[Combination of chronic obstructive pulmonary disease and arterial hypertension in the elderly: clinical and hemodynamic features and quality of life.].

Clinical features, hemodynamics and quality of life of elderly patients with a combination of chronic obstructive pulmonary disease and arterial hypertension were assessed. The results of the study suggest that in the case of a combination of arterial hypertension and chronic lung disease, not only distinct clinical, functional and hemodynamic changes are observed, but also a significant decrease in the quality of life, largely determined by the severity of the symptoms of both diseases, as well as the severity of the comorbid pathology. The revealed changes in elderly patients with chronic obstructive pulmonary disease and arterial hypertension dictate the need to optimize, first of all, the outpatient stage of observation and rehabilitation of elderly patients with comorbid pathology.

Calcium Dynamics of the Ventrolateral Preoptic GABAergic Neurons during Spontaneous Sleep-Waking and in Response to Homeostatic Sleep Demands.

The ventrolateral preoptic area (VLPO) contains GABAergic sleep-active neurons. However, the extent to which these neurons are involved in expressing spontaneous sleep and homeostatic sleep regulatory demands is not fully understood. We used calcium (Ca) imaging to characterize the activity dynamics of VLPO neurons, especially those expressing the vesicular GABA transporter (VGAT) across spontaneous sleep-waking and in response to homeostatic sleep demands.

Novel Indoline Spiropyrans Based on Human Hormones β-Estradiol and Estrone: Synthesis, Structure, Chromogenic and Cytotoxic Properties.

The introduction of a switchable function into the structure of a bioactive compound can endow it with unique capabilities for regulating biological activity under the influence of various types of external stimuli, which makes such hybrid compounds promising objects for photopharmacology, targeted drug delivery and bio-imaging. This work is devoted to the synthesis and study of new spirocyclic derivatives of important human hormones-β-estradiol and estrone-possessing a wide range of biological activities. The obtained hybrid compounds represent an indoline spiropyrans family, a widely known class of organic photochromic compounds.

Changes of dorsoventral asymmetry and anoxygenic photosynthesis in response of leaves to the SiO nanoparticle treatment.

Natural SiO nanoparticles (SiO-NPs) are widely distributed in the environment, and at the same time, synthetic SiO-NP may be applied in agriculture. Evaluations of physiological responses to SiO-NPs treatment of plants are controversial. They are often performed at adaxial leaf sides whereas NPs permeate leaf tissues through stomata located at the abaxial leaf side in the majority of bifacial plants.

New approach to soil management focusing on soil health and air quality: one earth one life (critical review).

Soil plays a key role in ecosphere and air quality regulation. Obsolete environmental technologies lead to soil quality loss, air, water, and land systems pollution. Pedosphere and plants are intertwined with the air quality.

Enzymatic Assessment of the State of Oil-Contaminated Soils in the South of Russia after Bioremediation.

Soil pollution with oil as a result of accidents at oil pipelines and oil refineries is a frequent occurrence in the south of Russia. To restore such polluted lands, it is necessary to carry out soil remediation measures. This work aimed to evaluate the use of ameliorants of various natures (biochar, sodium humate, and microbial preparation Baikal EM-1) to restore the ecological state of oil-contaminated soils with different properties (Haplic Chernozem, Haplic Arenosols, Haplic Cambisols).

Nanoparticles-Based Delivery Systems for Salicylic Acid as Plant Growth Stimulator and Stress Alleviation.

The population growth tendency leads to an increase in demand for food products, and in particular, products obtained from the processing of plants. However, there are issues of biotic and abiotic stresses that can significantly reduce crop yields and escalate the food crisis. Therefore, in recent years, the development of new methods of plant protection became an important task.

A novel hybrid protein composed of superoxide-dismutase-active Cu(II) complex and lysozyme.

A novel hybrid protein composed of a superoxide dismutase-active Cu(II) complex (CuST) and lysozyme (CuST@lysozyme) was prepared. The results of the spectroscopic and electrochemical analyses confirmed that CuST binds to lysozyme. We determined the crystal structure of CuST@lysozyme at 0.

The Role of Genetic Variants in the Long Non-Coding RNA Genes and in the Pathogenesis of Childhood Obesity.

Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Imprinted Maternally Expressed Transcript (H19), might participate in the pathogenesis of metabolic disorders such as obesity. We conducted a case-control study with 150 Russian children and adolescents aged between 5 and 17 years old in order to assess the statistical association between the single nucleotide polymorphisms (SNPs) rs3200401 in and rs217727 in , and the risk of developing obesity in this population.

Uptake, accumulation, toxicity, and interaction of metallic-based nanoparticles with plants: current challenges and future perspectives.

The rapid development of industrialization is causing several fundamental problems in plants due to the interaction between plants and soil contaminated with metallic nanoparticles (NPs). Numerous investigations have been conducted to address the severe toxic effects caused by nanoparticles in the past few decades. Based on the composition, size, concentration, physical and chemical characteristics of metallic NPs, and plant types, it enhances or lessens the plant growth at various developmental stages.

Assessment of soil development during rapid urbanization using the carbon and nitrogen stable isotope composition.

The proposed paper is devoted to the analysis of the urbanization effects on soil cover using physico-chemical parameters and stable isotopic signatures on the example of Tyumen. The study methods included analysis of C and N elemental and isotope (δC and δN) composition, analysis of soil physico-chemical properties and major oxides content. The results of the survey have shown that soil properties within the city limits vary significantly depending on both anthropogenic activities and geomorphological context.

Quantitative Structural Description of Zeolites by Machine Learning Analysis of Infrared Spectra.

Application of machine learning (ML) algorithms to spectroscopic data has a great potential for obtaining hidden correlations between structural information and spectral features. Here, we apply ML algorithms to theoretically simulated infrared (IR) spectra to establish the structure-spectrum correlations in zeolites. Two hundred thirty different types of zeolite frameworks were considered in the study whose theoretical IR spectra were used as the training ML set.

New cationic spiropyrans with photoswitchable NIR fluorescence.

Visible-light-mediated photochromic compounds with NIR absorption and fluorescence are of great interest for use in different biomedical applications. In this work, new representatives of spiropyrans with conjugated cationic 3H-indolium substituents in different positions of 2H-chromene moiety were synthesized. The electron-donating methoxy groups were introduced in the uncharged indoline and charged indolium cycles to form the effective conjugation chain between the hetarene moiety and the cationic fragment for reaching NIR absorption and fluorescence.

Discovery of Novel EGFR Inhibitor Targeting Wild-Type and Mutant Forms of EGFR: In Silico and In Vitro Study.

Targeting L858R/T790M and L858R/T790M/C797S mutant EGFR is a critical challenge in developing EGFR tyrosine kinase inhibitors to overcome drug resistance in non-small cell lung cancer (NSCLC). The discovery of next-generation EGFR tyrosine kinase inhibitors (TKIs) is therefore necessary. To this end, a series of furopyridine derivatives were evaluated for their EGFR-based inhibition and antiproliferative activities using computational and biological approaches.

Editorial for Special Issue "Nano-Bioremediation Approaches for Degraded Soils and Sustainable Crop Production".

In recent decades, the global population has rapidly increased, resulting in an increasing demand for food [...

Photothermal Effect and Phase Transition in VO Enhanced by Plasmonic Particles.

Phase change metasurfaces based on VO, which are pre-heated with electric current and optically addressed by projected structured light hologram, are considered to become a new paradigm in programmed THz/middle IR flat optics. Macroscopic quasi-homogeneous arrays of Au nanoparticles show large near IR absorption and a significant photothermal effect capable of boosting a light-triggered switching of VO and are to be carefully examined. We propose a new approach to simultaneously probe the altered temperature and electric conductivity of a hybrid Au particle-VO film composite by monitoring a phase shift and attenuating a surface acoustic wave in a YX128° cut LiNbO substrate.

Investigating the Biochemical Responses in Wheat Cultivars Exposed to Thermal Power Plant Emission.

The current study aimed to assess how high concentrations of ozone (O) and suspended particulate matter (SPM) alter biochemical properties of high yielding wheat cultivars (i.e., HD3086 and HD2967) grown under 10 km radius in 8 villages, located around Thermal Power Plant (TPP), Auraiya, Uttar Pradesh, India.

Activity and Interconnections of Individual and Collective Actors: An Integrative Approach to Small Group Research.

