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Spain; Fundacion Publica Galega de Medi... Publications | LitMetric

758,005 results match your criteria: "Spain; Fundacion Publica Galega de Medicina Xenomica-SERGAS-IDIS Hospital Clinico Universitario[Affiliation]"

Respiratory health in serious mental illness.

Eur Neuropsychopharmacol

December 2024

Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Avenida Menéndez Pidal, 14004, Córdoba, Spain; Reina Sofia University Hospital, Avenida Menéndez Pidal 7, 14004, Córdoba, Spain; University of Cordoba, Department of Morphological and Sociosanitary Science, Córdoba, Spain.

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The design of efficient bacterial inactivation treatment in wastewater is challenging due to its numerous parameters and the complex composition of wastewater. Although solar photochemical processes (PCPs) provide energy-saving benefits, a balance must be maintained between bacterial inactivation efficiency and experimental costs. Predictive decision tools for bacterial inactivation under various conditions would significantly contribute to optimizing PCP design resources.

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Synthetic data generation in healthcare: A scoping review of reviews on domains, motivations, and future applications.

Int J Med Inform

December 2024

Life Supporting Technologies Research Group, Universidad Politécnica de Madrid, Avda Complutense 30, 28040 Madrid, Spain.

Background: The development of Artificial Intelligence in the healthcare sector is generating a great impact. However, one of the primary challenges for the implementation of this technology is the access to high-quality data due to issues in data collection and regulatory constraints, for which synthetic data is an emerging alternative. While previous research has reviewed synthetic data generation techniques, there is limited focus on their applications and the motivations driving their synthesis.

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Development of a nano-specific safe-by-design module to identify risk management strategies.

Ann Work Expo Health

December 2024

TNO Research Group Risk Analysis for Prevention, Innovation and Development, Princetonlaan 6, PO Box 80015, Utrecht 3584 CB, The Netherlands.

This article describes the development of a Safe-by-Design (SbD) module and its integration into an easy-to-use tool, named the Nano Exposure Quantifier-Safe-by-Design (NEQ-SbD) tool. The NEQ-SbD tool guides its user to lower the exposure to nanomaterials at the worksite where nanomaterials are manipulated or handled during a wide range of activities. This allows the tool user with an informed decision to assess airborne exposure and to select, compare, and identify appropriate risk management measures (RMM).

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Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

J Nanobiotechnology

December 2024

Cancer Stem Cells and Fibroinflammatory Microenvironment Group, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale CSIC-UAM, 28029, Madrid, Spain.

Background: Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but also metastatic lesions are needed. Tumor-Associated Macrophages (TAMs) have emerged as central players, significantly influencing PDAC progression and metastasis.

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Author Correction: Production and use of antigen tetramers to study antigen-specific B cells.

Nat Protoc

December 2024

Department of Medicine, Schroeder Allergy and Immunology Research Institute, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.

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European clinical practice guideline: managing and treating laryngopharyngeal reflux disease.

Eur Arch Otorhinolaryngol

December 2024

Research Committee of Young-Otolaryngologists of the International Federations of Oto-rhino- laryngological Societies (YO-IFOS), Paris, France.

Objective: To propose a European consensus for managing and treating laryngopharyngeal reflux disease (LPRD) to guide primary care and specialist physicians.

Methods: Twenty-three European experts (otolaryngologists, gastroenterologists, surgeons) participated in a modified Delphi process to revise 38 statements about the definition, clinical management, and treatment of LPRD. Three voting rounds were conducted on a 5-point scale and a consensus was defined a priori as agreement by 80% of the experts.

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3D-Printed Dual-Channel Flow-Through Miniaturized Devices with Dual In-Channel Electrochemical Detection.

Anal Chem

December 2024

Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, E-28802 Madrid, Spain.

Here, we present three-dimensional-printed dual-channel flow-through miniaturized devices (3D) with dual electrochemical detection (ED) integrating two working electrodes each in an in-channel configuration (3D-ED). Prussian Blue (PB) shell-gold nanoparticles ((PB)AuNP) core-based electrochemistry was chosen for selective hydrogen peroxide determination. 3D-ED devices exhibited impress stability, identical intrachannel and interchannel electrochemical performances, and excellent interdevice precision with values under 9%, revealing the reliability of the design and fabrication of the devices.

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Objective: The purpose of this study was to explore experiences of family and professional caregivers of persons with dementia in order to design a tailored community-based support programme.

Design: A two-stage study was deployed. First, qualitative research draws on three focus groups.

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Study Question: Is it possible to predict an euploid chromosomal constitution and identify a transcriptomic profile compatible with extended embryonic development from RNA sequencing (RNA-Seq) data?

Summary Answer: It has been possible to obtain a karyotype comparable to preimplantation genetic testing for aneuploidy (PGT-A), in addition to a transcriptomic signature of embryos which might be suggestive of improved implantation capacity.

What Is Known Already: Conventional assessment of embryo competence, based on morphology and morphokinetic, lacks knowledge of molecular aspects and faces controversy in predicting ploidy status. Understanding the embryonic transcriptome is crucial, as gene expression influences development and implantation.

