First report of in a wolf in Italy: An increasing health concern?

is a zoonotic nematode parasite of worldwide distribution. It is present in Europe with important foci, particularly in Eastern countries and Spain. This species is generally associated with a domestic cycle that involves primarily pigs.

The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency.

Introduction: Human Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4) insufficiency caused by heterozygous germline mutations in is a complex immune dysregulation and immunodeficiency syndrome presenting with reduced penetrance and variable disease expressivity, suggesting the presence of disease modifiers that trigger the disease onset and severity. Various genetic and non-genetic potential triggers have been analyzed in CTLA-4 insufficiency cohorts, however, none of them have revealed a clear association to the disease. Multiple HLA haplotypes have been positively or negatively associated with various autoimmune diseases and inborn errors of immunity (IEI) due to the relevance of MHC in the strength of the T cell responses.

Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production.

Introduction: Despite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since the impact of COVID-19 vaccines on the endothelium remains uncertain, our objective was to assess endothelial activation status before and 90 days after the third dose of the BNT162b2 mRNA COVID-19 vaccine.

Methods: A prospective longitudinal study was conducted at University General Hospital of Albacete, involving 38 healthy health-care workers.

Corrigendum: A zebrafish model of Ifih1-driven Aicardi-Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients.

[This corrects the article DOI: 10.3389/fimmu.2023.

Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation.

Background: Immune checkpoint inhibitors have revolutionized cancer therapy, but many patients fail to respond or develop resistance, often due to reduced T cell activity. Costimulation via 4-1BB has emerged as a promising approach to enhance the effector function of antigen-primed T cells. Bispecific T cell-engaging (TCE) antibodies are an effective way to provide tumor-specific T cell receptor-mediated signaling to tumor-infiltrating lymphocytes.

Real world efficacy and safety of the advanced hybrid closed-loop system MiniMed 780G (SmartGuard) in children under 7 years of age.

Objective: To evaluate the safety and efficacy of the Medtronic 780G SmartGuard™ AID system in children under 7 years of age with type 1 diabetes (T1D).

Methods: Retrospective analysis of data from children living with T1D under 7 years of age using the MiniMed 780G™ across three pediatric endocrinology units in the Canary Islands. Metabolic control parameters were analyzed from 14 days of pretreatment to 12 months of follow-up.

Bartonella quintana Endocarditis Complicated by Cerebral Stroke: A Case Report.

is rarely associated with neurological manifestations. This report describes a rare case of endocarditis complicated by a cerebral stroke caused by . We also briefly reviewed the neurological clinical spectrum of disease described in the literature.

Evaluating the role of generative AI and color patterns in the dissemination of war imagery and disinformation on social media.

This study explores the evolving role of social media in the spread of misinformation during the Ukraine-Russia conflict, with a focus on how artificial intelligence (AI) contributes to the creation of deceptive war imagery. Specifically, the research examines the relationship between color patterns (LUTs) in war-related visuals and their perceived authenticity, highlighting the economic, political, and social ramifications of such manipulative practices. AI technologies have significantly advanced the production of highly convincing, yet artificial, war imagery, blurring the line between fact and fiction.

Communicating the interdependence of human, animal, and environmental health on X (formerly Twitter): Insights from the one health approach.

The COVID-19 pandemic has underscored societies' need for education and preparedness in addressing global environmental and health crises. Raising public awareness of the interdependence of human, animal, and environmental health is essential to engaging the public in environmental conservation and disease prevention. The One Health approach offers a holistic and multidisciplinary view for tackling challenges related to environmental and health issues by emphasizing the interplay of these three interconnected health dimensions.

Evaluation of 2,3-butanediol derived from whey fermentation as an effective bio-based monomer for waterborne polyurethane dispersions.

Within the context of the circular economy, the transformation of agri-food waste or by-products into valuable products is essential to promoting a transition towards more sustainable and efficient utilisation of resources. Whey is a very abundant by-product of dairy manufacturing. Apart from partial reutilisation in animal feed or some food supplements, the sustainable management and disposal of whey still represent significant environmental challenges.

Phytochemical investigation and assessment of the anti-inflammatory activity of four taxa growing in Turkey.

Introduction: L. has been known as "hogweed" and used for inflammatory diseases, including fever, enteritis, and bronchitis, for many years worldwide. The genus is also prominently recognized for its high content of coumarins, which are considered a significant group of natural compounds known for their noteworthy anti-inflammatory properties.

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties.

The Selectivity Filter (SF) in tetrameric K channels, has a highly conserved sequence, TVGYG, at the extracellular entry to the channel pore region. There, the backbone carbonyl oxygens from the SF residues, create a stack of K binding sites where dehydrated K binds to induce a conductive conformation of the SF. This increases intersubunit interactions and confers a higher stability to the channel against thermal denaturation.

