6 results match your criteria: "Southern Medical University (the First Military Medical University)[Affiliation]"
[The development and application of an encapsulated aneurysm clip with biomembrane graft across the vessels].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
June 2008
Department of Neurosurgery, Nanfang Hospital, Southern Medical University (The First Military Medical University), Guangzhou 510515, China.
The external wrapping of intracranial aneurysm is the definitive treatment of choice for surgical clipping or endovascular occlusion, yet there may exist considerable difficulties and risks because so far neither ideal wrapping techniques nor ideal wrapping materials have been obtained. An encapsulated aneurysm clip with biomembrane graft across the vessels is introduced in this article. By clipping the neck and wrapping the sack of aneurysm simultaneously, this clip successfully solves the problems of unreasonable encapsulated materials and techniques; it has been proved to be an effective method for treating intracranial refractory aneurysms.
View Article and Find Full Text PDFAnalysis of the CDR3 length of TCR alphabeta T cells in the peripheral blood of patients with chronic hepatitis B.
Hepatol Res
May 2006
Institute of Molecular Immunology, Southern Medical University (The First Military Medical University), GuangZhou 510515, PR China.
To clarify the characteristics of TCR alphabeta T cells in the peripheral blood of patients with chronic hepatitis B (CHB), we investigated the patterns of Complementarity Determining Region3 (CDR3) length distribution for all 24 TCR BV gene families and 32 TCR AV gene family in the peripheral blood lymphocytes of two patients with CHB and two healthy controls by immunoscope spectratyping technique. We found that the profiles of CDR3 length distribution for all TCR AV and TCR BV family showed Gaussian distribution (the polyclonal TCR alphabeta T cells) in healthy controls, however, the restricted usage of TCR BV and TCR AV family (the oligoclonal TCR alphabeta T cells) has been monitored in two CHB patients, furthermore, the oligoclonal TCR alphabeta T cells showed the different CDR3 sequences and length, it might be correlated to the different epitope of hepatitis B virus (HBV) or the different HLA type of the patients. Detailed analysis of the CDR3 length of TCR alphabeta T cells might be interesting to light on the further study of the individualized immunotherapy of CHB and the further research of the new T lymphocyte epitope vaccine of HBV.
View Article and Find Full Text PDF[Study of antithrombotic function of endothelium in vascular tissue engineering].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2005
Department of Clinical Laboratory, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, P R China.
Article Synopsis
- The study explores the current trends in understanding how the endothelium contributes to the antithrombotic function within vascular tissue engineering.
- Various factors influencing this function were analyzed, including the source of endothelial cells, matrix material properties, cell culture techniques, and gene modifications.
- The findings emphasize that optimizing antithrombotic capabilities in engineered tissues necessitates more research on cell sources, materials, culture methods, and particularly gene modification strategies.
[Experimental gene therapy of keloid in vitro using recombinant adenovirus coding for Fas gene].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2005
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, P R China.
Article Synopsis
- The research aimed to replace the dysfunctional Fas gene with recombinant Adenovirus containing the human Fas gene to improve keloid treatment.
- The study involved infecting fibroblasts from keloids with Adenovirus and comparing Fas protein expression levels before and after infection, revealing increased Fas expression and apoptosis.
- The findings suggest that the recombinant Adenovirus effectively enhances Fas protein expression in keloid fibroblasts and may lead to promising gene therapy approaches for keloid treatment.
[p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2005
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, PR China.
Objective: To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.
Methods: The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.
Results: The frequency of the Pro allele (P = 0.
[The research of assembling animal models of keloid employing the method of tissue engineering].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2005
Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, P R China.
Objective: To build animal models of keloid by method of tissue engineering and to discuss the feasibility of using it in clinical and lab researches.
Methods: Fibroblasts(FB) were isolated from keloids and cultured. The seventh and eighth generation of the cultured FBs were inoculated into the copolymers of polylactic acid and polyglycolic PLGA.