451 results match your criteria: "Southern Medical University the First People's Hospital of Shunde[Affiliation]"

Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study.

Clin Gastroenterol Hepatol

June 2024

Department of Gastroenterology, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China; Biomedical Innovation Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China. Electronic address:

Background & Aims: Previous studies confirm vonoprazan-amoxicillin effectiveness for Helicobacter pylori. This study aims to investigate vonoprazan with varying amoxicillin dose and duration.

Methods: This multicenter, prospective, randomized controlled, noninferiority trial enrolled patients with treatment naive H pylori infection from 5 clinical centers.

View Article and Find Full Text PDF

Background: Previous epidemiological investigations and related research efforts consistently have outlined an observable association between anxiety disorders and adhesive capsulitis (AC). However, the intricate nature of the causal connection between these entities has yet to be fully clarified. Therefore, this investigative study aims to thoroughly examine and delineate the causal interrelationship between anxiety disorders and AC using a bidirectional, two-sample Mendelian randomization (MR) approach.

View Article and Find Full Text PDF

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance against chemotherapy and immunotherapy due to its dense desmoplastic and immunosuppressive tumor microenvironment (TME). Traditional photodynamic therapy (PDT) was also less effective for PDAC owing to poor selectivity, insufficient penetration, and accumulation of photosensitizers in tumor sites. Here, we designed a light-responsive novel nanoplatform targeting the TME of PDAC through tumor-specific midkine nanobodies (Nbs), which could efficiently deliver semiconducting polymeric nanoparticles (NPs) to the TME of PDAC and locally produce abundant reactive oxygen species (ROS) for precise photoimmunotherapy.

View Article and Find Full Text PDF

Spätzle maintains homeostasis of hemolymph microbiota in Scylla paramamosain through Toll2.

Fish Shellfish Immunol

March 2024

Guangdong Provincial Key Laboratory of Marine Biology, Institute of Marine Sciences, Shantou University, Shantou, China. Electronic address:

The Toll pathway is crucial for innate immune responses in organisms (including Drosophila and mammals). The Spätzle protein outside of cells acts as a ligand for Toll receptors, enabling the transfer of signals from outside the cell to the inside. However, the function of Spätzle in the immune system of mud crab (Scylla paramamosain) remains unclear.

View Article and Find Full Text PDF

E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.

Medicine (Baltimore)

January 2024

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

E2F transcription factors (E2Fs) are a family of transcription factors critical regulators of the cell cycle, apoptosis, and differentiation, thus influencing tumorigenesis. However, the specific roles of E2Fs in lung adenocarcinoma (LUAD) remain unclear. Data from The Cancer Genome Atlas (TCGA) were used.

View Article and Find Full Text PDF

Background: Ferroptosis is a new type of programmed apoptosis and plays an important role in tumour inhibition and immunotherapy.

Objective: In this study, we aimed to explore the potential role of ferroptosis-related genes (FRGs) and the potential therapeutic targets in oral cavity squamous cell carcinoma (OCSCC).

Methods: The transcription data of OCSCC samples were obtained from the Cancer Genome Atlas (TCGA) database as a training dataset.

View Article and Find Full Text PDF

Global crotonylome identifies EP300-regulated ANXA2 crotonylation in cumulus cells as a regulator of oocyte maturation.

Int J Biol Macromol

February 2024

Reproductive Medicine Center, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China; GuangDong Engineering Technology Research Center of Fertility Preservation, Guangzhou 510080, Guangdong, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China. Electronic address:

Lysine crotonylation (Kcr), a newly discovered post-translational modification, played a crucial role in physiology and disease progression. However, the roles of crotonylation in oocyte meiotic resumption remain elusive. As abnormal cumulus cell development will cause oocyte maturation arrest and female infertility, we report that cumulus cells surrounding human meiotic arrested oocytes showed significantly lower crotonylation, which was associated with decreased EP300 expression and blocked cumulus cell expansion.

