1 results match your criteria: "Southern University of Science and Technology Taizhou Research Institute[Affiliation]"
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis.
Transl Res
November 2024
The First Affiliated Hospital, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China; Comprehensive Health Industry Research Center, Southern University of Science and Technology Taizhou Research Institute, Taizhou 318000, China. Electronic address:
Article Synopsis
- Extrachromosomal circular DNA (eccDNA) from linear chromosomes shows a nucleosomal ladder pattern and is associated with apoptosis and immunogenicity in systemic lupus erythematosus (SLE) patients.
- In SLE patients, increased levels of cell-free DNA (cfDNA) are present, with eccDNA being less common and challenging to detect, and its role and characteristics in plasma remain unclear.
- This study identified that eccDNA in SLE has lower counts and GC content compared to healthy individuals, correlates with specific antibodies, and is enriched in apoptosis-related pathways; eccDNA may also act as a novel autoantigen contributing to SLE's pathogenesis.