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Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals.

Cell Mol Gastroenterol Hepatol

October 2022

Biomedical Research Center, Southern Medical University, Guangzhou, China; Department of Hepatology, Southern Medical University Affiliated Shenzhen Hospital, Shenzhen, China. Electronic address:

Background & Aims: Glia maturation factor-β (GMFB) is a bona fide member of the actin depolymerizing factor homology family. Recently, emerging evidence suggested its implication in liver diseases, but data on its role in liver remain limited.

Methods: Assessment of GMFB in liver histology, impact on liver regeneration and hepatocyte proliferation, and the underlying molecular pathways were conducted using mouse models with acute liver injury.

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