View Article and Find Full Text PDF

Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional connectivity is not sufficient to reflect the complicated and time-varying properties of the brain. The underlying dynamic interactions between brain functional networks of MDD remain largely unknown, and it is also unclear whether neuroimaging-based dynamic properties are sufficiently robust to discriminate individuals with MDD from healthy controls since the diagnosis of MDD mainly depends on symptom-based criteria evaluated by clinical observation.

View Article and Find Full Text PDF

Background: Adipokines and inflammatory cytokines (ADICs) play important roles in type 2 diabetes mellitus (T2DM). This study aimed to compare the changes of ADIC levels (ΔADICs) in patients with newly diagnosed T2DM treated with different antihyperglycemic agents, and further investigate the impact of these changes on metabolic indices, β-cell function and insulin resistance (IR).

Methods: Four hundred and sixteen patients with newly diagnosed T2DM from 25 centers in China randomly received 48-week intervention with exenatide, insulin or pioglitazone.

View Article and Find Full Text PDF

Sex-Specific Associations of Five Serum Essential Metal Elements with Thyroid Nodules in Euthyroid Adults: a Cross‑sectional Study.

Biol Trace Elem Res

October 2024

Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), No.1 of Jiazi Road, Lunjiao, Shunde District, Foshan City, 528308, Guangdong Province, China.

The association between the serum essential metal elements (magnesium, iron, copper, zinc, and calcium) and thyroid nodules is still inconsistent. The current study aims to investigate the relationship of metal elements with thyroid nodules and their malignant tendency. A total of 6480 Chinese euthyroid adults were included in our study.

View Article and Find Full Text PDF

Lactate inhibits interferon-α response in ovarian cancer by inducing STAT1 ubiquitin degradation.

Int Immunopharmacol

December 2023

Department of Laboratory Medicine of Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. Electronic address:

Article Synopsis
  • Researchers found that lactate, a substance made by cells, affects how the immune system fights ovarian cancer.
  • They discovered that lactate reduces a protein called STAT1, which is important for activating anti-cancer responses.
  • High levels of another protein, Fbxo40, were linked to worse survival in ovarian cancer, meaning targeting lactate might help improve treatments.
View Article and Find Full Text PDF

Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review.

World Neurosurg

April 2024

Division of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals with pediatric-onset TSCI.

Methods: PubMed, Scopus, and Web of Science databases were searched from inception to December 20th, 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and studies were included according to the eligibility criteria.

View Article and Find Full Text PDF

Age affects the association between socioeconomic status and infertility: a cross-sectional study.

BMC Womens Health

December 2023

Department of Gynecology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), No.1 Jiazi Road, Lunjiao, Shunde District, Foshan City, 528308, Guangdong Province, China.

Background: Previous studies have shown the interaction between age and socioeconomic status (SES) on the risk of infertility in the UK, but the association is still unclear in the United States. Therefore, the present study investigated the effect of age on the relationship between SES and the risk of infertility in American women.

Methods: The study included adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018.

View Article and Find Full Text PDF

Background: Rhabdomyolysis (RM)-induced acute kidney injury (AKI) is a common renal disease with low survival rate and inadequate prognosis. In this study, we investigate the feasibility of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) for assessing the progression of RM-induced AKI in a mouse model.

Methods: AKI was induced in C57BL/6J mice via intramuscular injection of 7.

View Article and Find Full Text PDF

Background: Radiomics models could help assess the benign and malignant invasiveness and prognosis of pulmonary nodules. However, the lack of interpretability limits application of these models. We thus aimed to construct and validate an interpretable and generalized computed tomography (CT) radiomics model to evaluate the pathological invasiveness in patients with a solitary pulmonary nodule in order to improve the management of these patients.

View Article and Find Full Text PDF

Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy.

Biochim Biophys Acta Mol Basis Dis

February 2024

Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong 528308, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China; The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address:

Objectives: Secreted frizzled-related protein 2 (SFRP2), a novel adipokine that used to be considered an inhibitor of the canonical Wnt pathway, may play a protective role in metabolic disorders. However, its effect on diabetic cardiomyopathy was still unclear. Accumulating evidence indicates that mitophagy can protect cardiac function in the diabetic heart.