In this article, we attempted to integrate and further develop theoretical ideas in the area of the small group research about all group activity levels (types of actors) - individual, informal subgroup, and group - and about connections among them. We have touched upon such issues as (a) modes of group activity represented by activities of each type of the actors; (b) structural and functional associations among the actors; (c) functions that each type of actors carries out with respect to another type of actors; (d) direct and indirect links among actors; (e) the influence of links between some actors on links among other actors; and (f) processes of integration and disintegration as the main mechanism for changing connections among actors. Special attention is paid to direct (immediate) personalized and depersonalized connections among actors, as well as to connections mediated by actors' connections with another actor or some object.

Nanomaterials in biochar: Review of their effectiveness in remediating heavy metal-contaminated soils.

Biochar can be used for soil remediation in environmentally beneficial manner, especially when combined with nanomaterials. After a decade of research, still, no comprehensive review was conducted on the effectiveness of biochar-based nanocomposites in controlling heavy metal immobilization at soil interfaces. In this paper, the recent progress in immobilizing heavy metals using biochar-based nanocomposite materials were reviewed and compared their efficacy against that of biochar alone.

Synthesis, conformational stability and molecular structure of 4-aryl- and 4,5-diaryl-1,8-bis(dimethylamino)naphthalenes.

4-Bromo- and 4,5-dibromo-1,8-bis(dimethylamino)naphthalenes were arylated with arylboronic acids under Suzuki reaction conditions to provide 4-aryl- and 4,5-diaryl-1,8-bis(dimethylamino)naphthalenes, respectively. The interaction of 4,5-dibromo-1,8-bis(dimethylamino)naphthalene with pyridin-3-ylboronic acid was accompanied by heterocyclization leading unexpectedly to the formation of ,,,-tetramethylacenaphtho[1,2-]pyridine-3,4-diamine. Dynamic H NMR experiments showed fast interconversion between and conformers of 4,5-diaryl-1,8-bis(dimethylamino)naphthalenes in CDCl solution at room temperature.

Potential medicinal plants to combat viral infections: A way forward to environmental biotechnology.

The viral diseases encouraged scientific community to evaluate the natural antiviral bioactive components rather than protease inhibitors, harmful organic molecules or nucleic acid analogues. For this purpose, medicinal plants have been gaining tremendous importance in the field of attenuating the various kinds of infectious and non-infectious diseases. Most of the commonly used medicines contains the bioactive components/phytoconstituents that are generally extracted from medicinal plants.

New Self-Healing Metallosupramolecular Copolymers with a Complex of Cobalt Acrylate and 4'-Phenyl-2,2':6',2″-terpyridine.

Currently, the chemistry of self-healing polymers is aimed not only at obtaining materials with high self-healing efficiency, but also at improving their mechanical performance. This paper reports on a successful attempt to obtain self-healing copolymers films of acrylic acid, acrylamide and a new metal-containing complex of cobalt acrylate with a 4'-phenyl-2,2':6',2″-terpyridine ligand. Samples of the formed copolymer films were characterized by ATR/FT-IR and UV-vis spectroscopy, elemental analysis, DSC and TGA, SAXS, WAXS and XRD studies.

Fish Probiotics: Cell Surface Properties of Fish Intestinal Lactobacilli and .

The properties of intestinal bacteria/probiotics, such as cell surface hydrophobicity (CSH), auto-aggregation, and biofilm formation ability, play an important role in shaping the relationship between the bacteria and the host. The current study aimed to investigate the cell surface properties of fish intestinal bacteria and probiotics. Microbial adhesion to hydrocarbons was tested according to Kos and coauthors.

Study of the Possibility of Using Sol-Gel Technology to Obtain Magnetic Nanoparticles Based on Transition Metal Ferrites.

The article presents results for the magnetic nanoparticles sol-gel method synthesis of cobalt (II) ferrite and organic-inorganic composite materials based on it. The obtained materials were characterized using X-ray phase analysis, scanning and transmission electron microscopy, Scherrer, Brunauer-Emmett-Teller (BET) methods. A composite materials formation mechanism is proposed, which includes a gelation stage where transition element cation chelate complexes react with citric acid and subsequently decompose under heating.