The Role of Natriuretic Peptides in Pericardial Fluid in Predicting Cardiovascular Disorders: A Systematic Review.

Atrial and ventricular natriuretic peptides play an important role in the neurohormonal regulation of cardiac function. Plasma levels of these peptides may aid in the diagnosis and prognosis of different cardiac disorders, such as congestive heart failure, ischemic heart disease, and atrial fibrillation. However, the association between elevated pericardial fluid levels of natriuretic peptides and these clinical conditions has not been proven.

Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals.

The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.

Touch Empowerment: Self-Sustaining e-Tattoo Thermoelectric System for Temperature Mapping.

In recent advancements within sensing technology, driven by the Internet of Things (IoT), significant impacts are observed on health sector applications, notably through wearable electronics like electronic tattoos (e-tattoos). These e-tattoos, designed for direct contact with the skin, facilitate precise monitoring of vital physiological parameters, including body heat, a critical indicator for conditions such as inflammation and infection. Monitoring these indicators can be crucial for early detection of chronic conditions, steering toward proactive healthcare management.

Substance P and Neurokinin-1 receptor are overexpressed in adamantinomatous craniopharyngioma than in the pituitary gland.

Background: Human adamantinomatous craniopharyngioma (ACP) is a brain tumor that originates at the base of the skull and shows aggressive local behavior, invading sensitive structures such as the optic pathways and hypothalamus. The conventional treatment of the tumor has been surgery and radiotherapy with the consequent development of serious sequelae. It is well known that Substance P (SP) peptide and Neurokinin-1 receptor (NK-1R) are involved in inflammation and cancer progression and its blockage with NK-1R antagonists has been shown to effectively counteract tumor development in preclinical trials.

First evidence of predation on the native endangered Iberian desman (Galemys pyrenaicus) and Iberian water shrews (Neomys anomalus) by the invasive species American mink using eDNA tools in Extremadura (Spain).

Background: Wildlife conservation and management aims to restore population declines, it is the vulnerable or endangered populations who require the greatest conservation efforts. In this context, non-invasive sampling has been evaluated as an option for reporting prey/predator impact. Galemys pyrenaicus is currently threatened throughout its range, and cohabits with Nemys anomalus, in Extremadura (Spain).

Deciphering long-term immune effects of HIV-1/SARS-CoV-2 co-infection: a longitudinal study.

Introduction: While the general immune response to Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is well-understood, the long-term effects of Human Immunodeficiency Virus-1/Severe Acute Respiratory Syndrome-Coronavirus-2 (HIV-1/SARS-CoV-2) co-infection on the immune system remain unclear. This study investigates the immune response in people with HIV-1 (PWH) co-infected with SARS-CoV-2 to understand its long-term health consequences.

Methods: A retrospective longitudinal study of PWH with suppressed viral load and SARS-CoV-2 infection was conducted.

Novel method to investigate thermal exchange rates in small, terrestrial ectotherms: A proof-of-concept on the gecko Tarentola mauritanica.

Thermoregulating ectotherms may resort to different external heat sources to modulate their body temperature through an array of behavioural and physiological adaptations which modulate heat exchange with the environment and its distribution across the animal's body. Even small-bodied animals are capable of fine control over such rates and the subsequent re-allocation of heat across the body. Such thermal exchanges with the environment usually happen through two non-mutually exclusive modes: heliothermy (radiant heat gain from the sun) or thigmothermy (heat gained or lost via conduction).

Validation of step oncology, a platform for head and neck cancer patients support during and after treatment: preliminary results.

Purpose: Head and neck cancer (HNC) remains a significant global health concern with rising incidence and substantial impacts on patients' quality of life. Patients often experience adverse effects from both the disease and its treatment, affecting daily functions and social interactions. This study assesses the usability, interest, and satisfaction of HNC patients in using Step Oncology platform for improved treatment adherence and quality of life.

Is there any role for an atrial septal defect in off-loading a orderline left ventricle?

A_small_ASD_with right-to-left shunt is useful for off-loading a dysfunctional right ventricle postoperatively. However, an ASD with left-to-right shunt may not be as useful for a dysfunctional left ventricle. Experimental data is limited at present.

An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes.

At the end of cell division, the nuclear envelope reassembles around the decondensing chromosomes. Female meiosis culminates in two consecutive cell divisions of the oocyte, meiosis I and II, which are separated by a brief transition phase known as interkinesis. Due to the absence of chromosome decondensation and the suppression of genome replication during interkinesis, it has been widely assumed that the nuclear envelope does not reassemble between meiosis I and II.