Children's emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children.

Background: Understanding resilience factors in children is essential for developing early mental health interventions. Middle childhood is an understudied developmental stage, with many quantitative measures lacking validation for this age group and not capturing diverse experiences. This study aimed to use body mapping, an arts-based method, as a novel approach to understand 7-10-year-old children's concepts of resilience (including definitions and factors that contribute to resilience) in East London.

Beyond secondary prevention drugs: Added benefit in survival and events of a healthy lifestyle in patients after an acute coronary syndrome.

Objective: To quantify the added clinical benefit of a healthy lifestyle following an acute coronary syndrome (ACS). Our study seeks to answer the question: Is adherence to medical therapy sufficient or a healthy lifestyle provides additional improvement?.

Methods: This is a prospective observational multi-center study of 685 ACS patients.

What is needed to successfully implement the EU HTA Regulation enabling broad patient access in Europe.

There has been a lot of discussion on the technical aspects of the soon to be implemented European Union's Health Technology Assessment (EU HTA) regulation. However, there has been limited discussion on the implementation aspects and the potential limitations from a policy perspective. In May 2024, a group of HTA experts with previous policy responsibilities met in Rome to propose some policy aspects to be considered.

Agriculture data sharing review.

This study conducts a bibliometric analysis of 252 scientific publications from 2001 to 2023, exploring the evolution and emerging trends in agricultural data spaces. Analyzing articles from the Web of Science and Scopus databases, we address six research questions: the current and interconnected key topics in agricultural data spaces (RQ1), the evolution of research themes over time (RQ2), emerging trends in the field (RQ3), the identification of leading researchers (RQ4), and the primary funding sources for this research area (RQ5), the relationship among research data and small farmers (RQ6). Our findings reveal a shift from traditional to innovative research themes, such as the increasing focus on the Internet of Things (IoT), Blockchain, and Digital Storage.

Real-World Impact of Uncontrolled Symptoms and Suboptimal Treatment Response in Patients With Crohn's Disease in the United States and Europe.

Background: Despite a wide range of available treatments, there is limited evidence as to why significant numbers of Crohn's disease (CD) patients do not achieve disease remission or continue to have residual symptom burden. We aimed to quantify the impact of this suboptimal treatment on patient symptom incidence and severity, quality of life (QoL), and work impairment.

Methods: Data were derived from the Adelphi Real World CD Disease Specific Programme, a cross-sectional survey of CD patients and their treating physicians in France, Germany, Italy, Spain, the United Kingdom, and the United States between January 2020 and March 2021.

The effects of warming on loggerhead turtle nesting counts.

Global trends in marine turtle nesting numbers vary by region, influenced by environmental or anthropogenic factors. Our study investigates the potential role of past temperature fluctuations on these trends, particularly whether warmer beaches are linked to increased nesting due to higher female production (since sea turtles have temperature-dependent sex determination). We selected the loggerhead turtle (Caretta caretta) due to its wide distribution, strong philopatry and vulnerability to environmental changes.

Learning Curve in the Extraction of Impacted Lower Third Molars: A Prospective Cohort Study.

Introduction: Third molar removal is one of the most common surgical procedures in dentistry. Therefore, it is important to evaluate the learning curve of dentists undergoing surgical training. Thus, the aims of this study were to assess the performance of oral surgery residents in third molar extractions based on operative time and the occurrence of incidents/complications, and to determine which variables are associated with surgical difficulty.

The chromosome-level genome of the ctenophore Mnemiopsis leidyi A. Agassiz, 1865 reveals a unique immune gene repertoire.

Ctenophora are basal marine metazoans, the sister group of all other animals. Mnemiopsis leidyi is one of the most successful invasive species worldwide with intense ecological and evolutionary research interest. Here, we generated a chromosome-level genome assembly of M.

Phylogenetic signal in primate tooth enamel proteins and its relevance for paleoproteomics.

Ancient tooth enamel, and to some extent dentin and bone, contain characteristic peptides that persist for long periods of time. In particular, peptides from the enamel proteome (enamelome) have been used to reconstruct the phylogenetic relationships of fossil taxa. However, the enamelome is based on only about 10 genes, whose protein products undergo fragmentation in vivo and post mortem.

Meteorin-like protein plasma levels are associated with worse outcomes in de novo heart failure.

Background And Aims: Meteorin-like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated with heart failure (HF), although with contradictory results. Our aim was to ascertain whether this adipokine could estimate the prognosis of HF in de novo HF (DNHF) patients.