' Experiences About Clinical Practice Tutoring: A Cross-Sectional Observational Study.

Unlabelled: Nursing students' experiences about clinical practice tutoring in a public university from southern Spain and at its two attached educational centres were analysed.

Methods: A cross-sectional observational study was carried out. The population was comprised of nursing students attending their fourth year of university during the 2023/2024 academic period, with a final sample of 179 subjects.

Individualized Care in Nursing Homes Before and After the COVID-19 Pandemic.

: Individualizing care is the essence of nursing, and its benefits have been extensively proven in older people. The changes arisen during the COVID-19 pandemic may have affected it. The aim of this study is to analyze the changes produced in the perceptions about the individualization of care, quality of life, and care environment of elderly people living in long-term care centers before and after the pandemic.

The Long-Lasting Effect of Multidisciplinary Interventions for Emotional and Social Loneliness in Older Community-Dwelling Individuals: A Systematic Review.

Background: Loneliness can occur at any age, but it is more prevalent among older adults due to the associated risk factors. Various interventions exist to improve this situation, but little is known about their long-term effects. Our aims were to determine if these interventions have long-lasting effects and for how long they can be sustained.

Increasing Self-Efficacy for the Management of Patients with Type 2 Diabetes Through an Advanced Practice Education Program for Primary Care Professionals.

Background/objectives: Previous studies have shown that primary care (PC) professionals have a low knowledge about the management of patients with type 2 diabetes, despite being one of the most common chronic diseases. The objective of this study is to analyze the impact of an educational program for health professionals on the metabolic control of their patients diagnosed with type 2 diabetes.

Methods: This work follows a quasi-experimental longitudinal design following a double perspective.

Enhancing Nursing Competencies: An Assessment of Knowledge and Attitudes Toward Dental Trauma Management Among Nursing Students-An Interventional Study.

Introduction: Traumatic dental injuries (TDIs) present a significant challenge for healthcare professionals. Nurses, often the first point of contact for patients, may lack essential knowledge in dental trauma first aid, as noted in the existing literature.

Objective: To assess the knowledge of traumatic dental injuries (TDIs) among undergraduate nursing students before and after a targeted educational intervention.

Social and Mental Health Factors Involved in the Severity of Loneliness in Older Individuals in a Spanish Rural Area.

: Loneliness in older people, especially those living in rural areas, is a phenomenon that has received little attention in research and can have detrimental effects on quality of life. The aim of this study was to evaluate loneliness and the psychosocial factors associated with loneliness in rural Spain, which have been minimally studied. : A cross-sectional study was carried out in a sample of permanently resident older people in the region (Valencia, Spain), a geographic area with very low population density.

Perception of Pediatric Nurses on the Use of Standardized Nursing Handover Process in Intra-Hospital Patients Transfer: Attitudes, Barriers, and Practical Challenges.

Unlabelled: Standardized transfer is an evidence-based framework designed to improve communication between healthcare professionals, reducing risks and ensuring safe, high-quality care. Despite its benefits, implementing this framework in clinical practice poses challenges. Nurses often do not use a systematic guide as a theoretical framework for handovers in daily practice.

Analysis of Nursing Education Curricula in Spain: Integration of Genetic and Genomic Concepts.

The integration of genetics and genomics into nursing practice is essential for addressing genetic pathologies and providing personalized patient care. This study aims to analyze the nursing education curricula across Spanish universities to understand how genetic and genomic concepts are incorporated. Using the "Qué estudiar y dónde en la Universidad" (QEDU) database, an official source provided by the Spanish Ministry of Universities, a systematic review of 4720 teaching guides from 118 university centers was conducted.

Breast Ironing from the Perspective of Transcultural Nursing by Madeleine Leininger: A Narrative Review.

(1) Background: This article addresses the harmful traditional practice of breast ironing, which primarily affects girls and adolescents in several countries, particularly in Cameroon. The practice involves applying heat and pressure to developing breasts to delay their growth, with the goal of protecting girls from sexual abuse, early pregnancy, and forced marriages. While culturally accepted, breast ironing has severe physical, psychological, and social consequences, including damage to mammary glands, pain, infections, and potential long-term health complications.

Effectiveness of Compassion Training on Stress and Anxiety: A Pre-Experimental Study on Nursing Students.

Background: Stress and anxiety are common problems among nursing students, affecting their mental health and academic performance. Compassion training has been shown to be effective in reducing these states.

Objectives: This study evaluated the effects of a compassion-based course on perceived stress and anxiety (state and trait) among nursing students at a state university in Chile.

Learners to Leaders: Impact of Instructor Roles on Nursing Students' Professional Development in Clinical Simulations.

Background/objectives: Clinical simulation is a pivotal educational strategy in nursing, facilitating the integration of theoretical knowledge with practical skills in a safe environment. While the benefits of simulation in enhancing technical and non-technical competencies are well-documented, the transition of nursing students to the role of instructors within these simulations remains underexplored, particularly in the Spanish context. This study aims to investigate how assuming the instructor role in clinical simulations impacts the professional development of fourth-year nursing students.

Energy-Resolved Mass Spectrometry and Mid-Infrared Spectroscopy for Purity Assessment of a Synthetic Peptide Cyclised by Intramolecular Huisgen Click Chemistry.

Cyclic peptides have higher stability and better properties as therapeutic agents than their linear peptide analogues. Consequently, intramolecular click chemistry is becoming an increasingly popular method for the synthesis of cyclic peptides from their isomeric linear peptides. However, assessing the purity of these cyclic peptides by mass spectrometry is a significant challenge, as the linear and cyclic peptides have identical masses.

Selective O/N Separation Using Grazyne Membranes: A Computational Approach Combining Density Functional Theory and Molecular Dynamics.

The separation of oxygen (O) and nitrogen (N) from air is a process of utmost importance nowadays, as both species are vital for numerous fundamental processes essential for our development. Membranes designed for their selective molecule separation have become the materials of choice for researchers, primarily due to their ease of use. The present study proposes grazynes, 2D carbon-based materials consisting of and C atoms, as suitable membranes for separating O and N from air.

Designing and Optimizing Electrode Materials for Energy Harvesting in CAPMIX Cells.

The growing demand for clean, decentralized energy has increased interest in blue energy, which generates power from water with different salt concentrations. Despite its potential as a renewable, low-cost energy source, optimizing electrode materials remains a challenge. This work presents a nanomaterial developed via microwave-assisted sol-gel methodology for blue energy applications, where ion diffusion and charge storage are critical.