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This study investigated the speciation and aqueous dissolution of macronutrients in fire ash from diverse ecosystems and speciation of ash and smoke from laboratory burning, exploring the variations and their causes. The speciation of phosphorus (P), calcium (Ca), and potassium (K) in fire ash from five globally distributed ecosystems was characterized by using X-ray absorption spectroscopy and sequential fractionation. Aqueous dissolution of the macronutrients was measured by batch experiments at acidic and alkaline pHs.

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Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis.

Brain

December 2024

Neuroimmunology Program, Fundació Clínic per la Recerca Biomèdica - Institut d'Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), Barcelona 08036, Spain.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies and animal models based on patients' antibody transfer or NMDAR immunization suggest that the autoantibodies play a major pathogenic role.

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The Softening of Persimmon Fruit Was Inhibited by Gibberellin via DkDELLA1/2.

J Agric Food Chem

December 2024

Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, Zhejiang 315100, China.

Texture is an important quality index reflecting a series of sensory evaluations of fruit, and softening is the main texture change of most postharvest fruit. Persimmon fruit () shows a pattern of decreasing firmness after harvest, leading to a short duration of sale and excessive waste. We found that the treatment with gibberellin (GA) could effectively inhibit the postharvest softening of persimmon fruit, but the underlying mechanism is unclear.

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PARP inhibitors (PARPi) have received regulatory approval for the treatment of several tumors, including prostate cancer (PCa), and demonstrate remarkable results in the treatment of castration-resistant prostate cancer (CRPC) patients characterized by defects in homologous recombination repair (HRR) genes. Preclinical studies showed that DNA repair genes (DRG) other than HRR genes may have therapeutic value in the context of PARPi. To this end, we performed multiple CRISPR/Cas9 screens in PCa cell lines using a custom sgRNA library targeting DRG combined with PARPi treatment.

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Aim: To assess for the first time the safety and feasibility of combining photon-IntraOperative RadioTherapy (ph-IORT) with hypofractionated whole-breast irradiation (hWBI) in patients referred to adjuvant radiotherapy after Breast-Conserving Surgery (BCS).

Methods: From February 2019 to August 2020, patients referred for breast-conserving surgery (BCS) in our institution were prospectively included in the present trial. BCS was discussed in the multidisciplinary tumor board (MTB).

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Michael Somogyi (Somogyi Mihály, 1883-1971) was a Hungarian biochemist who developed his scientific career in Europe and, primarily, the United States. He gave the name to the eponymous Somogyi effect or Somogyi hypothesis (in short, rebound hyperglycemia after insulin-induced hypoglycemia, particularly nocturnal), which was an axiom in the treatment of diabetes for decades. Although it is currently debated whether the Somogyi hypothesis is a real or relevant phenomenon in patients with diabetes, Somogyi's other significant career achievements are often overlooked.

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Recovery is a holistic approach to mental health care which focusses on the ability of people with mental disorders to achieve their goals and live full, meaningful lives despite their limitations. Recovery assessment tools are instruments that make it possible to measure the progress of people with mental disorders on their path to recovery. To explore, map and describe patient-reported outcome measures (PROMs) found in the literature related to the recovery process in people with mental disorders (MDs).

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Playing with the rope: a house sparrow behaviour related to its breeding activity.

Anim Cogn

December 2024

Departamento de Zoología, Facultad de Ciencias, Universidad de Granada, Granada, E-18071, Spain.

The house sparrow (Passer domesticus) is a gregarious generalist species, which makes it a good model for studying play. However, play has not been described for this species so far. We describe play behaviour in house sparrows for the first time, quantifying all play and play-related behaviours, searching for differences between the different sexes and ages, the possible association with reproductive success and the diffusion of this behaviour in the population.

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Aim: To describe the cortical brain development and full-IQ performance in middle school age children after extremely preterm (EPT) birth considering discrete white matter abnormalities (WMA). In addition, to assess possible early motor predictors of cortical brain development and full-IQ in children born EPT with and without discrete WMA diagnosed at 10 years.

Methods: T1-weighted MRI images from fifty-one children born before 27 weeks' gestation and 40 full-term born controls (M=10.

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Chiral Light-Matter Interactions with Thermal Magnetoplasmons in Graphene Nanodisks.

Nano Lett

December 2024

Instituto de Química Física Blas Cabrera (IQF), CSIC, 28006 Madrid, Spain.

We investigate the emergence of self-hybridized thermal magnetoplasmons in doped graphene nanodisks at finite temperatures upon being subjected to an external magnetic field. Using a semianalytical approach, which fully describes the eigenmodes and polarizability of the graphene nanodisks, we show that the hybridization originates from the coupling of transitions between thermally populated Landau levels and localized magnetoplasmon resonances of the nanodisks. Owing to their origin, these modes combine the extraordinary magneto-optical response of graphene with the strong field enhancement of plasmons, making them an ideal tool for achieving strong chiral light-matter interactions, with the additional advantage of being tunable through carrier concentration, magnetic field, and temperature.

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