4 results match your criteria: "Southern University of Science and TechnologyShenzhen[Affiliation]"

Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse Cochlea.

Front Mol Neurosci

July 2017

Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast UniversityNanjing, China.

Lgr5+ supporting cells (SCs) are enriched hair cell (HC) progenitors in the cochlea. Both and studies have shown that HC injury can spontaneously activate Lgr5+ progenitors to regenerate HCs in the neonatal mouse cochlea. Promoting HC regeneration requires the understanding of the mechanism of HC regeneration, and this requires knowledge of the key genes involved in HC injury-induced self-repair responses that promote the proliferation and differentiation of Lgr5+ progenitors.

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Article Synopsis
  • Crenarchaeol is primarily produced by Thaumarchaeota, but other archaeal groups like Thermoplasmatales and methanogens may also contribute to its presence in various ecosystems.
  • The study analyzed soil and sediment samples to understand the relationship between archaeal communities and different forms of iGDGT lipids, particularly in relation to crenarchaeol.
  • Findings indicate that while Thaumarchaeota are the main source of crenarchaeol, the presence and abundance of Thermoplasmatales and methanogens can also play a role, suggesting a more complex evolutionary background for lipid synthesis in archaea.
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Temperature, nutrients, and salinity are among the important factors constraining the distribution and abundance of microorganisms in the ocean. Marine Group II (MGII) belonging to Euryarchaeota commonly dominates the planktonic archaeal community in shallow water and Marine Group I (MGI, now is called Thaumarchaeota) in deeper water in global oceans. Results of quantitative PCR (qPCR) and 454 sequencing in our study, however, showed the dominance of MGII in planktonic archaea throughout the water column of the northeastern South China Sea (SCS) that is characterized by strong water mixing.

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Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea.

Front Mol Neurosci

April 2017

Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast UniversityNanjing, China.

Cochlear supporting cells (SCs) have been shown to be a promising resource for hair cell (HC) regeneration in the neonatal mouse cochlea. Previous studies have reported that Lgr5+ SCs can regenerate HCs both and and thus are considered to be inner ear progenitor cells. Lgr5+ progenitors are able to regenerate more HCs than Lgr5- SCs, and it is important to understand the mechanism behind the proliferation and HC regeneration of these progenitors.

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