View Article and Find Full Text PDF

Immune checkpoint inhibitors (ICIs) show promise as second-line treatment for advanced bladder cancer (BLCA); however, their responsiveness is limited by the immune evasion mechanisms in tumor cells. This study conduct a Cox regression analysis to screen mRNA-binding proteins and reveals an association between Ras GTPase-activating protein-binding protein 1 (G3BP1) and diminished effectiveness of ICI therapy in patients with advanced BLCA. Subsequent investigation demonstrates that G3BP1 enhances immune evasion in BLCA cells by downregulating major histocompatibility complex class I (MHC-I) through phosphoinositide 3-kinase (PI3K)/Akt signaling activation.

View Article and Find Full Text PDF
Article Synopsis
  • Endometrial receptivity is crucial for successful embryo implantation, especially in women undergoing assisted reproductive technology.
  • Recent studies suggest that intrauterine infusion of platelet-rich plasma (PRP) can enhance endometrial thickness and receptivity, leading to better reproductive outcomes.
  • This review focuses on the mechanisms by which PRP may improve endometrial receptivity and discusses existing research on the effects of PRP therapy.
View Article and Find Full Text PDF

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age.

Front Endocrinol (Lausanne)

December 2023

Department of Andrology, National Health Commission (NHC) Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, China.

Background: Klinefelter's syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this. The key to predict and promote spermatogenesis is to find targets that regulate focal spermatogenesis.

Objective: To explore the trend of fertility changes in KS patients at different ages and identify potential therapeutic targets.

View Article and Find Full Text PDF

Background: is a transmembrane protein involved in biological signaling and plays an important role in the stability and transcription of P53. However, its role in tumor remains unknown.

Methods: Using R language, the expression level of 33 cancer spectrum was analyzed by the public database TCGA, GEO and HPA, the differential expressed gene (DEG) screening and protein interaction (PPI) network was constructed, and the differential genes of in colon cancer were identified.

View Article and Find Full Text PDF

Background: The T2* value of interventricular septum is routinely reported for grading myocardial iron load in thalassemia major, and automatic segmentation of septum could shorten analysis time and reduce interobserver variability.

Purpose: To develop a deep learning-based method for automatic septum segmentation from black-blood MR images for the myocardial T2* measurement of thalassemia patients.

Study Type: Retrospective.

View Article and Find Full Text PDF

Objectives: The aim of this study is to establish a self-simple-to-use nomogram to predict the risk of multimorbidity among middle-aged and older adults.

Design: A retrospective cohort study.

Participants: We used data from the Chinese Longitudinal Healthy Longevity Survey, including 7735 samples.

View Article and Find Full Text PDF

Background: Perineural invasion (PNI) of intrahepatic cholangiocarcinoma (ICC) is a strong independent risk factor for tumour recurrence and long-term patient survival. However, there is a lack of noninvasive tools for accurately predicting the PNI status. The authors develop and validate a combined model incorporating radiomics signature and clinicoradiological features based on machine learning for predicting PNI in ICC, and used the Shapley Additive explanation (SHAP) to visualize the prediction process for clinical application.

View Article and Find Full Text PDF

Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD by regulating the phenotype of microglia. Recent studies suggest that TREM2 regulates high glucose-induced microglial inflammation through the NLRP3 signaling pathway.

View Article and Find Full Text PDF

Aim: This study aimed to investigate the effects of intensive psychological intervention care on adverse emotions and post-traumatic stress disorder (PTSD) symptoms in female teenage patients after induced abortion.

Methods: This prospective cohort study included 100 teenage female patients seeking induced abortion who were randomly divided into two groups: the intervention group ( = 50) and the control group ( = 50). The intervention group received intensive psychological intervention care, while the control group received standard routine nursing.

View Article and Find Full Text PDF