Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo.

Vertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue.

Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up.

Biomarkers of ageing (BA) can predict health risks beyond chronological age, but little is known about how marital/living status affects longitudinal changes in BA. We examined the association between marital/living status and BA over time using the-Swedish-Adoption/Twin-Study-of-Aging (SATSA) cohort. Four BAs were analyzed: telomere length (TL) (638 individuals; 1603 measurements), DNAmAge (535 individuals; 1392 measurements), cognition (823 individuals; 3218 measurements), and frailty index (FI) (1828 individuals; 9502 measurements).

Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study.

Background: Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, and programmed cell death (PCD) is increasingly recognized as a potential target in cancer therapy and prognosis. However, a PCD-based predictive model for serous ovarian carcinoma (SOC) is lacking. In the present study, we aimed to establish a cell death index (CDI)-based model using PCD-related genes.

Knowledge, attitude, and practice toward vocal fatigue among occupational voice users: a cross-sectional study.

Background: Occupational voice users frequently face the challenge of vocal fatigue, impacting their overall well-being and job performance. This study aimed to investigate the knowledge, attitude, and practice (KAP) toward vocal fatigue among occupational voice users.

Methods: This web-based cross-sectional study was conducted among occupational voice users between July and October 2023 in Shenzhen People's Hospital, utilizing a self-administered questionnaire to examine the KAP of vocal fatigue.

Disorder-order transition-induced unusual bandgap bowing effect of tin-lead mixed perovskites.

Owing to the predominant merit of tunable bandgaps, tin-lead mixed perovskites have shown great potentials in realizing near-infrared optoelectronics and are receiving increasing attention. However, despite the merit, there is still a lack of fundamental understanding of the bandgap variation as a function of Sn/Pb ratio, mainly because the films are easy to segregate in terms of both composition and phase. Here, we report a fully stoichiometric synthesis of monocrystalline FAPbSnI nanocrystals as well as their atomic-scale imaging.

Non-adapted bacterial infection suppresses plant reproduction.

Environmental stressors, including pathogens, substantially affect the growth of host plants. However, how non-adapted bacteria influence nonhost plants has not been reported. Here, we reveal that infection of flowers by pv.

Reducing Disorder in PbTe Nanowires for Majorana Research.

Material challenges are the key issue in Majorana research, where surface disorder constrains device performance. Here, we tackle this challenge by embedding PbTe nanowires within a lattice-constant-matched crystal. The wire edges are shaped by self-organized growth instead of lithography, resulting in nearly atomically flat facets along both cross-sectional and longitudinal directions.

Engineered Therapeutic Bacteria with High-Yield Membrane Vesicle Production Inspired by Eukaryotic Membrane Curvature for Treating Inflammatory Bowel Disease.

Bacterial membrane vesicles (BMVs) are emerging as powerful natural nanoparticles with transformative potential in medicine and industry. Despite their promise, scaling up BMV production and ensuring stable isolation and storage remain formidable challenges that limit their broader application. Inspired by eukaryotic mechanisms of membrane curvature, we engineered DH5α to serve as a high-efficiency BMV factory.

Human Health Risk Assessment of Chlorinated Hydrocarbons in Groundwater Based on Multi-Pathway Analysis.

The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety. However, there has been insufficient assessment of the health risks posed by chlorinated hydrocarbon contamination in groundwater around chemical industrial parks. This study evaluates the chlorinated hydrocarbon contamination in groundwater at a chemical park and conducts a multi-pathway health risk assessment, identifying the key risk pollutants.

The Association of Dietary Polyamines with Mortality and the Risk of Cardiovascular Disease: A Prospective Study in UK Biobank.

Background: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD).

Methods: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire.

Bayesian Regression Analysis for Dependent Data with an Elliptical Shape.

This paper proposes a parametric hierarchical model for functional data with an elliptical shape, using a Gaussian process prior to capturing the data dependencies that reflect systematic errors while modeling the underlying curved shape through a von Mises-Fisher distribution. The model definition, Bayesian inference, and MCMC algorithm are discussed. The effectiveness of the model is demonstrated through the reconstruction of curved trajectories using both simulated and real-world examples.

Construction of a Dataset for All Expressed Transcripts for Alzheimer's Disease Research.

Accurate identification and functional annotation of splicing isoforms and non-coding RNAs (lncRNAs), alongside full-length protein-encoding transcripts, are critical for understanding gene (mis)regulation and metabolic reprogramming in Alzheimer's disease (AD). This study aims to provide a comprehensive and accurate transcriptome resource to improve existing AD transcript databases. : Gene mis-regulation and metabolic reprogramming play a key role in AD, yet existing transcript databases lack accurate and comprehensive identification of splicing isoforms and lncRNAs.