Treatments and Treatment Predictors in Patients With Substance Use Disorders and Comorbid Attention-Deficit/Hyperactivity Disorder: First Results From the International Naturalistic Cohort Study of ADHD and SUD (INCAS).

Treatment of attention-deficit/ hyperactivity disorder (ADHD) in patients with a substance use disorder (SUD) and comorbid ADHD (SUD +ADHD) may have positive effects on the outcome of both conditions, but controversy exists regarding the preferred ADHD treatment in these patients. Little is known about the treatments that are provided for these patients in routine addiction care practice and the factors that are associated with treatment provision. To describe the treatments provided in everyday clinical practice and to explore factors associated with ADHD treatment provision in patients with SUD +ADHD.

First report of watermelon mosaic virus infecting faba bean ( L.) in China.

Faba bean (Vicia faba L.) is the fourth most cultivated temperate legume (Lyu et al., 2021).

Inclusive universities for students with intellectual disabilities from a teacher's perspective.

The aim of this research is to analyse the elements necessary for the construction of inclusive universities in the European context from the perspective of university professors. Three focus groups are conducted in different countries: Spain, Italy and Portugal. The discourses have been analysed following Grounded Theory.

Neuropsychiatric manifestations of sarcoidosis.

Background: There has been significant progress in understanding neurosarcoidosis (NS) as a distinct disorder, which encompasses a heterogeneous group of clinical and radiological alterations which can affect patients with systemic sarcoidosis or manifest isolated.

Rationale And Aim Of The Study: The healthcare challenges posed by NS and sarcoidosis in general extend beyond their physical symptoms and can include a variety of psychosocial factors, therefore the recognition of main neuropsychiatric symptoms can be useful to approach patients with NS. Methods: For this purpose, databases such as Pubmed, Medline and Pubmed Central (PMC) have been searched.

Synergy of Analytical Characterization and Biocompatible Extractions for the Enhancement of High-Quality Biorefinery Products from .

This study presents the development of an analytical characterization strategy tailored to end products derived from an alfalfa ()-based biorefinery with particular emphasis on protein concentrates and phenolic-enriched fractions. Our approach began with a comprehensive full-factorial experimental design aimed at optimizing the extraction process, taking care to design a biocompatible extraction protocol. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) techniques were used to characterize the molecular profile of the extracts.

Effect of an intensive lifestyle intervention on cystatin C-based kidney function in adults with overweight and obesity: From the PREDIMED-Plus trial.

Background: Large-scale trials evaluating a multicomponent lifestyle intervention aimed at weight loss on kidney function are lacking.

Methods: This was a post hoc analysis of the "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) randomized controlled trial, including patients with overweight/obesity and metabolic syndrome, measured cystatin C and creatinine. Participants were randomly assigned (1:1) to an intensive weight loss lifestyle intervention (intervention group [IG]) consisting of an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support, or a control group (CG) receiving ad libitum MedDiet recommendations.

Dual-targeted STAb-T cells secreting BCMA and CD19 T cell engagers for improved control of haematological cancers.

Despite recent advances in immunotherapy against B cell malignancies such as BCMA (B cell maturation antigen) and CD19-targeted treatments using soluble T cell-engaging (TCE) antibodies or chimeric antigen receptor T cells (CAR-T), there is still an important number of patients experiencing refractory/relapsed (R/R) disease. Approaches to avoid tumor-intrinsic mechanisms of resistance such as immune pressure-mediated antigen downmodulation, are being broadly investigated. These strategies include BCMA/CD19 dual-targeting therapies, which may be of particular interest to patients with B cell lymphoma and multiple myeloma, where a specific double-positive immature subpopulation is commonly associated with poor prognosis and poor response to current treatments.

Artificial intelligence virtual assistants in primary eye care practice.

Purpose: To propose a novel artificial intelligence (AI)-based virtual assistant trained on tabular clinical data that can provide decision-making support in primary eye care practice and optometry education programmes.

Method: Anonymised clinical data from 1125 complete optometric examinations (2250 eyes; 63% women, 37% men) were used to train different machine learning algorithm models to predict eye examination classification (refractive, binocular vision dysfunction, ocular disorder or any combination of these three options). After modelling, adjustment, mining and preprocessing (one-hot encoding and SMOTE techniques), 75 input (preliminary data, history, oculomotor test and ocular examinations) and three output (refractive, binocular vision status and eye disease) features were defined.