A novel peptide CP29L, selected from the phage displayed cyclic random heptapeptide library, demonstrates its potent inhibitory effects to liver cancer HCCLM3 cells by targeting FOXM1.

FOXM1 is the "Achilles' heel" of cancers and hence the potential therapeutic target for anticancer drug discovery. In this work, we selected high affinity peptides against the protein of human DNA binding domain of FOXM1 (FOXM1-DBD) from the disulfide-constrained, phage displayed random cyclic heptapeptide library Ph.D.

Nidustrin A, cysteine-retained emestrin with a unique 18-membered macrocyclic lactone from the endophytic fungus Aspergillus nidulans.

Nidustrin A (1), the first cysteine-retained emestrin featuring a unique sulfur-containing 18-membered macrocyclic lactone, along with four biogenetically related compounds (2-5), and one known analogue secoemestrin C (6), were isolated from the large-scale culture of Aspergillus nidulans, an endophytic fungus derived from the Whitmania pigra. Compounds 2 and 3 represent the second examples of noremestrin besides the previously reported noremestrin A, and the single crystal X-ray diffraction analysis of compound 2 provided solid evidence for the intriguing skeleton of noremestrin. Their structures were determined by extensive spectroscopic data, electronic circular dichroism calculations, and single-crystal X-ray diffraction.

Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications.

Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential for maintaining cellular homeostasis. RES promotes the initiation and execution of mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, and mitigating apoptosis, thereby preserving mitochondrial integrity.

Exploring the incidence and influencing factors of postoperative nausea and vomiting after laparoscopic bariatric surgery: a protocol for a retrospective observational study.

Introduction: The global prevalence of obesity and its associated comorbidities is rising, with bariatric surgery emerging as a highly efficacious intervention for obese patients. Postoperative nausea and vomiting (PONV) is a common complication following bariatric surgery, with a standardised protocol for its prevention and management yet to be established. This study aims to determine the incidence and the influencing factors of PONV following various types of bariatric surgeries, thereby facilitating the targeted prevention strategies.

Anisotropic Nanofluidic Ionic Skin for Pressure-Independent Thermosensing.

Ionic skin can mimic human skin to sense both temperature and pressure simultaneously. However, a significant challenge remains in creating precise ionic skins resistant to external stimuli interference when subjected to pressure. In this study, we present an innovative approach to address this challenge by introducing a highly anisotropic nanofluidic ionic skin (ANIS) composed of carboxylated cellulose nanofibril (CNF)-reinforced poly(vinyl alcohol) (PVA) nanofibrillar network achieved through a straightforward one-step hot drawing method.

Tracking the correlation between spintronic structure and oxygen evolution reaction mechanism of cobalt-ruthenium-based electrocatalyst.

Regulating the spintronic structure of electrocatalysts can improve the oxygen evolution reaction performance efficiently. Nonetheless, the effects of tuning the spintronic structure for the oxygen evolution reaction mechanisms have rarely been discussed. Here, we show a ruthenium-cobalt-tin oxide with optimized spintronic structure due to the quantum spin interaction of Ru and Co.

Moisture-based green energy harvesting over 600 hours via photocatalysis-enhanced hydrovoltaic effect.

Harvesting the energy from the interaction between hygroscopic materials and atmospheric water can generate green and clean energy. However, the ion diffusion process of moisture-induced dissociation leads to the disappearance of the ion concentration gradient gradually, and there is still a lack of moisture-based power generation devices with truly continuous operation, especially the duration of the current output still needs to be extended. Here, we propose a design for reconstructing the ion concentration gradient by coupling photocatalytic hydrogen evolution reaction with hydrovoltaic effect, to report a moisture-enabled electric generator (MEG) with continuous current output.

Spontaneous bifacial capping of perovskite film for efficient and mechanically stable flexible solar cell.

Flexible perovskite solar cells (F-PSCs) are appealing for their flexibility and high power-to-weight ratios. However, the fragile grain boundaries (GBs) in perovskite films can lead to stress and strain cracks under bending conditions, limiting the performance and stability of F-PSCs. Herein, we show that the perovskite film can facilely achieve in situ bifacial capping via introducing 4-(methoxy)benzylamine hydrobromide (MeOBABr) as the precursor additive.

Lateral flow analysis test strips based on aggregation-induced emission technique: Principle, design, and application.

This review examines the potential of aggregation-induced luminescence (AIE) materials in lateral flow assays (LFA) to enhance the sensitivity and specificity of a range of assay applications. LFA is a straightforward and effective paper-based platform for the rapid detection of target analytes in mixtures. Its simple design, low cost, and ease of operation are among the most attractive advantages of LFA.

Tunable band gaps and conduction band edges of CdS/ZnS heterostructures - a first-principles-based prediction.

CdS/ZnS heterostructures with tunable band gaps are promising photocatalysts for solar- or visible-light-driven H production through water splitting. To predict how the bandgap changes with the heterostructure composition, density functional theory calculations with meta-GGA correction are performed. It is found that the band gaps of CdS and ZnS are reduced by up to 14.

Driver's journey from historical traffic violations to future accidents: A China case based on multilayer complex network approach.