How does globally accumulated tropical cyclone energy vary in response to a changing climate?

How tropical cyclone (TC) activity varies in response to a changing climate is widely debated. The accumulated cyclone energy (ACE) is one of the indicators of TC activity and has attracted considerable attention because of its close relationship with the damages caused by TCs. Previous studies have focused on detecting long-term trends in global ACE; however, the results are inconclusive.

Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant -induced pulmonary infection.

() commonly induces refractory infection due to its multidrug-resistant nature. To date, there have been no reports on the application of phage treatment for infection. This study was conducted to explore the feasibility of phage application in treating refractory infection by collaborating with a 59-year-old male patient with a pulmonary infection of multidrug-resistant Our experiments included three domains: ) selection of the appropriate phage, ) verification of the efficacy and safety of the selected phage, ) confirmation of phage-bacteria interactions.

Terahertz Saturable Absorption across Charge Separation in Photoexcited Monolayer Graphene/MoS Heterostructure.

Unveiling the nonlinear interactions between terahertz (THz) electromagnetic waves and free carriers in two-dimensional materials is crucial for the development of high-field and high-frequency electronic devices. Herein, we investigate THz nonlinear transport dynamics in a monolayer graphene/MoS heterostructure using time-resolved THz spectroscopy with intense THz pulses as the probe. Following ultrafast photoexcitation, the interfacial charge transfer establishes a nonequilibrium carrier redistribution, leaving free holes in the graphene and trapping electrons in the MoS.

Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data.

Background: The present study aimed to explore the threshold-effect association of serum ferritin levels with type 2 diabetes mellitus (T2DM) and prediabetes mellitus in Chinese adults.

Methods: A total of 8365 people from CHNS a cross-sectional survey in 2009 were finally included. The biomarker data, including major cardiovascular biomarkers and important nutrition biomarkers were collected.

DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells.

The mechanism by which DNA-damage affects self-renewal and pluripotency remains unclear. DNA damage and repair mechanisms have been largely elucidated in mutated cancer cells or simple eukaryotes, making valid interpretations on early development difficult. Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs).

Low-threshold surface-emitting colloidal quantum-dot circular Bragg laser array.

Colloidal quantum dots (CQDs) are attractive gain media due to their wavelength-tunability and low optical gain threshold. Consequently, CQD lasers, especially the surface-emitting ones, are promising candidates for display, sensing and communication. However, it remains challenging to achieve a low-threshold surface-emitting CQD laser array with high stability and integration density.

Catalytic asymmetric C-N cross-coupling towards boron-stereogenic 3-amino-BODIPYs.

3-Amino boron dipyrromethenes (BODIPYs) are a versatile class of fluorophores widely utilized in live cell imaging, photodynamic therapy, and fluorescent materials science. Despite the growing demand for optically active BODIPYs, the synthesis of chiral 3-amino-BODIPYs, particularly the catalytic asymmetric version, remains a challenge. Herein, we report the synthesis of boron-stereogenic 3-amino-BODIPYs via a palladium-catalyzed desymmetric C-N cross-coupling of prochiral 3,5-dihalogen-BODIPYs.

Stacking ferroelectricity in two-dimensional van der Waals materials.

Miniaturization of ferroelectrics for technological applications has proven challenging due to the suppression of electric polarization caused by increasing depolarization fields as material thickness decreases. The emergence of ferroelectricity in two-dimensional (2D) van der Waals (vdW) materials offers a potential solution to this challenge, prompting significant research efforts over the past decade. While intrinsic 2D vdW ferroelectrics are scarce, polar stacking provides a more general approach to introducing ferroelectricity in these materials.

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis.

Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders our understanding of the pathogenesis of osteoarthritis (OA). Here, we constructed a single-cell transcriptomic atlas of chondrocytes in healthy cartilage and identified nine chondrocyte subsets including homeostatic chondrocytes, proliferate fibrochondrocytes, and hypertrophic chondrocytes (HTC).

Molecular recognition of the promoter DNA signature sequence by Hms1p.

Transcriptional regulation of sterol biosynthetic genes is mediated by conserved sterol-regulatory element binding proteins (SREBPs) in human pathogenic fungi, however, its homolog in S. cerevisiae regulate filamentous growth during stress conditions. These pseudohyphal growths might be associated with the expression of MEP2 gene in response to ammonium limitation.