Traffic violation records serve as key indicators for predicting drivers' future accidents. However, beyond statistical correlations, the underlying mechanisms linking historical traffic violations to future accidents remain inadequately understood. This study introduces a research framework to address this gap: Using Propensity Score Matching and an adapted mutual information-based feature selection algorithm to precisely identify correlations and optimal time windows between drivers' historical traffic violations and future accidents.

Impact of Prolonged Cycle Length Resulting From Conversion of Atrial Fibrillation to Atrial Tachycardia on Ablation Outcome in Persistent Atrial Fibrillation Ablation.

There is limited available data regarding the impact of cycle length (CL) prolongation when converting atrial fibrillation (AF) to organized atrial tachycardia (AT) and its effect on clinical outcomes. We retrospectively screened and included a cohort of 132 patients with persistent or long-standing persistent AF who underwent circumferential pulmonary vein isolation (CPVI) and left atrial substrate modification (LASM) between January 2015 and October 2019. In all 132 consecutive patients, persistent AF was successfully converted into organized AT.

Atrial Fibrillation Termination as a Predictor for Persistent Atrial Fibrillation Ablation: A Systemic Review and Meta-Analysis of Prospective Studies.

In this systematic review and meta-analysis, we aimed to validate the predictive role of atrial fibrillation (AF) termination in long-term arrhythmia recurrence. Our search encompassed databases including MEDLINE, EMBASE, PubMed, and the Cochrane Library up to August 1, 2021. Three independent reviewers conducted screening and data extraction.

Evolutionary analysis of slope direction deformation in the Gaojiawan landslide based on time-series InSAR and Kalman filtering.

The existing landslide monitoring methods are unable to accurately reflect the true deformation of the landslide body, and the use of a single SAR satellite, affected by its revisit cycle, still suffers from the limitation of insufficient temporal resolution for landslide monitoring. Therefore, this paper proposes a method for the dynamic reconstruction and evolutionary characteristic analysis of the Gaojiawan landslide's along-slope deformation based on ascending and descending orbit time-series InSAR observations using Kalman filtering. Initially, the method employs a gridded selection approach during the InSAR time-series processing, filtering coherent points based on the standard deviation of residual phases, thereby ensuring the density and quality of the extracted coherent points.

Machine Learning Prediction of Early Recurrence in Gastric Cancer: A Nationwide Real-World Study.

Background: Patients with gastric cancer (GC) who experience early recurrence (ER) within 2 years postoperatively have poor prognoses. This study aimed to analyze and predict ER after curative surgery for patients with GC using machine learning (ML) methods.

Patients And Methods: This multicenter population-based cohort study included data from ten large tertiary regional medical centers in China.

All-polymer piezo-ionic-electric electronics.

Piezoelectric electronics possess great potential in flexible sensing and energy harvesting applications. However, they suffer from low electromechanical performance in all-organic piezoelectric systems due to the disordered and weakly-polarized interfaces. Here, we demonstrated an all-polymer piezo-ionic-electric electronics with PVDF/Nafion/PVDF (polyvinylidene difluoride) sandwich structure and regularized ion-electron interfaces.

Removal of sulfamethoxazole by Fe(III)-activated peracetic acid combined with ascorbic acid.

Ascorbic acid (AA) was used as a reducing agent to improve the Fe(III)-activated peracetic acid (PAA) system for the removal of sulfamethoxazole (SMX) in this work. The efficiency, influencing factors and mechanism of SMX elimination in the AA/Fe(III)/PAA process were studied. The results exhibited that AA facilitated the reduction of Fe(III) to Fe(II) and subsequently improved the activation of PAA and HO.

Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy.

Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment's (TIME) complexity and heterogeneity challenge tumor immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility and drug release control, which is widely used in drug delivery, agriculture, industry, etc.

A ceramic microbridge microfluidic chip to study osteogenic differentiation of mesenchymal stem cells in bioactive ceramic immune microenvironment.

Bioactive ceramics have been used in bone tissue repair and regeneration. However, because of the complex in vivo osteogenesis process, long cycle, and difficulty of accurately tracking, the mechanism of interaction between materials and cells has yet to be fully understood, hindering its development. The ceramic microbridge microfluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo.

The Role of Sex Hormones and Sex Hormone-binding Globulin in Functional Gatrointestinal Disorders: A Bidirectional Two-sample Mendelian Randomization Study.

Background And Aims: Sex hormones and sex hormone-binding globulin (SHBG) have been confirmed to involve in the pathophysiology of functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome (IBS) and functional dyspepsia (FD). However, causal associations have not yet been investigated. Utilizing data from Genome-wide association studies, we conducted bidirectional two-sample mendelian randomization (MR) analyses to assess the causal relationships between sex hormones, SHBG and FGIDs.

Prediction of change in suitable habitats of Senna obtusifolia and Senna tora under climate change.

Senna obtusifolia (L.) Irwin & Barneby and Senna tora (L.) Roxb represent important medicinal resources in traditional Chinese medicine for more than two millennia.

Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization.

The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a self-developed questionnaire (dataset 2) and obtained dataset 1 from the 2021 China General Social Survey (CGSS).